Mechanisms of Acute Asthma Exacerbations Through Molecular Analysis of Airway Secretions and Tissues

NCT00603629 | Completed

• 1 other identifier: H6788-31516-01
• Study Type: observational
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate mechanisms which cause acute asthma exacerbations by examining blood and airway secretions during an acute onset (sputum or tracheal aspirates). This pilot study is intended to uncover new mechanisms of asthma exacerbation and to generate hypotheses for future study. By collaborating with Genentech, we (scientists at UCSF) plan to incorporate the latest scientific findings into our work to discover and develop new treatments for asthma.

Conditions

Asthma

Keywords

Acute Asthma

Outcome Measures

Primary Outcomes (1)

• gene expression in blood and airway secretions and tissues

  Comparison of gene expression in blood and airway secretions and tissues during acute asthma exacerbation to recovery

  6 - 10 weeks

Study Arms (1)

I

People with acute asthma in the Emergency department or inpatient settings

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

People with acute asthma who seek treatment in the Emergency Department or who require admission to the hospital for their asthma

You may qualify if:

• Male and female subjects aged 18 - 70 years
• Medical history of asthma
• Currently experiencing an acute exacerbation of asthma
• Ability to provide informed consent or have a surrogate provide consent.
• Ability to provide sputum.

You may not qualify if:

• Cigarette smoking: Subjects must be non-smokers. Non-smokers are defined as subjects who have never smoked or who have not smoked for 1 year and have a total pack-year smoking history \< 10 packs.
• Pregnant women.

Sponsors & Collaborators

• University of California, San Francisco: lead
• Genentech, Inc.: collaborator

Study Sites (1)

UCSF Airway Clinical Research Center

San Francisco, California, 94143, United States

Location

Related Links

• UCSF Airway Clinical Research Center website

Biospecimen

Retention: SAMPLES WITH DNA

whole blood, DNA, RNA, sputum, nasopharyngeal swab

MeSH Terms

Conditions

Asthma

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• John V Fahy, M.D., M.Sc.

  University of California, San Francisco

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor in Residence

Study Record Dates

• First Submitted: January 16, 2008
• First Posted: January 29, 2008
• Study Start: January 1, 2008
• Primary Completion: September 1, 2009
• Study Completion: September 1, 2009
• Last Updated: May 1, 2026

Record last verified: 2011-09

Locations

US (1)