Association Between Abdominal Body Composition, Inflammation, and Risk for Cardiovascular Disease (The MESA ABD Study)

NCT00612365 | Completed

• 2 other identifiers: 1419R01HL088451
• Study Type: observational
• Target: 1,975
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity is a growing public health concern, with approximately 31% of Americans considered obese. The link between abdominal obesity and cardiovascular disease (CVD) has been well established, but the effect of distinct types of abdominal fat tissue on CVD risk is not well known. The rate of obesity and the distribution of abdominal fat differ with age, sex, and ethnicity. These differences may have important implications for determining ethnic-specific relationships between abdominal body composition (ABC), inflammation, and CVD events. This study will evaluate the association between measures of abdominal fat, CVD risk, and inflammation in terms of ethnicity-, sex-, and age-specific differences.

Conditions

Cardiovascular Diseases; Obesity

Keywords

Body Composition; Abdomen; Atherosclerosis

Outcome Measures

Primary Outcomes (1)

• Relationship between abdominal tissue types, levels of inflammatory markers and adipokines, and CVD events

  Measured at completion of sample analysis

Secondary Outcomes (1)

• How differences in age, sex, and ethnicity influence the association between ABC and CVD risk

  Measured at completion of sample analysis

Study Arms (1)

1

Participants from the Multi-Ethnic Study of Atherosclerosis (MESA) for abdominal aortic calcium (AAC) who have undergone computed tomography (CT) scans of the abdomen

Eligibility Criteria

• Age: 45 Years - 84 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study will use data and specimens from participants in the MESA study for AAC who have undergone CT scans of the abdomen.

You may qualify if:

• Participant in the MESA study

You may not qualify if:

• History of cardiovascualar disease

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Study Sites (1)

University of California San Diego

La Jolla, California, 92093, United States

Location

MeSH Terms

Conditions

Cardiovascular Diseases; Obesity; Atherosclerosis

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• Matthew A. Allison, MD, MPH

  University of California, San Diego

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: NIH

Study Record Dates

• First Submitted: February 7, 2008
• First Posted: February 11, 2008
• Study Start: September 1, 2007
• Primary Completion: August 1, 2012
• Study Completion: June 1, 2013
• Last Updated: July 29, 2016

Record last verified: 2009-02

Locations

US (1)