Alcohol Use Disorders (AUDs) and Post-traumatic Stress Disorder (PTSD) Treatment for Victims of Partner Violence

NCT00607412 | Completed Phase 2 DMC

• 1 other identifier: K23AA015707
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to evaluate a psychotherapy for PTSD and substance use disorders among women who have experienced domestic violence. The hypothesis is that women who receive present-focused, integrated treatment will have greater PTSD symptom reduction and have less substance use after treatment than women in the control condition who will receive supportive therapy based on a 12-step approach.

Conditions

PTSD; Substance Use Disorders

Keywords

PTSD; substance use disorders; psychotherapy

Outcome Measures

Primary Outcomes (1)

• CAPS for PTSD symptoms and ASI for substance use

  pre, mid treatment, post, 3-month follow-up, 6-month follow-up

Secondary Outcomes (1)

• Timeline Follow-back procedure, Beck Depression Inventory

  same as primary

Study Arms (2)

1

EXPERIMENTAL

Present focused, integrated psychotherapy for PTSD and substance use disorders

Behavioral: Integrated psychotherapy for PTSD and substance use

2

ACTIVE COMPARATOR

Supportive therapy using 12-step model

Behavioral: 12-step based supportive therapy

Interventions

Integrated psychotherapy for PTSD and substance use BEHAVIORAL

integrated, present focused psychotherapy for PTSD and substance use disorders tailored to women who have experienced intimate partner violence

1

12-step based supportive therapy BEHAVIORAL

supportive psychotherapy based on 12-step model

2

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• female victims of partner violence
• at least one month out of the abusive relationship
• meet DSM-IV (American Psychiatric Association, 1994) criteria for PTSD and an alcohol use disorder
• literate in English
• have not changed psychotropic medications or dosages within the past two months and agree not to during the active phase (first 12 weeks) of the intervention
• have an identified primary care physician

You may not qualify if:

• moderate or severe cognitive impairment as measured by a Mini-Mental State Examination score less than or equal to 18
• Histories of psychosis or mania may be excluded because the presence of these disorders is thought to impede progress in psychotherapy

Sponsors & Collaborators

• University of California, San Diego: lead

Study Sites (1)

UCSD Outpatient Psychiatry

San Diego, California, 92103, United States

Location

Related Publications (2)

• Hameed M, O'Doherty L, Gilchrist G, Tirado-Munoz J, Taft A, Chondros P, Feder G, Tan M, Hegarty K. Psychological therapies for women who experience intimate partner violence. Cochrane Database Syst Rev. 2020 Jul 1;7(7):CD013017. doi: 10.1002/14651858.CD013017.pub2.

  PMID: 32608505 DERIVED

• Myers US, Browne KC, Norman SB. Treatment Engagement: Female Survivors of Intimate Partner Violence in Treatment for PTSD and Alcohol Use Disorder. J Dual Diagn. 2015;11(3-4):238-47. doi: 10.1080/15504263.2015.1113762.

  PMID: 26515712 DERIVED

MeSH Terms

Conditions

Stress Disorders, Post-Traumatic; Substance-Related Disorders

Condition Hierarchy (Ancestors)

Stress Disorders, Traumatic; Trauma and Stressor Related Disorders; Mental Disorders; Chemically-Induced Disorders

Study Officials

• Sonya Norman

  UCSD

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 26, 2007
• First Posted: February 5, 2008
• Study Start: August 1, 2007
• Primary Completion: May 1, 2011
• Study Completion: May 1, 2011
• Last Updated: May 11, 2011

Record last verified: 2009-06

Locations

US (1)