Effects of Different Colors of Light on Human Physiology
Mechanism Underlying the Effects of Blue Light in Humans
1 other identifier
interventional
47
1 country
1
Brief Summary
This study will determine which color of light is most effective in stimulating a range of biological functions in humans including activation of sleep-wake regulatory system (alertness, performance, microsleeps, brain activity), activation of the nervous system (heart rate, temperature, blood pressure, breathing rate), and shifting the timing of the internal 24-hour (circadian) pacemaker.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable healthy
Started Apr 2005
Typical duration for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2005
CompletedFirst Submitted
Initial submission to the registry
September 12, 2005
CompletedFirst Posted
Study publicly available on registry
September 20, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2007
CompletedAugust 12, 2014
August 1, 2014
1.8 years
September 12, 2005
August 8, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (6)
Subjective alertness prior to, during and after light exposure
9.5 hours
Auditory psychomotor performance prior to, during and after light exposure
9.5 hours
EEG power frequency prior to, during and after light exposure
9.5 hours
Plasma melatonin and cortisol prior to, during and after light exposure
60 hours
Heart rate, blood pressure, respiration rate and temperature prior to, during and after light exposure
9.5 hours
Urinary catecholamines prior to, during and after light exposure
32 hours
Study Arms (6)
1
EXPERIMENTAL420 nm light
2
EXPERIMENTAL480 nm
3
EXPERIMENTAL507 nm
4
EXPERIMENTAL555 nm
5
EXPERIMENTAL620 nm
6
EXPERIMENTAL460 nm
Interventions
Monochromatic light in the visible range from 420-620 nm up to 60uW/cm2 for 6.5 hours
Eligibility Criteria
You may qualify if:
- Free from any acute, chronic or debilitating medical, psychological, or ophthalmological conditions
- Drug-free (including caffeine, nicotine, and alcohol) for entire study duration
You may not qualify if:
- History of drug or alcohol dependency
- History of psychiatric illnesses or evidence of psychopathology according to standardized questionnaires, or in a structured clinical interview
- Night shift work during the past 3 years
- Transmeridian travel in the last 3 months
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Division of Sleep Medicine, Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
Related Publications (1)
Gooley JJ, Chamberlain K, Smith KA, Khalsa SB, Rajaratnam SM, Van Reen E, Zeitzer JM, Czeisler CA, Lockley SW. Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. J Clin Endocrinol Metab. 2011 Mar;96(3):E463-72. doi: 10.1210/jc.2010-2098. Epub 2010 Dec 30.
PMID: 21193540DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Steven W Lockley, Ph.D.
Brigham and Women's Hospital, Harvard Medical School
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Neuroscientist
Study Record Dates
First Submitted
September 12, 2005
First Posted
September 20, 2005
Study Start
April 1, 2005
Primary Completion
February 1, 2007
Study Completion
February 1, 2007
Last Updated
August 12, 2014
Record last verified: 2014-08