Examining the Biological Factors That Affect Sleep Duration
Neurobiology of Individual Differences in Sleep Duration
2 other identifiers
observational
119
1 country
1
Brief Summary
Sleep is necessary for healthy functioning, and people who sleep too little or too much may have an increased risk of developing health problems. This study will examine people who regularly sleep for short or long amounts of time to understand the biological factors that determine how much sleep a person needs.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Oct 2005
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2005
CompletedFirst Submitted
Initial submission to the registry
February 4, 2008
CompletedFirst Posted
Study publicly available on registry
February 5, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2011
CompletedJuly 31, 2013
July 1, 2013
6.1 years
February 4, 2008
July 30, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Circadian rhythm assessment based on plasma melatonin and other hormones; sleep and EEG analysis; measurements of cognitive performance, alertness, and mood
Measured during the 4-week inpatient stay
Eligibility Criteria
Participants will include healthy people who are catagorized as either short sleepers or long sleepers.
You may qualify if:
- Routinely sleeps 6.5 hours or less a night, or routinely sleeps 9 hours or more a night
- In good health
You may not qualify if:
- Diagnosed with a sleep disorder
- Currently uses medications
- Performed night shift work in the 3 years before study entry
- History of psychiatric illness
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Brigham & Women's Hospital
Boston, Massachusetts, 02115, United States
Related Publications (3)
Aeschbach D, Sher L, Postolache TT, Matthews JR, Jackson MA, Wehr TA. A longer biological night in long sleepers than in short sleepers. J Clin Endocrinol Metab. 2003 Jan;88(1):26-30. doi: 10.1210/jc.2002-020827.
PMID: 12519823BACKGROUNDAeschbach D, Postolache TT, Sher L, Matthews JR, Jackson MA, Wehr TA. Evidence from the waking electroencephalogram that short sleepers live under higher homeostatic sleep pressure than long sleepers. Neuroscience. 2001;102(3):493-502. doi: 10.1016/s0306-4522(00)00518-2.
PMID: 11226688BACKGROUNDAeschbach D, Cajochen C, Landolt H, Borbely AA. Homeostatic sleep regulation in habitual short sleepers and long sleepers. Am J Physiol. 1996 Jan;270(1 Pt 2):R41-53. doi: 10.1152/ajpregu.1996.270.1.R41.
PMID: 8769783BACKGROUND
Related Links
Biospecimen
Plasma samples
Study Officials
- PRINCIPAL INVESTIGATOR
Daniel Aeschbach, PhD
Brigham & Women's Hospital, Boston, MA
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Neuroscientist
Study Record Dates
First Submitted
February 4, 2008
First Posted
February 5, 2008
Study Start
October 1, 2005
Primary Completion
November 1, 2011
Study Completion
November 1, 2011
Last Updated
July 31, 2013
Record last verified: 2013-07