Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)
COPDGene
Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene)
4 other identifiers
observational
10,718
1 country
20
Brief Summary
Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that is often caused by cigarette smoking. The purpose of this study is to evaluate whether certain genetic factors predispose some smokers to develop COPD more than others.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2007
Longer than P75 for all trials
20 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2007
CompletedFirst Submitted
Initial submission to the registry
January 28, 2008
CompletedFirst Posted
Study publicly available on registry
February 6, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
August 1, 2028
September 17, 2025
September 1, 2025
20.8 years
January 28, 2008
September 16, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Forced expiratory volume in 1 second (FEV1)
Measured at baseline
Emphysema, as shown on chest CT scan
Measured at baseline
Airway wall thickness on chest CT scan
Measured at baseline
COPD status (COPD participants versus control group participants)
Measured at baseline
Study Arms (4)
NHW COPD Participants
Non-Hispanic white participants with COPD
NHW Control Group
Non-Hispanic white participants with normal spirometry (do not have COPD)
AA COPD Participants
African-American participants with COPD
AA Control Group
African-American participants with normal spirometry (do not have COPD)
Eligibility Criteria
Particpants with COPD will include outpatient clinic patients, patients in registries, previous study participants, and COPD Foundation volunteers. Participants without COPD will include spouses and friends of study participants with COPD and patients at primary care practices.
You may qualify if:
- At least 10 pack-years of cigarette smoking (although a of nonsmoking controls is also being enrolled)
- Self-designation of non-Hispanic white or African-American
You may not qualify if:
- Other lung diseases (except for asthma in participants with COPD)
- Pregnant
- Cancer (other than skin cancer) in the 5 years prior to study entry
- Received antibiotics for a COPD exacerbation in the 1 month prior to study entry
- First- or second-degree relative of a previously enrolled study participant
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (20)
University of Alabama at Birmingham
Birmingham, Alabama, 35249, United States
University of California at San Diego
San Diego, California, 92103, United States
Los Angeles Biomedical Research Institute
Torrance, California, 90502, United States
National Jewish Health
Denver, Colorado, 80206, United States
Morehouse School of Medicine
Atlanta, Georgia, 30310, United States
University of Iowa
Iowa City, Iowa, 52242, United States
Johns Hopkins University
Baltimore, Maryland, 21224, United States
Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
Reliant Medical Group
Worcester, Massachusetts, 01608, United States
Ann Arbor VA Medical Center
Ann Arbor, Michigan, 48105, United States
University of Michigan
Ann Arbor, Michigan, 48109, United States
Minneapolis VA Medical Center
Minneapolis, Minnesota, 55417, United States
HealthPartners Research Foundation
Minneapolis, Minnesota, 55440, United States
University of Minnesota
Minneapolis, Minnesota, 55455, United States
Columbia University Medical Center
New York, New York, 10032, United States
Duke University
Durham, North Carolina, 27710, United States
Temple University
Philadelphia, Pennsylvania, 19140, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, 15232, United States
Baylor College of Medicine
Houston, Texas, 77030, United States
University of Texas Health Sciences Center at San Antonio
San Antonio, Texas, 78229, United States
Related Publications (119)
Zhang C, Konigsberg IR, He Y, Zhang J, Chikowore T, Feldman WB, Hu X, Ding Y, Pasaniuc B, Chang D, Chen Q, Lasky-Su JA, Hecker J, Tobin MD, Chen J, Kalra S, Pratte KA, Im HK, Wan ES, Manichaikul A, Silverman EK, Bowler RP, Lange LA, Ortega VE, Martin AR, Cho MH, Moll MR. Multi-Trait Polygenic Scores for COPD and COPD Exacerbations Implicate Druggable Proteins. medRxiv [Preprint]. 2025 Aug 26:2025.08.22.25334001. doi: 10.1101/2025.08.22.25334001.
PMID: 40909810DERIVEDAwan HA, Chaudhary MFA, El-Sokkary AD, Hoffman EA, Comellas AP, Guo J, Barjaktarevic IZ, Barr RG, Bhatt SP, Bodduluri S, Bowler RP, Vargas Buonfiglio LG, Cooper CB, Fawzy A, Hastie AT, Labaki WW, Martinez FJ, Menchaca MG, O'Neal W, Paine R 3rd, Schroeder JD, Woodruff PG, Curtis JL, Reinhardt JM. Association of Lung Quantitative CT Scan Textures With Systemic Inflammation and Mortality in COPD. Chest. 2025 Nov;168(5):1107-1119. doi: 10.1016/j.chest.2025.04.017. Epub 2025 Apr 22.
PMID: 40268239DERIVEDKalra S, Hobbs B, Hunninghake GM, Menon AA, Putman R, Cutting C, Hatabu H, Silverman EK, Wan E, Cho MH, Moll M. The Association of Interstitial Lung Abnormalities and Preserved Ratio Impaired Spirometry With Mortality. Chest. 2025 Jul;168(1):136-145. doi: 10.1016/j.chest.2025.02.002. Epub 2025 Feb 11.
PMID: 39947315DERIVEDLee AN, Hsiao A, Hasenstab KA. Evaluating the Cumulative Benefit of Inspiratory CT, Expiratory CT, and Clinical Data for COPD Diagnosis and Staging through Deep Learning. Radiol Cardiothorac Imaging. 2024 Dec;6(6):e240005. doi: 10.1148/ryct.240005.
PMID: 39665633DERIVEDvan der Veer T, Andrinopoulou ER, Braunstahl GJ, Charbonnier JP, Kim V, Latisenko R, Lynch DA, Tiddens H. Association between automatic AI-based quantification of airway-occlusive mucus plugs and all-cause mortality in patients with COPD. Thorax. 2025 Jan 17;80(2):105-108. doi: 10.1136/thorax-2024-221928.
PMID: 39638548DERIVEDShirahata T, Enzer NA, Castro V, Chiles J, McDonald ML, Choi B, Diaz AA, Washko GR, San Jose Estepar R, Ash SY, Rahaghi FN. Effect of Common Medications on Longitudinal Pectoralis Muscle Area in Smokers. Chronic Obstr Pulm Dis. 2025 Jan 29;12(1):23-32. doi: 10.15326/jcopdf.2024.0557.
PMID: 39636057DERIVEDBell AJ, Ram S, Labaki WW, Murray S, Kazerooni EA, Galban S, Martinez FJ, Hatt CR, Wang JM, Ivanov V, McGettigan P, Khokhlovich E, Maiorino E, Suryadevara R, Boueiz A, Castaldi PJ, Mirkes EM, Zinovyev A, Gorban AN, Galban CJ, Han MK. Temporal Exploration of Chronic Obstructive Pulmonary Disease Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts. Am J Respir Crit Care Med. 2025 Apr;211(4):569-576. doi: 10.1164/rccm.202401-0127OC.
PMID: 39269427DERIVEDYang HM, Ryu MH, Carey VJ, Young K, Kinney GL, Dransfield MT, Wade RC, Wells JM, Budoff MJ, Castaldi PJ, Hersh CP, Silverman EK. Differential Association of COPD Subtypes With Cardiovascular Events and COPD Exacerbations. Chest. 2024 Dec;166(6):1360-1370. doi: 10.1016/j.chest.2024.07.148. Epub 2024 Jul 31.
PMID: 39094733DERIVEDYang HM, Ryu MH, Carey VJ, Kinney GL, Hokanson JE, Dransfield MT, Hersh CP, Silverman EK; COPDGene Investigators dagger. Chronic Obstructive Pulmonary Disease Exacerbations Increase the Risk of Subsequent Cardiovascular Events: A Longitudinal Analysis of the COPDGene Study. J Am Heart Assoc. 2024 Jun 4;13(11):e033882. doi: 10.1161/JAHA.123.033882. Epub 2024 May 31.
