Language Function in Patients With Brain Tumors

NCT00599703 | Completed

• 1 other identifier: 05-043
• Study Type: observational
• Target: 7
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to use an imaging method called functional magnetic resonance imaging (fMRI) in patients who have a tumor near an area of the brain that is believed to control language. The fMRI is a new kind of imaging that uses a strong magnetic field to look at functioning brain tissue. This kind of imaging will be used to study the effect of the brain tumor on your speech.

Conditions

Brain Cancer; CNS Cancer

Outcome Measures

Primary Outcomes (1)

• To identify language organization prior to surgery in patients in whom a tumor invades or is directly adjacent to the expected location of one of the language centers.

  conclusion of study

Secondary Outcomes (1)

• To assess language reorganization over time.

  conclusion of study

Study Arms (1)

1

neurosurgical patients

Other: fMRI Scan, pre- and post language evaluation

Interventions

fMRI Scan, pre- and post language evaluation OTHER

All subjects will undergo functional MR imaging, pre- and post-surgical language evaluation, and electrocortical stimulation mapping. The brain tumor patients will undergo these procedures twice.

1

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

MSKCC clinics

You may qualify if:

• Patient in whom a tumor invades or is directly adjacent to the expected location of one of the language centers.
• At least 18 years of age
• English as first language

You may not qualify if:

• Patients with high grade tumors
• History of significant psychiatric condition (e.g. schizophrenia, obsessive-compulsive disorder, significant dementia),
• History of the following neurological conditions: CVA, demyelinating conditions, cerebral palsy, Alzheimer's disease.
• History of significant claustrophobic reactions.
• Pregnancy
• Standard contraindications to MR examinations (e.g. implanted stimulator)
• Patients, who were treated prior to our first scan, will not be eligible to participate in this study

Sponsors & Collaborators

• Memorial Sloan Kettering Cancer Center: lead

Study Sites (1)

Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

Location

Related Links

• Memorial Sloan-Kettering Cancer Center

MeSH Terms

Conditions

Brain Neoplasms; Central Nervous System Neoplasms

Interventions

Lead

Condition Hierarchy (Ancestors)

Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Metals, Heavy; Elements; Inorganic Chemicals; Metals

Study Officials

• Andrei Holodny, MD

  Memorial Sloan Kettering Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: January 11, 2008
• First Posted: January 24, 2008
• Study Start: May 1, 2005
• Primary Completion: March 1, 2009
• Study Completion: March 1, 2009
• Last Updated: July 8, 2009

Record last verified: 2009-07

Locations

US (1)