Evaluation of Esophageal and Gastric Acid Levels in Patients Presenting With Upper Gastrointestinal Symptoms Using a Novel PH System
Sponsor study identifier
observational
85
1 country
1
Study Start
May 2004
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
October 2009
Actual (reported)Study Completion
October 2009
Actual (reported)The purpose of this research is to study the level of acid exposure above the gastroesophageal junction and the distal esophagus in patients with reflux symptoms using a capsule type acid measurement system. Patients with reflux symptoms are likely to have more acid reflux just above the junction of the stomach and the esophagus that may help to improve the diagnosis of gastroesophageal reflux disease (GERD). This may help better treat the reflux symptoms.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 2009
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 2004
Date type not reportedThis date has not been verified as actual or estimated.
December 21, 2007
Actual (reported)December 24, 2007
Actual (reported)October 2009
Actual (reported)October 2009
Actual (reported)This pilot project will attempt to study the level of acid exposure in the distal esophagus and proximal stomach of patients and correlate it with their symptoms.
24 hour period
To note patient satisfaction and comfort during the pH monitoring process.
7 days
Patients with Barrett's Esophagus
Patients with reflux symptoms but no Barrett's Esophagus
Patients without reflux symptoms and a normal endoscopy
The subjects in this study were selected from veterans ages 18 and above presenting for an upper endoscopy
Department of Veterans Affairs Medical Center
Kansas City, Missouri, 64128, United States
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Locke GR 3rd, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ 3rd. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology. 1997 May;112(5):1448-56. doi: 10.1016/s0016-5085(97)70025-8.
Prateek Sharma, MD
Department of Veterans Affairs Medical Center of Kansas City
85 participants (actual enrollment reported by the registry).
First Submitted
December 21, 2007
First Posted
December 24, 2007
Study Start
May 2004
Date type not reportedThis date has not been verified as actual or estimated.
Bone Physiology & Mechanics in Osteomyoplasty Amputation Rehabilitation
Contact the study team to confirm eligibility.
Agreus L. Natural history of dyspepsia. Gut. 2002 May;50 Suppl 4(Suppl 4):iv2-9. doi: 10.1136/gut.50.suppl_4.iv2.
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Samsom M, Verhagen MA, vanBerge Henegouwen GP, Smout AJ. Abnormal clearance of exogenous acid and increased acid sensitivity of the proximal duodenum in dyspeptic patients. Gastroenterology. 1999 Mar;116(3):515-20. doi: 10.1016/s0016-5085(99)70171-x.
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Talley NJ, Lauritsen K. The potential role of acid suppression in functional dyspepsia: the BOND, OPERA, PILOT, and ENCORE studies. Gut. 2002 May;50 Suppl 4(Suppl 4):iv36-41. doi: 10.1136/gut.50.suppl_4.iv36.
Veldhuyzen van Zanten SJ, Cleary C, Talley NJ, Peterson TC, Nyren O, Bradley LA, Verlinden M, Tytgat GN. Drug treatment of functional dyspepsia: a systematic analysis of trial methodology with recommendations for design of future trials. Am J Gastroenterol. 1996 Apr;91(4):660-73.
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23. Carlsson R, Bolling E, Jerndal , et al. Factors predicting response to omeprazole treatment in patients with functional dyspepsia. Gastroenterology 1996;110:A76.
Primary Completion
October 2009
Actual (reported)Study Completion
October 2009
Actual (reported)Last Updated
March 22, 2011
Record last verified: 2011-03
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