PMID: 38818936DERIVEDNadeem SA, Comellas AP, Regan EA, Hoffman EA, Saha PK. Chest CT-based automated vertebral fracture assessment using artificial intelligence and morphologic features. Med Phys. 2024 Jun;51(6):4201-4218. doi: 10.1002/mp.17072. Epub 2024 May 9.
PMID: 38721977DERIVEDWang JM, Bell AJ, Ram S, Labaki WW, Hoff BA, Murray S, Kazerooni EA, Galban S, Hatt CR, Han MK, Galban CJ. Topologic Parametric Response Mapping Identifies Tissue Subtypes Associated with Emphysema Progression. Acad Radiol. 2024 Mar;31(3):1148-1159. doi: 10.1016/j.acra.2023.08.003. Epub 2023 Sep 2.
PMID: 37661554DERIVEDXie W, Jacobs C, Charbonnier JP, Slebos DJ, van Ginneken B. Emphysema subtyping on thoracic computed tomography scans using deep neural networks. Sci Rep. 2023 Aug 29;13(1):14147. doi: 10.1038/s41598-023-40116-6.
PMID: 37644032DERIVEDVestal BE, Ghosh D, Estepar RSJ, Kechris K, Fingerlin T, Carlson NE. Quantifying the spatial clustering characteristics of radiographic emphysema explains variability in pulmonary function. Sci Rep. 2023 Aug 24;13(1):13862. doi: 10.1038/s41598-023-40950-8.
PMID: 37620507DERIVEDAmudala Puchakayala PR, Sthanam VL, Nakhmani A, Chaudhary MFA, Kizhakke Puliyakote A, Reinhardt JM, Zhang C, Bhatt SP, Bodduluri S. Radiomics for Improved Detection of Chronic Obstructive Pulmonary Disease in Low-Dose and Standard-Dose Chest CT Scans. Radiology. 2023 Jun;307(5):e222998. doi: 10.1148/radiol.222998.
PMID: 37338355DERIVEDHayden LP, Hobbs BD, Busch R, Cho MH, Liu M, Lopes-Ramos CM, Lomas DA, Bakke P, Gulsvik A, Silverman EK, Crapo JD, Beaty TH, Laird NM, Lange C, DeMeo DL. X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study. Respir Res. 2023 Feb 1;24(1):38. doi: 10.1186/s12931-023-02337-1.
PMID: 36726148DERIVEDGregory A, Xu Z, Pratte K, Lee S, Liu C, Chase R, Yun J, Saferali A, Hersh CP, Bowler R, Silverman E, Castaldi PJ, Boueiz A. Clustering-based COPD subtypes have distinct longitudinal outcomes and multi-omics biomarkers. BMJ Open Respir Res. 2022 Aug;9(1):e001182. doi: 10.1136/bmjresp-2021-001182.
PMID: 35999035DERIVEDBalasubramanian A, Putcha N, MacIntyre NR, Jensen RL, Kinney G, Stringer WW, Hersh CP, Bowler RP, Casaburi R, Han MK, Porszasz J, Barr RG, Regan E, Make BJ, Hansel NN, Wise RA, McCormack MC. Diffusing Capacity and Mortality in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2023 Jan;20(1):38-46. doi: 10.1513/AnnalsATS.202203-226OC.
PMID: 35969416DERIVEDOh AS, Baraghoshi D, Lynch DA, Ash SY, Crapo JD, Humphries SM; COPDGene Investigators. Emphysema Progression at CT by Deep Learning Predicts Functional Impairment and Mortality: Results from the COPDGene Study. Radiology. 2022 Sep;304(3):672-679. doi: 10.1148/radiol.213054. Epub 2022 May 17.
PMID: 35579519DERIVEDWan ES, Hokanson JE, Regan EA, Young KA, Make BJ, DeMeo DL, Mason SE, San Jose Estepar R, Crapo JD, Silverman EK. Significant Spirometric Transitions and Preserved Ratio Impaired Spirometry Among Ever Smokers. Chest. 2022 Mar;161(3):651-661. doi: 10.1016/j.chest.2021.09.021. Epub 2021 Sep 27.
PMID: 34592319DERIVEDYun JH, Lee C, Liu T, Liu S, Kim EY, Xu S, Curtis JL, Pinello L, Bowler RP, Silverman EK, Hersh CP, Zhou X. Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice. JCI Insight. 2021 Sep 8;6(17):e144575. doi: 10.1172/jci.insight.144575.
PMID: 34375314DERIVEDMaselli DJ, Yen A, Wang W, Okajima Y, Dolliver WR, Mercugliano C, Anzueto A, Restrepo MI, Aksamit TR, Basavaraj A, Aliberti S, Young KA, Kinney GL, Wells JM, San Jose Estepar R, Lynch DA, Diaz AA. Small Airway Disease and Emphysema Are Associated with Future Exacerbations in Smokers with CT-derived Bronchiectasis and COPD: Results from the COPDGene Cohort. Radiology. 2021 Sep;300(3):706-714. doi: 10.1148/radiol.2021204052. Epub 2021 Jun 22.
PMID: 34156303DERIVEDTejwani V, Fawzy A, Putcha N, Castaldi PJ, Cho MH, Pratte KA, Bhatt SP, Lynch DA, Humphries SM, Kinney GL, D'Alessio FR, Hansel NN; COPDGene Investigators. Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort. Chest. 2021 Oct;160(4):1245-1254. doi: 10.1016/j.chest.2021.05.007. Epub 2021 May 21.
PMID: 34029566DERIVEDLuehrs RE, Moreau KL, Pierce GL, Wamboldt F, Aloia M, Weinberger HD, Make B, Bowler R, Crapo JD, Meschede K, Kozora E, Moser DJ, Hoth KF. Cognitive performance is lower among individuals with overlap syndrome than in individuals with COPD or obstructive sleep apnea alone: association with carotid artery stiffness. J Appl Physiol (1985). 2021 Jul 1;131(1):131-141. doi: 10.1152/japplphysiol.00477.2020. Epub 2021 May 13.
PMID: 33982592DERIVEDAmaza IP, O'Shea AMJ, Fortis S, Comellas AP. Discordant Quantitative and Visual CT Assessments in the Diagnosis of Emphysema. Int J Chron Obstruct Pulmon Dis. 2021 May 3;16:1231-1242. doi: 10.2147/COPD.S284477. eCollection 2021.
PMID: 33976544DERIVEDWu TD, Fawzy A, Kinney GL, Bon J, Neupane M, Tejwani V, Hansel NN, Wise RA, Putcha N, McCormack MC. Metformin use and respiratory outcomes in asthma-COPD overlap. Respir Res. 2021 Feb 26;22(1):70. doi: 10.1186/s12931-021-01658-3.
PMID: 33637087DERIVEDPistenmaa CL, Nardelli P, Ash SY, Come CE, Diaz AA, Rahaghi FN, Barr RG, Young KA, Kinney GL, Simmons JP, Wade RC, Wells JM, Hokanson JE, Washko GR, San Jose Estepar R; COPDGene Investigators. Pulmonary Arterial Pruning and Longitudinal Change in Percent Emphysema and Lung Function: The Genetic Epidemiology of COPD Study. Chest. 2021 Aug;160(2):470-480. doi: 10.1016/j.chest.2021.01.084. Epub 2021 Feb 16.
