Testosterone in Castration-Resistant Prostate Cancer

NCT00577980 | Withdrawn Phase 2

• 1 other identifier: 2006-0316
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

Primary Objective: 1\. To assess the prostate-specific antigen (PSA)-response (50% decline) to Testosterone Replacement Therapy (TRT) in men with "intermediate and good-risk" Castration-Resistant Prostate Cancer (CRPC). Secondary Objectives:

1. 1.To assess the objective response and time-to-progression with TRT in CRPC.
2. 2.To assess serial changes in quality of life with TRT in these CRPC subsets.
3. 3.Translational: To study kinetics of circulating tumor cells with TRT and molecular correlates of response to TRT in CRPC.

Conditions

Prostate Cancer

Keywords

Prostate Cancer; Castration-Resistant Prostate Cancer; Testosterone Replacement Therapy; Testosterone; CRPC; TRT

Outcome Measures

Primary Outcomes (1)

• Rate of Prostate Specific Antigen (PSA) - decline by 50%

  Rate is the number of participants with PSA-response defined as PSA \> or equal to 50%-decline in PSA from baseline value sustained for at least 4 weeks with be no evidence of progressive disease.

  Every 2 weeks, after Week 8 every 4 weeks till end of study

Study Arms (1)

Testosterone

EXPERIMENTAL

Testosterone 200 mg administered parenterally by intramuscular (IM) injection every 2 weeks

Drug: Testosterone

Interventions

Testosterone DRUG

Initial dose of Testosterone 200 mg IM administered followed by 200 mg - 400 mg every 2 weeks.

Testosterone

Eligibility Criteria

• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients must have a history of histologically or cytologically confirmed adenocarcinoma of the prostate.
• Patients must have had a history of a response to medical or surgical castration therapy for prostate cancer with a serum PSA nadir of \</= 0.2 ng/ml and must not have had any known subsequent rise in serum PSA level of any magnitude above this nadir within the first 24 months of hormonal therapy. Nadir PSA value following hormonal therapy in combination with non-hormonal therapy such as radical prostatectomy, radiation therapy or chemotherapy do not count towards eligibility.
• Patients must have current evidence of progressive castration-resistant disease that is asymptomatic. Progressive disease is defined by a) radiological evidence of progression: any increase of \> 25% in the products of diameters or 30% in maximum diameter of any measurable lesion; or appearance of an unequivocally new lesion OR b) two consecutive rises in serum PSA of any magnitude measured at least 2 weeks apart, to a level above 2 ng/ml.
• Patients must have a minimum serum PSA level of 1 ng/ml.
• Patients may have palpable disease or radiological evidence of metastatic disease but without the following high-risk features: lymphangitic lung disease on chest X-ray or CT scan; bilateral hydronephrosis related to prostate cancer, palpable disease in the prostate, known brain metastases or suspicion of impending spinal cord or nerve root compression.
• Patients must have a documented castrate level of testosterone (\</= 50ng/ml). For patients who are medically castrated, luteinizing hormone releasing hormone analog will continue. The purpose is to simplify and harmonize exogenous testosterone therapeutics.
• Patients on anti-androgens should be discontinued from such therapy for at least 4 weeks (for bicalutamide for at least 6 weeks), prior to initiation of testosterone therapy and must have had documented progression of disease as in #3.
• Patients must satisfy the following laboratory criteria: serum total bilirubin \< 2 \* institutional upper limit of normal (ULN) and serum aspartate aminotransferase (AST or SGOT) and alanine aminotransferase (ALT or SGPT) \</= 2.5 \* institutional ULN.
• The Eastern Cooperative Oncology Group (ECOG) performance status 0-3.
• Ability to understand and the willingness to sign a written informed consent document.

You may not qualify if:

• Small cell or sarcomatoid prostate cancers are not eligible.
• No prior chemotherapy for CRPC.
• Patients may not be receiving any other investigational agents or hormonal therapy besides that specified in the study.
• Uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia.
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infections defined as requiring IV antibiotics on day 1 of treatment or psychiatric illness/social situations that would limit compliance with study requirements.
• Unwilling or unable because of comorbid conditions to tolerate intramuscular injections of testosterone every 2 weeks.
• Overt psychosis, mental disability or otherwise incompetent to give informed consent or history of non-compliance.

Sponsors & Collaborators

• M.D. Anderson Cancer Center: lead

Related Links

• UT MD Anderson Cancer Center website

MeSH Terms

Conditions

Prostatic Neoplasms

Interventions

Testosterone

Condition Hierarchy (Ancestors)

Genital Neoplasms, Male; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Prostatic Diseases; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Androstenols; Androstenes; Androstanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds; Testosterone Congeners; Gonadal Steroid Hormones; Gonadal Hormones; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists

Study Officials

• Paul Mathew, MD

  UT MD Anderson Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 17, 2007
• First Posted: December 20, 2007
• Study Start: December 1, 2007
• Primary Completion: June 1, 2008
• Study Completion: June 1, 2008
• Last Updated: April 29, 2013

Record last verified: 2013-04