Management of Patients With Atrial Fibrillation Undergoing Coronary Artery Stenting

NCT00596570 | Completed

• 1 other identifier: 12007
• Study Type: observational
• Target: 996
• Locations: 1 country
• Sites: 1

Brief Summary

Treatment of patients suffering from atrial fibrillation pose problems when percutaneous coronary intervention with stent implantation (PCI-S) is performed. In the absence of solid evidence-based data, no definite recommendations for the management of this patient subset are currently given in the guidelines on percutaneous coronary intervention issued by the most prominent Cardiology Associations. The management of the antithrombotic treatment before invasive cardiac procedures is also incompletely defined. In this study we aim to determine in patients with atrial fibrillation undergoing PCI-S:

1. 1.the contemporary antithrombotic management;
2. 2.the relative safety and efficacy of the various post-PCI antithrombotic regimens;
3. 3.the safety and efficacy of drug-eluting stents (DES), bare-metal stents (BMS), and bioactive stents (BAS);
4. 4.the safety of various periprocedural antithrombotic strategies including glycoprotein IIb/IIIa inhibitors and bivalirudin;
5. 5.safety and efficacy of radial vs femoral approach.

Conditions

Atrial Fibrillation; Oral Anticoagulation; Percutaneous Coronary Intervention

Keywords

Atrial fibrillation; Oral Anticoagulation; Percutaneous coronary intervention

Outcome Measures

Primary Outcomes (1)

• major hemorrhagic and thrombotic/thromboembolic complications including cardiac death

  one year

Study Arms (1)

1

Patient with atrial fibrillation who underwent PCI

Procedure: PCI

Interventions

PCI PROCEDURE

Percutaneous coronary interventiom

1

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with atrial fibrillation undergoing PCI-S.

You may qualify if:

• Patients with atrial fibrillation who undergo PCI.

Sponsors & Collaborators

• University of Turku: lead

Study Sites (1)

Juhani Airaksinen

Turku, 20520, Finland

Location

Related Publications (3)

• Puurunen M, Kiviniemi T, Nammas W, Schlitt A, Rubboli A, Nyman K, Karjalainen P, Kirchhof P, Lip GY, Airaksinen JK. Impact of anaemia on clinical outcome in patients with atrial fibrillation undergoing percutaneous coronary intervention: insights from the AFCAS registry. BMJ Open. 2014 May 13;4(5):e004700. doi: 10.1136/bmjopen-2013-004700.

  PMID: 24823675 DERIVED

• Rubboli A, Schlitt A, Kiviniemi T, Biancari F, Karjalainen PP, Valencia J, Laine M, Kirchhof P, Niemela M, Vikman S, Lip GY, Airaksinen KE; AFCAS Study Group. One-year outcome of patients with atrial fibrillation undergoing coronary artery stenting: an analysis of the AFCAS registry. Clin Cardiol. 2014 Jun;37(6):357-64. doi: 10.1002/clc.22254. Epub 2014 Jan 30.

  PMID: 24481953 DERIVED

• Schlitt A, Rubboli A, Lip GY, Lahtela H, Valencia J, Karjalainen PP, Weber M, Laine M, Kirchhof P, Niemela M, Vikman S, Buerke M, Airaksinen KE; AFCAS (Management of patients with Atrial Fibrillation undergoing Coronary Artery Stenting Study Group). The management of patients with atrial fibrillation undergoing percutaneous coronary intervention with stent implantation: in-hospital-data from the Atrial Fibrillation undergoing Coronary Artery Stenting study. Catheter Cardiovasc Interv. 2013 Dec 1;82(7):E864-70. doi: 10.1002/ccd.25064. Epub 2013 Aug 28.

  PMID: 23765437 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Anticoagulation samples

MeSH Terms

Conditions

Atrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Juhani KE Airaksinen, Professor

  University of Turku

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: January 8, 2008
• First Posted: January 17, 2008
• Study Start: January 1, 2007
• Study Completion: February 1, 2010
• Last Updated: June 30, 2010

Record last verified: 2007-12

Locations

FI (1)