PMID: 33607083DERIVEDAsh SY, San Jose Estepar R, Fain SB, Tal-Singer R, Stockley RA, Nordenmark LH, Rennard S, Han MK, Merrill D, Humphries SM, Diaz AA, Mason SE, Rahaghi FN, Pistenmaa CL, Sciurba FC, Vegas-Sanchez-Ferrero G, Lynch DA, Washko GR; COPDGene Investigators and the COPD Biomarker Qualification Consortium. Relationship between Emphysema Progression at CT and Mortality in Ever-Smokers: Results from the COPDGene and ECLIPSE Cohorts. Radiology. 2021 Apr;299(1):222-231. doi: 10.1148/radiol.2021203531. Epub 2021 Feb 16.
PMID: 33591891DERIVEDMoll M, Lutz SM, Ghosh AJ, Sakornsakolpat P, Hersh CP, Beaty TH, Dudbridge F, Tobin MD, Mittleman MA, Silverman EK, Hobbs BD, Cho MH. Relative contributions of family history and a polygenic risk score on COPD and related outcomes: COPDGene and ECLIPSE studies. BMJ Open Respir Res. 2020 Nov;7(1):e000755. doi: 10.1136/bmjresp-2020-000755.
PMID: 33239407DERIVEDBillatos E, Ash SY, Duan F, Xu K, Romanoff J, Marques H, Moses E, Han MK, Regan EA, Bowler RP, Mason SE, Doyle TJ, San Jose Estepar R, Rosas IO, Ross JC, Xiao X, Liu H, Liu G, Sukumar G, Wilkerson M, Dalgard C, Stevenson C, Whitney D, Aberle D, Spira A, San Jose Estepar R, Lenburg ME, Washko GR; DECAMP and COPDGene Investigators. Distinguishing Smoking-Related Lung Disease Phenotypes Via Imaging and Molecular Features. Chest. 2021 Feb;159(2):549-563. doi: 10.1016/j.chest.2020.08.2115. Epub 2020 Sep 16.
PMID: 32946850DERIVEDBaldomero AK, Wendt CH, Petersen A, Gaeckle NT, Han MK, Kunisaki KM; COPDGene Investigators. Impact of gastroesophageal reflux on longitudinal lung function and quantitative computed tomography in the COPDGene cohort. Respir Res. 2020 Aug 3;21(1):203. doi: 10.1186/s12931-020-01469-y.
PMID: 32746820DERIVEDBodduluri S, Nakhmani A, Reinhardt JM, Wilson CG, McDonald ML, Rudraraju R, Jaeger BC, Bhakta NR, Castaldi PJ, Sciurba FC, Zhang C, Bangalore PV, Bhatt SP. Deep neural network analyses of spirometry for structural phenotyping of chronic obstructive pulmonary disease. JCI Insight. 2020 Jul 9;5(13):e132781. doi: 10.1172/jci.insight.132781.
PMID: 32554922DERIVEDWashko GR, Nardelli P, Ash SY, Rahaghi FN, Vegas Sanchez-Ferrero G, Come CE, Dransfield MT, Kalhan R, Han MK, Bhatt SP, Wells JM, Pistenmaa CL, Diaz AA, Ross JC, Rennard S, Querejeta Roca G, Shah AM, Young K, Kinney GL, Hokanson JE, Agusti A, San Jose Estepar R; COPDGene Investigators. Smaller Left Ventricle Size at Noncontrast CT Is Associated with Lower Mortality in COPDGene Participants. Radiology. 2020 Jul;296(1):208-215. doi: 10.1148/radiol.2020191793. Epub 2020 May 5.
PMID: 32368963DERIVEDHoth KF, Moreau KL, Weinberger HD, Holm KE, Meschede K, Crapo JD, Make BJ, Moser DJ, Kozora E, Bowler RP, Pierce GL, Ten Eyck P, Wamboldt FS. Carotid Artery Stiffness is Associated With Cognitive Performance in Former Smokers With and Without Chronic Obstructive Pulmonary Disease. J Am Heart Assoc. 2020 May 5;9(9):e014862. doi: 10.1161/JAHA.119.014862. Epub 2020 Apr 26.
PMID: 32338117DERIVEDLowe KE, Regan EA, Anzueto A, Austin E, Austin JHM, Beaty TH, Benos PV, Benway CJ, Bhatt SP, Bleecker ER, Bodduluri S, Bon J, Boriek AM, Boueiz AR, Bowler RP, Budoff M, Casaburi R, Castaldi PJ, Charbonnier JP, Cho MH, Comellas A, Conrad D, Costa Davis C, Criner GJ, Curran-Everett D, Curtis JL, DeMeo DL, Diaz AA, Dransfield MT, Dy JG, Fawzy A, Fleming M, Flenaugh EL, Foreman MG, Fortis S, Gebrekristos H, Grant S, Grenier PA, Gu T, Gupta A, Han MK, Hanania NA, Hansel NN, Hayden LP, Hersh CP, Hobbs BD, Hoffman EA, Hogg JC, Hokanson JE, Hoth KF, Hsiao A, Humphries S, Jacobs K, Jacobson FL, Kazerooni EA, Kim V, Kim WJ, Kinney GL, Koegler H, Lutz SM, Lynch DA, MacIntye NR Jr, Make BJ, Marchetti N, Martinez FJ, Maselli DJ, Mathews AM, McCormack MC, McDonald MN, McEvoy CE, Moll M, Molye SS, Murray S, Nath H, Newell JD Jr, Occhipinti M, Paoletti M, Parekh T, Pistolesi M, Pratte KA, Putcha N, Ragland M, Reinhardt JM, Rennard SI, Rosiello RA, Ross JC, Rossiter HB, Ruczinski I, San Jose Estepar R, Sciurba FC, Sieren JC, Singh H, Soler X, Steiner RM, Strand MJ, Stringer WW, Tal-Singer R, Thomashow B, Vegas Sanchez-Ferrero G, Walsh JW, Wan ES, Washko GR, Michael Wells J, Wendt CH, Westney G, Wilson A, Wise RA, Yen A, Young K, Yun J, Silverman EK, Crapo JD. COPDGene(R) 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2019 Nov;6(5):384-399. doi: 10.15326/jcopdf.6.5.2019.0149.
PMID: 31710793DERIVEDBalasubramanian A, MacIntyre NR, Henderson RJ, Jensen RL, Kinney G, Stringer WW, Hersh CP, Bowler RP, Casaburi R, Han MK, Porszasz J, Barr RG, Make BJ, Wise RA, McCormack MC. Diffusing Capacity of Carbon Monoxide in Assessment of COPD. Chest. 2019 Dec;156(6):1111-1119. doi: 10.1016/j.chest.2019.06.035. Epub 2019 Jul 25.
PMID: 31352035DERIVEDKim W, Cho MH, Sakornsakolpat P, Lynch DA, Coxson HO, Tal-Singer R, Silverman EK, Beaty TH. DSP variants may be associated with longitudinal change in quantitative emphysema. Respir Res. 2019 Jul 19;20(1):160. doi: 10.1186/s12931-019-1097-8.
PMID: 31324189DERIVEDPark J, Hobbs BD, Crapo JD, Make BJ, Regan EA, Humphries S, Carey VJ, Lynch DA, Silverman EK; COPDGene Investigators. Subtyping COPD by Using Visual and Quantitative CT Imaging Features. Chest. 2020 Jan;157(1):47-60. doi: 10.1016/j.chest.2019.06.015. Epub 2019 Jul 5.
PMID: 31283919DERIVEDde la Hoz RE, Liu X, Celedon JC, Doucette JT, Jeon Y, Reeves AP, San Jose Estepar R. Association of Obesity with Quantitative Chest CT Measured Airway Wall Thickness in WTC Workers with Lower Airway Disease. Lung. 2019 Aug;197(4):517-522. doi: 10.1007/s00408-019-00246-z. Epub 2019 Jun 28.
