Age and Endothelial Progenitor Cell Mobilization
AGE-PCI
The Effects of Age on Endothelial Progenitor Cell Mobilization in Humans
1 other identifier
observational
123
1 country
2
Brief Summary
It is hypothesized that aging is associated with reduced vascular injury-induced endothelial progenitor cell activity, resulting in impaired vascular repair and increased vascular disease. Patients with stable coronary artery disease will be enrolled in this observational study and will undergo either angiography alone or angiography and angioplasty. Participants will be followed for 5 years.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jul 2006
Typical duration for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2006
CompletedFirst Submitted
Initial submission to the registry
December 21, 2007
CompletedFirst Posted
Study publicly available on registry
January 4, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 9, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
October 9, 2008
CompletedMarch 5, 2020
March 1, 2020
2.3 years
December 21, 2007
March 2, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Change in endothelial progenitor cells colony forming units
Activity of endothelial progenitor cells will be assessed in participants following their procedures.
24 hours, 1 week, and 1 month after the procedure
Secondary Outcomes (1)
Change in clinical outcomes of coronary artery disease
Up to 5 years
Study Arms (2)
Angiography
Patients undergoing coronary angiography without percutaneous coronary angioplasty
Percutaneous Coronary Angioplasty
Patients with stable coronary artery disease undergoing angioplasty
Interventions
This is a procedure by which the blood vessels of the heart are imaged with an insertion of a catheter in the groin and blocked arteries are opened.
Eligibility Criteria
Patients with stable coronary artery disease
You may qualify if:
- Patients having stable coronary artery disease and undergoing either angiography or angioplasty
You may not qualify if:
- Unstable coronary artery disease associated with either EKG changes or elevation of cardiac enzymes
- Coronary intervention in the past 3 months
- Renal insufficiency
- Malignancy within the past 5 years except non-melanomatous skin cancers
- Recent infection within the past 3 months requiring antibiotic treatment
- Recent surgery requiring anesthesia within the past 3 months
- Having inflammatory disease
- Chemotherapy, radiation therapy or bone marrow stimulants at any time in the past
- Menstruating women
- Recent changes in statin, angiotensin-converting enzyme (ACE) inhibitors, or angiotensin receptor blocker doses
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Emory Universitylead
- American Federation for Aging Researchcollaborator
Study Sites (2)
Atlanta VA Medical Center
Atlanta, Georgia, 30033, United States
Emory University Hospital
Atlanta, Georgia, 30322, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Kreton Mavromatis, MD
Emory University
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
December 21, 2007
First Posted
January 4, 2008
Study Start
July 1, 2006
Primary Completion
October 9, 2008
Study Completion
October 9, 2008
Last Updated
March 5, 2020
Record last verified: 2020-03
Data Sharing
- IPD Sharing
- Will not share