A Unified Treatment for Anxiety Disorders

NCT00586001 | Completed Results

• 1 other identifier: 5R34MH070693-02
• Study Type: interventional
• Target: 37
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to develop a new psychological therapy for a variety of different types of emotional disorders. The study will compare symptoms and functioning of clients who receive the treatment with those who do not, and will include a number of assessments before, during, and after treatment. We predict that patients receiving active treatment will show improved functioning relative to wait-list control.

Conditions

Emotional Disorders; Anxiety Disorders

Keywords

Anxiety; Emotional Disorders; Unified; Depression

Outcome Measures

Primary Outcomes (1)

• Anxiety Disorders Interview Schedule for DSM-IV

  DSM-IV diagnoses of anxiety disorders. Principal and additional diagnoses are assigned a clinical severity rating (CSR) on a scale from 0 (no symptoms) to 8 (extremely severe symptoms), with a rating of 4 or above (definitely disturbing/disabling) passing the clinical threshold for DSM-IV diagnostic criteria.

  Measured at pre-treatment (baseline) and post-treatment (month 3)

Secondary Outcomes (18)

• Structured Interview Guide for the Hamilton Anxiety Rating Scale

  Measured at pre-treatment (baseline) and post-treatment (month 3)

• Structured Interview Guide for the Hamilton Depression Rating Scale

  Measured at pre-treatment (baseline) and post-treatment (month 3)

• Positive and Negative Affect Scale

  Measured at pre-treatment (baseline) and post-treatment (month 3)

• Beck Depression Inventory - II

  Measured at pre-treatment (baseline) and post-treatment (month 3)

• Beck Anxiety Inventory

  Measured at pre-treatment (baseline) and post-treatment (month 3)

Study Arms (2)

1

EXPERIMENTAL

Unified Protocol for Transdiagnostic Treatment of Emotional Disorders The UP is a form of transdiagnostic cognitive-behavioral therapy (CBT) for individuals diagnosed with anxiety disorders, depression and related disorders.

Behavioral: Unified Protocol for Transdiagnostic Treatment of Emotional Disorders

2

NO INTERVENTION

Wait-list control: Participants were asked to wait 16 weeks before receiving treatment.

Interventions

Unified Protocol for Transdiagnostic Treatment of Emotional Disorders BEHAVIORAL

Cognitive-behavioral treatment in development for emotional disorders

1

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Primary Diagnosis of a DSM-IV Anxiety Disorder

You may not qualify if:

• Previous treatment with cognitive-behavioral therapy
• Receiving concurrent psychological treatments during study
• If on psychotropic medicine, requirement for stable dose for at least three months before treatment

Sponsors & Collaborators

• Boston University Charles River Campus: lead

Related Publications (4)

• Brown TA, Chorpita BF, Barlow DH. Structural relationships among dimensions of the DSM-IV anxiety and mood disorders and dimensions of negative affect, positive affect, and autonomic arousal. J Abnorm Psychol. 1998 May;107(2):179-92. doi: 10.1037//0021-843x.107.2.179.

  PMID: 9604548 BACKGROUND

• Brown TA, Campbell LA, Lehman CL, Grisham JR, Mancill RB. Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample. J Abnorm Psychol. 2001 Nov;110(4):585-99. doi: 10.1037//0021-843x.110.4.585.

  PMID: 11727948 BACKGROUND

• Barlow DH. Unraveling the mysteries of anxiety and its disorders from the perspective of emotion theory. Am Psychol. 2000 Nov;55(11):1247-63. doi: 10.1037//0003-066x.55.11.1247.

  PMID: 11280938 BACKGROUND

• Barlow, D.H., Allen, L., & Choate, M.L. (2006). The Unified Protocol for Treatment of the Emotional Disorders. Unpublished manuscript, Boston University.

  BACKGROUND

Related Links

• Center for Anxiety and Related Disorders at Boston University webpage

MeSH Terms

Conditions

Anxiety Disorders; Depression

Condition Hierarchy (Ancestors)

Mental Disorders; Behavioral Symptoms; Behavior

Results Point of Contact

• Title: Todd Farchione
• Organization: Boston University Charles River Campus

tfarchio@bu.edu

(617) 353-9610

Study Officials

• David H Barlow, Ph.D

  Boston University Center for Anxiety and Related Disorders

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Psychology and Psychiatry, Emeritus

Model Details: Treatment with the Unified Protocol (Arm 1) compared to a 16-week wait list control condition (Arm 2).

Study Record Dates

• First Submitted: December 21, 2007
• First Posted: January 4, 2008
• Study Start: September 1, 2005
• Primary Completion: November 1, 2008
• Study Completion: November 1, 2010
• Last Updated: December 11, 2018
• Results First Posted: December 11, 2018

Record last verified: 2018-11