PMID: 31254057DERIVEDHarmouche R, Ash SY, Putman RK, Hunninghake GM, San Jose Estepar R, Martinez FJ, Choi AM, Lynch DA, Hatabu H, Han MK, Bowler RP, Kalhan R, Rosas IO, Washko GR, San Jose Estepar R; COPDGene Investigators. Objectively Measured Chronic Lung Injury on Chest CT. Chest. 2019 Dec;156(6):1149-1159. doi: 10.1016/j.chest.2019.05.020. Epub 2019 Jun 22.
PMID: 31233744DERIVEDMaselli DJ, Bhatt SP, Anzueto A, Bowler RP, DeMeo DL, Diaz AA, Dransfield MT, Fawzy A, Foreman MG, Hanania NA, Hersh CP, Kim V, Kinney GL, Putcha N, Wan ES, Wells JM, Westney GE, Young KA, Silverman EK, Han MK, Make BJ. Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study. Chest. 2019 Aug;156(2):228-238. doi: 10.1016/j.chest.2019.04.135. Epub 2019 May 30.
PMID: 31154041DERIVEDKim V, Zhao H, Regan E, Han MK, Make BJ, Crapo JD, Jones PW, Curtis JL, Silverman EK, Criner GJ; COPDGene Investigators. The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition. Chest. 2019 Oct;156(4):685-695. doi: 10.1016/j.chest.2019.03.041. Epub 2019 May 15.
PMID: 31047955DERIVEDOudkerk SF, Mohamed Hoesein FAA, Oner FC, Verlaan JJ, de Jong PA, Kuperus JS, Cho M, McDonald ML, Lynch DA, Silverman EK, Crapo JD, Make BJ, Lowe KE, Regan EA. Diffuse Idiopathic Skeletal Hyperostosis in Smokers and Restrictive Spirometry Pattern: An Analysis of the COPDGene Cohort. J Rheumatol. 2020 Apr;47(4):531-538. doi: 10.3899/jrheum.181357. Epub 2019 May 1.
PMID: 31043539DERIVEDKuperus JS, Oudkerk SF, Foppen W, Mohamed Hoesein FA, Gielis WP, Waalwijk J, Regan EA, Lynch DA, Oner FC, de Jong PA, Verlaan JJ. Criteria for Early-Phase Diffuse Idiopathic Skeletal Hyperostosis: Development and Validation. Radiology. 2019 May;291(2):420-426. doi: 10.1148/radiol.2019181695. Epub 2019 Apr 2.
PMID: 30938626DERIVEDFortis S, Comellas A, Make BJ, Hersh CP, Bodduluri S, Georgopoulos D, Kim V, Criner GJ, Dransfield MT, Bhatt SP; COPDGene Investigators-Core Units: <italic>Administrative Center</italic>, COPDGene Investigators-Clinical Centers: <italic>Ann Arbor VA</italic>. Combined Forced Expiratory Volume in 1 Second and Forced Vital Capacity Bronchodilator Response, Exacerbations, and Mortality in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2019 Jul;16(7):826-835. doi: 10.1513/AnnalsATS.201809-601OC.
PMID: 30908927DERIVEDBhatt SP, Bodduluri S, Raghav V, Bhakta NR, Wilson CG, Kim YI, Eberlein M, Sciurba FC, Han MK, Dransfield MT, Nakhmani A. The Peak Index: Spirometry Metric for Airflow Obstruction Severity and Heterogeneity. Ann Am Thorac Soc. 2019 Aug;16(8):982-989. doi: 10.1513/AnnalsATS.201811-812OC.
PMID: 30865842DERIVEDWan ES, Silverman EK. Reply to Marruchella: Preserved Ratio Impaired Spirometry and Interstitial Lung Abnormalities in Smokers. Am J Respir Crit Care Med. 2019 May 15;199(10):1293-1294. doi: 10.1164/rccm.201901-0018LE. No abstract available.
PMID: 30802417DERIVEDWashko GR, Nardelli P, Ash SY, Vegas Sanchez-Ferrero G, Rahaghi FN, Come CE, Dransfield MT, Kalhan R, Han MK, Bhatt SP, Wells JM, Aaron CP, Diaz AA, Ross JC, Cuttica MJ, Labaki WW, Querejeta Roca G, Shah AM, Young K, Kinney GL, Hokanson JE, Agusti A, San Jose Estepar R. Arterial Vascular Pruning, Right Ventricular Size, and Clinical Outcomes in Chronic Obstructive Pulmonary Disease. A Longitudinal Observational Study. Am J Respir Crit Care Med. 2019 Aug 15;200(4):454-461. doi: 10.1164/rccm.201811-2063OC.
PMID: 30758975DERIVEDSakornsakolpat P, McCormack M, Bakke P, Gulsvik A, Make BJ, Crapo JD, Cho MH, Silverman EK. Genome-Wide Association Analysis of Single-Breath DlCO. Am J Respir Cell Mol Biol. 2019 May;60(5):523-531. doi: 10.1165/rcmb.2018-0384OC.
PMID: 30694715DERIVEDShaddox E, Peterson CB, Stingo FC, Hanania NA, Cruickshank-Quinn C, Kechris K, Bowler R, Vannucci M. Bayesian inference of networks across multiple sample groups and data types. Biostatistics. 2020 Jul 1;21(3):561-576. doi: 10.1093/biostatistics/kxy078.
PMID: 30590505DERIVEDMiller ER, Putman RK, Diaz AA, Xu H, San Jose Estepar R, Araki T, Nishino M, Poli de Frias S, Hida T, Ross J, Coxson H, Dupuis J, O'Connor GT, Silverman EK, Rosas IO, Hatabu H, Washko G, Hunninghake GM. Increased Airway Wall Thickness in Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2019 Apr;16(4):447-454. doi: 10.1513/AnnalsATS.201806-424OC.
PMID: 30543456DERIVEDZhang C, Ramsey C, Berical A, Yu L, Leng L, McGinnis KA, Song Y, Michael H, McCormack MC, Allore H, Morris A, Crothers K, Bucala R, Lee PJ, Sauler M. A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity. Am J Physiol Lung Cell Mol Physiol. 2019 Feb 1;316(2):L400-L405. doi: 10.1152/ajplung.00439.2018. Epub 2018 Dec 6.
PMID: 30520689DERIVEDWells JM, Parker MM, Oster RA, Bowler RP, Dransfield MT, Bhatt SP, Cho MH, Kim V, Curtis JL, Martinez FJ, Paine R 3rd, O'Neal W, Labaki WW, Kaner RJ, Barjaktarevic I, Han MK, Silverman EK, Crapo JD, Barr RG, Woodruff P, Castaldi PJ, Gaggar A; SPIROMICS and COPDGene Investigators. Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene. JCI Insight. 2018 Nov 15;3(22):e123614. doi: 10.1172/jci.insight.123614.
PMID: 30429371DERIVEDHayden LP, Cho MH, Raby BA, Beaty TH, Silverman EK, Hersh CP; COPDGene Investigators. Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study. Respir Res. 2018 Oct 29;19(1):209. doi: 10.1186/s12931-018-0890-0.
PMID: 30373671DERIVEDBoueiz A, Pham B, Chase R, Lamb A, Lee S, Naing ZZC, Cho MH, Parker MM, Sakornsakolpat P, Hersh CP, Crapo JD, Stergachis AB, Tal-Singer R, DeMeo DL, Silverman EK, Zhou X, Castaldi PJ; COPDGene investigators, by Core Units:, ECLIPSE Investigators:, GenKOLS Investigators:. Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution. Am J Respir Cell Mol Biol. 2019 Apr;60(4):388-398. doi: 10.1165/rcmb.2018-0110OC.
PMID: 30335480DERIVEDBodduluri S, Puliyakote ASK, Gerard SE, Reinhardt JM, Hoffman EA, Newell JD Jr, Nath HP, Han MK, Washko GR, San Jose Estepar R, Dransfield MT, Bhatt SP; COPDGene Investigators. Airway fractal dimension predicts respiratory morbidity and mortality in COPD. J Clin Invest. 2018 Dec 3;128(12):5374-5382. doi: 10.1172/JCI120693. Epub 2018 Oct 29.
PMID: 30256767DERIVEDJiang Y, Chen S, McGuire D, Chen F, Liu M, Iacono WG, Hewitt JK, Hokanson JE, Krauter K, Laakso M, Li KW, Lutz SM, McGue M, Pandit A, Zajac GJM, Boehnke M, Abecasis GR, Vrieze SI, Zhan X, Jiang B, Liu DJ. Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes. PLoS Genet. 2018 Jul 17;14(7):e1007452. doi: 10.1371/journal.pgen.1007452. eCollection 2018 Jul.
PMID: 30016313DERIVEDProkopenko D, Sakornsakolpat P, Fier HL, Qiao D, Parker MM, McDonald MN, Manichaikul A, Rich SS, Barr RG, Williams CJ, Brantly ML, Lange C, Beaty TH, Crapo JD, Silverman EK, Cho MH. Whole-Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2018 Nov;59(5):614-622. doi: 10.1165/rcmb.2018-0088OC.
PMID: 29949718DERIVEDBhatt SP, Kazerooni EA, Newell JD Jr, Hokanson JE, Budoff MJ, Dass CA, Martinez CH, Bodduluri S, Jacobson FL, Yen A, Dransfield MT, Fuhrman C, Nath H; COPDGene Investigators. Visual Estimate of Coronary Artery Calcium Predicts Cardiovascular Disease in COPD. Chest. 2018 Sep;154(3):579-587. doi: 10.1016/j.chest.2018.05.037. Epub 2018 Jun 8.
PMID: 29890123DERIVEDWan ES, Fortis S, Regan EA, Hokanson J, Han MK, Casaburi R, Make BJ, Crapo JD, DeMeo DL, Silverman EK; COPDGene Investigators. Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study. Am J Respir Crit Care Med. 2018 Dec 1;198(11):1397-1405. doi: 10.1164/rccm.201804-0663OC.
PMID: 29874098DERIVEDAsh SY, Harmouche R, Ross JC, Diaz AA, Rahaghi FN, Vegas Sanchez-Ferrero G, Putman RK, Hunninghake GM, Onieva Onieva J, Martinez FJ, Choi AM, Bowler RP, Lynch DA, Hatabu H, Bhatt SP, Dransfield MT, Wells JM, Rosas IO, San Jose Estepar R, Washko GR; COPDGene Investigators. Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in the COPDGene Cohort. Radiology. 2018 Aug;288(2):600-609. doi: 10.1148/radiol.2018172688. Epub 2018 Jun 5.
PMID: 29869957DERIVEDDiaz AA, Martinez CH, Harmouche R, Young TP, McDonald ML, Ross JC, Han ML, Bowler R, Make B, Regan EA, Silverman EK, Crapo J, Boriek AM, Kinney GL, Hokanson JE, Estepar RSJ, Washko GR. Pectoralis muscle area and mortality in smokers without airflow obstruction. Respir Res. 2018 Apr 10;19(1):62. doi: 10.1186/s12931-018-0771-6.
PMID: 29636050DERIVEDSakornsakolpat P, Morrow JD, Castaldi PJ, Hersh CP, Bosse Y, Silverman EK, Manichaikul A, Cho MH. Integrative genomics identifies new genes associated with severe COPD and emphysema. Respir Res. 2018 Mar 22;19(1):46. doi: 10.1186/s12931-018-0744-9.
PMID: 29566699DERIVEDAsh SY, Harmouche R, Putman RK, Ross JC, Martinez FJ, Choi AM, Bowler RP, Regan EA, Curtis JL, Han MK, Boucher RC, O'Neal WK, Hatabu H, Lynch DA, Rosas IO, Hunninghake GM, San Jose Estepar R, Washko GR; COPDGene Investigators. Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers. Thorax. 2018 Nov;73(11):1071-1074. doi: 10.1136/thoraxjnl-2017-211208. Epub 2018 Feb 13.
PMID: 29440587DERIVEDFawzy A, Putcha N, Paulin LM, Aaron CP, Labaki WW, Han MK, Wise RA, Kanner RE, Bowler RP, Barr RG, Hansel NN; SPIROMICS and COPDGene Investigators. Association of thrombocytosis with COPD morbidity: the SPIROMICS and COPDGene cohorts. Respir Res. 2018 Jan 26;19(1):20. doi: 10.1186/s12931-018-0717-z.
PMID: 29373977DERIVEDMorrow JD, Cho MH, Platig J, Zhou X, DeMeo DL, Qiu W, Celli B, Marchetti N, Criner GJ, Bueno R, Washko GR, Glass K, Quackenbush J, Silverman EK, Hersh CP. Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease. Hum Genomics. 2018 Jan 15;12(1):1. doi: 10.1186/s40246-018-0132-z.
PMID: 29335020DERIVEDBhatt SP, Kim YI, Harrington KF, Hokanson JE, Lutz SM, Cho MH, DeMeo DL, Wells JM, Make BJ, Rennard SI, Washko GR, Foreman MG, Tashkin DP, Wise RA, Dransfield MT, Bailey WC; COPDGene Investigators. Smoking duration alone provides stronger risk estimates of chronic obstructive pulmonary disease than pack-years. Thorax. 2018 May;73(5):414-421. doi: 10.1136/thoraxjnl-2017-210722. Epub 2018 Jan 11.
PMID: 29326298DERIVEDHayden LP, Hardin ME, Qiu W, Lynch DA, Strand MJ, van Beek EJ, Crapo JD, Silverman EK, Hersh CP; COPDGene Investigators( *). Asthma Is a Risk Factor for Respiratory Exacerbations Without Increased Rate of Lung Function Decline: Five-Year Follow-up in Adult Smokers From the COPDGene Study. Chest. 2018 Feb;153(2):368-377. doi: 10.1016/j.chest.2017.11.038. Epub 2017 Dec 15.
PMID: 29248621DERIVEDHalper-Stromberg E, Yun JH, Parker MM, Singer RT, Gaggar A, Silverman EK, Leach S, Bowler RP, Castaldi PJ. Systemic Markers of Adaptive and Innate Immunity Are Associated with Chronic Obstructive Pulmonary Disease Severity and Spirometric Disease Progression. Am J Respir Cell Mol Biol. 2018 Apr;58(4):500-509. doi: 10.1165/rcmb.2017-0373OC.
PMID: 29206476DERIVEDDiaz AA, Strand M, Coxson HO, Ross JC, San Jose Estepar R, Lynch D, van Rikxoort EM, Rosas IO, Hunninghake GM, Putman RK, Hatabu H, Yen A, Kinney GL, Hokanson JE, Silverman EK, Crapo J, Washko GR. Disease Severity Dependence of the Longitudinal Association Between CT Lung Density and Lung Function in Smokers. Chest. 2018 Mar;153(3):638-645. doi: 10.1016/j.chest.2017.10.012. Epub 2017 Oct 21.
PMID: 29066389DERIVEDBoueiz A, Chang Y, Cho MH, Washko GR, San Jose Estepar R, Bowler RP, Crapo JD, DeMeo DL, Dy JG, Silverman EK, Castaldi PJ; COPDGene Investigators. Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression. Chest. 2018 Jan;153(1):65-76. doi: 10.1016/j.chest.2017.09.022. Epub 2017 Sep 21.
PMID: 28943279DERIVEDBrunette AM, Holm KE, Wamboldt FS, Kozora E, Moser DJ, Make BJ, Crapo JD, Meschede K, Weinberger HD, Moreau KL, Bowler RP, Hoth KF. Subjective cognitive complaints and neuropsychological performance in former smokers with and without chronic obstructive pulmonary disease. J Clin Exp Neuropsychol. 2018 May;40(4):411-422. doi: 10.1080/13803395.2017.1356912. Epub 2017 Aug 2.
PMID: 28766459DERIVEDBodduluri S, Reinhardt JM, Hoffman EA, Newell JD Jr, Nath H, Dransfield MT, Bhatt SP; COPDGene Investigators. Signs of Gas Trapping in Normal Lung Density Regions in Smokers. Am J Respir Crit Care Med. 2017 Dec 1;196(11):1404-1410. doi: 10.1164/rccm.201705-0855OC.
PMID: 28707983DERIVEDBhatt SP, Bodduluri S, Hoffman EA, Newell JD Jr, Sieren JC, Dransfield MT, Reinhardt JM; COPDGene Investigators. Computed Tomography Measure of Lung at Risk and Lung Function Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2017 Sep 1;196(5):569-576. doi: 10.1164/rccm.201701-0050OC.
PMID: 28481639DERIVEDBhatt SP, Vegas-Sanchez-Ferrero G, Rahaghi FN, MacLean ES, Gonzalez-Serrano G, Come CE, Kinney GL, Hokanson JE, Budoff MJ, Cuttica MJ, Wells JM, Estepar RSJ, Washko GR. Cardiac Morphometry on Computed Tomography and Exacerbation Reduction with beta-Blocker Therapy in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2017 Dec 1;196(11):1484-1488. doi: 10.1164/rccm.201702-0399LE. No abstract available.
PMID: 28441027DERIVEDHodgson S, Griffin TJ, Reilly C, Harvey S, Witthuhn BA, Sandri BJ, Kunisaki KM, Wendt CH. Plasma sphingolipids in HIV-associated chronic obstructive pulmonary disease. BMJ Open Respir Res. 2017 Apr 3;4(1):e000180. doi: 10.1136/bmjresp-2017-000180. eCollection 2017.
PMID: 28409005DERIVEDMartinez CH, Freeman CM, Nelson JD, Murray S, Wang X, Budoff MJ, Dransfield MT, Hokanson JE, Kazerooni EA, Kinney GL, Regan EA, Wells JM, Martinez FJ, Han MK, Curtis JL; COPDGene Investigators. GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease. Respir Res. 2017 Feb 28;18(1):42. doi: 10.1186/s12931-017-0521-1.
PMID: 28245821DERIVEDBodduluri S, Bhatt SP, Hoffman EA, Newell JD Jr, Martinez CH, Dransfield MT, Han MK, Reinhardt JM; COPDGene Investigators. Biomechanical CT metrics are associated with patient outcomes in COPD. Thorax. 2017 May;72(5):409-414. doi: 10.1136/thoraxjnl-2016-209544. Epub 2017 Jan 2.
PMID: 28044005DERIVEDWells JM, Estepar RS, McDonald MN, Bhatt SP, Diaz AA, Bailey WC, Jacobson FL, Dransfield MT, Washko GR, Make BJ, Casaburi R, van Beek EJ, Hoffman EA, Sciurba FC, Crapo JD, Silverman EK, Hersh CP; COPDGene Investigators. Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study. BMC Pulm Med. 2016 Dec 1;16(1):169. doi: 10.1186/s12890-016-0331-0.
PMID: 27903260DERIVEDDiaz AA, Young TP, Maselli DJ, Martinez CH, Gill R, Nardelli P, Wang W, Kinney GL, Hokanson JE, Washko GR, San Jose Estepar R. Quantitative CT Measures of Bronchiectasis in Smokers. Chest. 2017 Jun;151(6):1255-1262. doi: 10.1016/j.chest.2016.11.024. Epub 2016 Nov 24.
PMID: 27890712DERIVEDBoueiz A, Lutz SM, Cho MH, Hersh CP, Bowler RP, Washko GR, Halper-Stromberg E, Bakke P, Gulsvik A, Laird NM, Beaty TH, Coxson HO, Crapo JD, Silverman EK, Castaldi PJ, DeMeo DL; COPDGene and ECLIPSE Investigators. Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Am J Respir Crit Care Med. 2017 Mar 15;195(6):757-771. doi: 10.1164/rccm.201605-0997OC.
PMID: 27669027DERIVEDDransfield MT, Kunisaki KM, Strand MJ, Anzueto A, Bhatt SP, Bowler RP, Criner GJ, Curtis JL, Hanania NA, Nath H, Putcha N, Roark SE, Wan ES, Washko GR, Wells JM, Wendt CH, Make BJ; COPDGene Investigators. Acute Exacerbations and Lung Function Loss in Smokers with and without Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2017 Feb 1;195(3):324-330. doi: 10.1164/rccm.201605-1014OC.
PMID: 27556408DERIVEDDiaz AA, Young TP, Maselli DJ, Martinez CH, Maclean ES, Yen A, Dass C, Simpson SA, Lynch DA, Kinney GL, Hokanson JE, Washko GR, San Jose Estepar R. Bronchoarterial ratio in never-smokers adults: Implications for bronchial dilation definition. Respirology. 2017 Jan;22(1):108-113. doi: 10.1111/resp.12875. Epub 2016 Aug 18.
PMID: 27538197DERIVEDHayden LP, Cho MH, McDonald MN, Crapo JD, Beaty TH, Silverman EK, Hersh CP; COPDGene Investigators *. Susceptibility to Childhood Pneumonia: A Genome-Wide Analysis. Am J Respir Cell Mol Biol. 2017 Jan;56(1):20-28. doi: 10.1165/rcmb.2016-0101OC.
PMID: 27508494DERIVEDBhatt SP, Bodduluri S, Newell JD, Hoffman EA, Sieren JC, Han MK, Dransfield MT, Reinhardt JM; COPDGene Investigators. CT-derived Biomechanical Metrics Improve Agreement Between Spirometry and Emphysema. Acad Radiol. 2016 Oct;23(10):1255-63. doi: 10.1016/j.acra.2016.02.002. Epub 2016 Apr 4.
PMID: 27055745DERIVEDBusch R, Han MK, Bowler RP, Dransfield MT, Wells JM, Regan EA, Hersh CP; COPDGene Investigators. Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort. BMC Pulm Med. 2016 Feb 10;16:28. doi: 10.1186/s12890-016-0191-7.
PMID: 26861867DERIVEDMartinez CH, Diaz AA, Parulekar AD, Rennard SI, Kanner RE, Hansel NN, Couper D, Holm KE, Hoth KF, Curtis JL, Martinez FJ, Hanania NA, Regan EA, Paine R 3rd, Cigolle CT, Han MK; COPDGene and SPIROMICS Investigators. Age-Related Differences in Health-Related Quality of Life in COPD: An Analysis of the COPDGene and SPIROMICS Cohorts. Chest. 2016 Apr;149(4):927-35. doi: 10.1016/j.chest.2015.11.025. Epub 2015 Dec 17.
PMID: 26836895DERIVEDBhatt SP, Soler X, Wang X, Murray S, Anzueto AR, Beaty TH, Boriek AM, Casaburi R, Criner GJ, Diaz AA, Dransfield MT, Curran-Everett D, Galban CJ, Hoffman EA, Hogg JC, Kazerooni EA, Kim V, Kinney GL, Lagstein A, Lynch DA, Make BJ, Martinez FJ, Ramsdell JW, Reddy R, Ross BD, Rossiter HB, Steiner RM, Strand MJ, van Beek EJ, Wan ES, Washko GR, Wells JM, Wendt CH, Wise RA, Silverman EK, Crapo JD, Bowler RP, Han MK; COPDGene Investigators. Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 Jul 15;194(2):178-84. doi: 10.1164/rccm.201511-2219OC.
PMID: 26808615DERIVEDHobbs BD, Parker MM, Chen H, Lao T, Hardin M, Qiao D, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Castaldi PJ, Hersh CP, Morrow J, Celli BR, Pinto-Plata VM, Criner GJ, Marchetti N, Bueno R, Agusti A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Pare PD, Levy RD, Rennard SI, Zhou X, Laird NM, Lin X, Beaty TH, Silverman EK, Cho MH; NETT Genetics Investigators; ECLIPSE Investigators; COPDGene Investigators; International COPD Genetics Network Investigators. Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 Jul 1;194(1):48-57. doi: 10.1164/rccm.201510-2053OC.
PMID: 26771213DERIVEDQiao D, Lange C, Beaty TH, Crapo JD, Barnes KC, Bamshad M, Hersh CP, Morrow J, Pinto-Plata VM, Marchetti N, Bueno R, Celli BR, Criner GJ, Silverman EK, Cho MH; Lung GO; NHLBI Exome Sequencing Project; COPDGene Investigators. Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 Jun 15;193(12):1353-63. doi: 10.1164/rccm.201506-1223OC.
PMID: 26736064DERIVEDLutz SM, Cho MH, Young K, Hersh CP, Castaldi PJ, McDonald ML, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ, Jensen RL, Casaburi R, Lomas DA, Bhatt SP, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Laird NM, Lange C, Hokanson JE, Silverman EK; ECLIPSE Investigators; COPDGene Investigators. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet. 2015 Dec 3;16:138. doi: 10.1186/s12863-015-0299-4.
PMID: 26634245DERIVEDHayden LP, Hobbs BD, Cohen RT, Wise RA, Checkley W, Crapo JD, Hersh CP; COPDGene Investigators. Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study. Respir Res. 2015 Sep 21;16(1):115. doi: 10.1186/s12931-015-0273-8.
PMID: 26392057DERIVEDBhatt SP, Wells JM, Kinney GL, Washko GR Jr, Budoff M, Kim YI, Bailey WC, Nath H, Hokanson JE, Silverman EK, Crapo J, Dransfield MT; COPDGene Investigators. beta-Blockers are associated with a reduction in COPD exacerbations. Thorax. 2016 Jan;71(1):8-14. doi: 10.1136/thoraxjnl-2015-207251. Epub 2015 Aug 17.
PMID: 26283710DERIVEDBatmanghelich NK, Saeedi A, Cho M, Estepar RS, Golland P. Generative Method to Discover Genetically Driven Image Biomarkers. Inf Process Med Imaging. 2015;24:30-42. doi: 10.1007/978-3-319-19992-4_3.
PMID: 26221665DERIVEDCho MH, Castaldi PJ, Hersh CP, Hobbs BD, Barr RG, Tal-Singer R, Bakke P, Gulsvik A, San Jose Estepar R, Van Beek EJ, Coxson HO, Lynch DA, Washko GR, Laird NM, Crapo JD, Beaty TH, Silverman EK; NETT Genetics, ECLIPSE, and COPDGene Investigators. A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am J Respir Crit Care Med. 2015 Sep 1;192(5):559-69. doi: 10.1164/rccm.201501-0148OC.
PMID: 26030696DERIVEDWells JM, Iyer AS, Rahaghi FN, Bhatt SP, Gupta H, Denney TS, Lloyd SG, Dell'Italia LJ, Nath H, Estepar RS, Washko GR, Dransfield MT. Pulmonary artery enlargement is associated with right ventricular dysfunction and loss of blood volume in small pulmonary vessels in chronic obstructive pulmonary disease. Circ Cardiovasc Imaging. 2015 Apr;8(4):10.1161/CIRCIMAGING.114.002546 e002546. doi: 10.1161/CIRCIMAGING.114.002546.
PMID: 25855668DERIVEDHersh CP, Make BJ, Lynch DA, Barr RG, Bowler RP, Calverley PM, Castaldi PJ, Cho MH, Coxson HO, DeMeo DL, Foreman MG, Han MK, Harshfield BJ, Hokanson JE, Lutz S, Ramsdell JW, Regan EA, Rennard SI, Schroeder JD, Sciurba FC, Steiner RM, Tal-Singer R, van Beek E Jr, Silverman EK, Crapo JD; COPDGene and ECLIPSE Investigators. Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med. 2014 Oct 24;14:164. doi: 10.1186/1471-2466-14-164.
PMID: 25341556DERIVEDDiaz AA, Hardin ME, Come CE, San Jose Estepar R, Ross JC, Kurugol S, Okajima Y, Han MK, Kim V, Ramsdell J, Silverman EK, Crapo JD, Lynch DA, Make B, Barr RG, Hersh CP, Washko GR; COPDGene Investigators. Childhood-onset asthma in smokers. association between CT measures of airway size, lung function, and chronic airflow obstruction. Ann Am Thorac Soc. 2014 Nov;11(9):1371-8. doi: 10.1513/AnnalsATS.201403-095OC.
PMID: 25296268DERIVEDHobbs BD, Foreman MG, Bowler R, Jacobson F, Make BJ, Castaldi PJ, San Jose Estepar R, Silverman EK, Hersh CP; COPDGene Investigators. Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2014 Nov;11(9):1387-94. doi: 10.1513/AnnalsATS.201405-224OC.
PMID: 25295410DERIVEDLee JH, Cho MH, Hersh CP, McDonald ML, Crapo JD, Bakke PS, Gulsvik A, Comellas AP, Wendt CH, Lomas DA, Kim V, Silverman EK; COPDGene and ECLIPSE Investigators. Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. Respir Res. 2014 Sep 21;15(1):113. doi: 10.1186/s12931-014-0113-2.
PMID: 25241909DERIVEDLee JH, McDonald ML, Cho MH, Wan ES, Castaldi PJ, Hunninghake GM, Marchetti N, Lynch DA, Crapo JD, Lomas DA, Coxson HO, Bakke PS, Silverman EK, Hersh CP; COPDGene and ECLIPSE Investigators. DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease. Respir Res. 2014 Aug 20;15(1):97. doi: 10.1186/s12931-014-0097-y.
PMID: 25134640DERIVEDWan ES, Castaldi PJ, Cho MH, Hokanson JE, Regan EA, Make BJ, Beaty TH, Han MK, Curtis JL, Curran-Everett D, Lynch DA, DeMeo DL, Crapo JD, Silverman EK; COPDGene Investigators. Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res. 2014 Aug 6;15(1):89. doi: 10.1186/s12931-014-0089-y.
PMID: 25096860DERIVEDBhatt SP, Sieren JC, Newell JD Jr, Comellas AP, Hoffman EA. Disproportionate contribution of right middle lobe to emphysema and gas trapping on computed tomography. PLoS One. 2014 Jul 23;9(7):e102807. doi: 10.1371/journal.pone.0102807. eCollection 2014.
PMID: 25054539DERIVEDCastaldi PJ, Cho MH, San Jose Estepar R, McDonald ML, Laird N, Beaty TH, Washko G, Crapo JD, Silverman EK; COPDGene Investigators. Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. Am J Respir Crit Care Med. 2014 Aug 15;190(4):399-409. doi: 10.1164/rccm.201403-0569OC.
PMID: 25006744DERIVEDMcDonald ML, Cho MH, Sorheim IC, Lutz SM, Castaldi PJ, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard SI, Wouters EF, Bakke P, Tal-Singer R, Miller BE, Gulsvik A, Casaburi R, Wells JM, Regan EA, Make BJ, Hokanson JE, Lange C, Crapo JD, Beaty TH, Silverman EK, Hersh CP; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints and COPDGene Investigators. Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2014 Nov;51(5):678-87. doi: 10.1165/rcmb.2014-0135OC.
PMID: 24825563DERIVEDManichaikul A, Hoffman EA, Smolonska J, Gao W, Cho MH, Baumhauer H, Budoff M, Austin JH, Washko GR, Carr JJ, Kaufman JD, Pottinger T, Powell CA, Wijmenga C, Zanen P, Groen HJ, Postma DS, Wanner A, Rouhani FN, Brantly ML, Powell R, Smith BM, Rabinowitz D, Raffel LJ, Hinckley Stukovsky KD, Crapo JD, Beaty TH, Hokanson JE, Silverman EK, Dupuis J, O'Connor GT, Boezen HM, Rich SS, Barr RG. Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. Am J Respir Crit Care Med. 2014 Feb 15;189(4):408-18. doi: 10.1164/rccm.201306-1061OC.
PMID: 24383474DERIVEDHan MK, Muellerova H, Curran-Everett D, Dransfield MT, Washko GR, Regan EA, Bowler RP, Beaty TH, Hokanson JE, Lynch DA, Jones PW, Anzueto A, Martinez FJ, Crapo JD, Silverman EK, Make BJ. GOLD 2011 disease severity classification in COPDGene: a prospective cohort study. Lancet Respir Med. 2013 Mar;1(1):43-50. doi: 10.1016/S2213-2600(12)70044-9. Epub 2012 Sep 3.
PMID: 24321803DERIVEDMartinez CH, Kim V, Chen Y, Kazerooni EA, Murray S, Criner GJ, Curtis JL, Regan EA, Wan E, Hersh CP, Silverman EK, Crapo JD, Martinez FJ, Han MK; COPDGene Investigators. The clinical impact of non-obstructive chronic bronchitis in current and former smokers. Respir Med. 2014 Mar;108(3):491-9. doi: 10.1016/j.rmed.2013.11.003. Epub 2013 Nov 15.
PMID: 24280543DERIVEDDiaz AA, Han MK, Come CE, San Jose Estepar R, Ross JC, Kim V, Dransfield MT, Curran-Everett D, Schroeder JD, Lynch DA, Tschirren J, Silverman EK, Washko GR. Effect of emphysema on CT scan measures of airway dimensions in smokers. Chest. 2013 Mar;143(3):687-693. doi: 10.1378/chest.12-0039.
PMID: 23460155DERIVEDWells JM, Washko GR, Han MK, Abbas N, Nath H, Mamary AJ, Regan E, Bailey WC, Martinez FJ, Westfall E, Beaty TH, Curran-Everett D, Curtis JL, Hokanson JE, Lynch DA, Make BJ, Crapo JD, Silverman EK, Bowler RP, Dransfield MT; COPDGene Investigators; ECLIPSE Study Investigators. Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med. 2012 Sep 6;367(10):913-21. doi: 10.1056/NEJMoa1203830. Epub 2012 Sep 3.
PMID: 22938715DERIVEDDoyle TJ, Washko GR, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Divo MJ, Celli BR, Sciurba FC, Silverman EK, Hatabu H, Rosas IO, Hunninghake GM; COPDGene Investigators. Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med. 2012 Apr 1;185(7):756-62. doi: 10.1164/rccm.201109-1618OC. Epub 2012 Jan 20.
PMID: 22268134DERIVEDXu JF, Washko GR, Nakahira K, Hatabu H, Patel AS, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estepar RS, Diaz AA, Li HP, Qu JM, Himes BE, Come CE, D'Aco K, Martinez FJ, Han MK, Lynch DA, Crapo JD, Morse D, Ryter SW, Silverman EK, Rosas IO, Choi AM, Hunninghake GM; COPDGene Investigators. Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med. 2012 Mar 1;185(5):547-56. doi: 10.1164/rccm.201108-1574OC. Epub 2012 Jan 12.
PMID: 22246178DERIVEDHardin M, Silverman EK, Barr RG, Hansel NN, Schroeder JD, Make BJ, Crapo JD, Hersh CP; COPDGene Investigators. The clinical features of the overlap between COPD and asthma. Respir Res. 2011 Sep 27;12(1):127. doi: 10.1186/1465-9921-12-127.
PMID: 21951550DERIVEDDiaz AA, Come CE, Ross JC, San Jose Estepar R, Han MK, Loring SH, Silverman EK, Washko GR; COPDGene Investigators. Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPD. Chest. 2012 Mar;141(3):736-744. doi: 10.1378/chest.11-1026. Epub 2011 Sep 22.
PMID: 21940776DERIVEDHan MK, Curran-Everett D, Dransfield MT, Criner GJ, Zhang L, Murphy JR, Hansel NN, DeMeo DL, Hanania NA, Regan EA, Make BJ, Martinez FJ, Westney GE, Foreman MG; COPDGene Investigators. Racial differences in quality of life in patients with COPD. Chest. 2011 Nov;140(5):1169-1176. doi: 10.1378/chest.10-2869. Epub 2011 Jun 2.
PMID: 21636665DERIVEDWan ES, Hokanson JE, Murphy JR, Regan EA, Make BJ, Lynch DA, Crapo JD, Silverman EK; COPDGene Investigators. Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study. Am J Respir Crit Care Med. 2011 Jul 1;184(1):57-63. doi: 10.1164/rccm.201101-0021OC. Epub 2011 Apr 14.
PMID: 21493737DERIVEDKim V, Han MK, Vance GB, Make BJ, Newell JD, Hokanson JE, Hersh CP, Stinson D, Silverman EK, Criner GJ; COPDGene Investigators. The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study. Chest. 2011 Sep;140(3):626-633. doi: 10.1378/chest.10-2948. Epub 2011 Apr 7.
PMID: 21474571DERIVEDKim DK, Jacobson FL, Washko GR, Casaburi R, Make BJ, Crapo JD, Silverman EK, Hersh CP. Clinical and radiographic correlates of hypoxemia and oxygen therapy in the COPDGene study. Respir Med. 2011 Aug;105(8):1211-21. doi: 10.1016/j.rmed.2011.02.015. Epub 2011 Mar 10.
PMID: 21396809DERIVEDWashko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estepar RS, Lynch DA, Brehm JM, Andriole KP, Diaz AA, Khorasani R, D'Aco K, Sciurba FC, Silverman EK, Hatabu H, Rosas IO; COPDGene Investigators. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med. 2011 Mar 10;364(10):897-906. doi: 10.1056/NEJMoa1007285.
PMID: 21388308DERIVEDKim DK, Hersh CP, Washko GR, Hokanson JE, Lynch DA, Newell JD, Murphy JR, Crapo JD, Silverman EK; COPD Gene Investigators. Epidemiology, radiology, and genetics of nicotine dependence in COPD. Respir Res. 2011 Jan 13;12(1):9. doi: 10.1186/1465-9921-12-9.
PMID: 21232152DERIVED
Biospecimen
Genomic DNA, RNA, serum, and plasma will be collected and stored.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
James D. Crapo, MD
National Jewish Health
- PRINCIPAL INVESTIGATOR
Edwin K. Silverman, MD, PhD
Brigham and Women's Hospital
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Medicine
Study Record Dates
First Submitted
January 28, 2008
First Posted
February 6, 2008
Study Start
November 1, 2007
Primary Completion (Estimated)
August 1, 2028
Study Completion (Estimated)
August 1, 2028
Last Updated
September 17, 2025
Record last verified: 2025-09
Data Sharing
- IPD Sharing
- Will share
COPDGene phenotypic and genotypic data are available through dbGaP.