Physiological Brain Atlas Development
Brain Atlas
5 other identifiers
observational
5,000
1 country
1
Brief Summary
The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume. This initially was used to improve DBS implants for Parkinson's Disease, Dystonia, Essential Tremor, and OCD, but now includes data acquired during all stereotactic brain procedures.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Aug 2006
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2006
CompletedFirst Submitted
Initial submission to the registry
December 13, 2007
CompletedFirst Posted
Study publicly available on registry
December 17, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
August 1, 2026
August 12, 2025
August 1, 2025
20 years
December 13, 2007
August 9, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
To create an atlas that will allow physiological information to be assigned to anatomical locations in MRI space, utilizing non-rigid MRI normalization algorithms.
The above data will specifically be acquired from the population of patients undergoing Stereotactic Brain Surgery
life of study
Secondary Outcomes (1)
To collate and analyze the physiological atlas in a statistical manner that allows doctors to understand and treat brain disease more precisely and based on population data.
life of study
Other Outcomes (2)
Assist surgical team intro-operatively
life of study
Improve post-implant programming of DBS unit
life of study
Study Arms (1)
Stereotactic Brain Procedures
Patients who have consented to undergo or have undergone a stereotactic brain procedure for any reason including those who need Deep Brain Stimulation, SEEG or other brain neurmodulation device implant.
Interventions
Eligibility Criteria
Patients who have already consented to having a stereotactic brain procedure for surgical treatment or implantation of a device to treat any brain disease. This includes patients who are undergoing normal neurosurgical care for the treatment of their movement disorder (like tremor and Parkinson's disease), epilepsy, pain, or psychiatric disease.
You may qualify if:
- All patients who are recommended for Stereotactic Brain procedures
- Any patient who has agreed to undergo a Stereotactic Brain procedure
- Patients age under 6 -90 years old
You may not qualify if:
- Patients who fail recommendation for Stereotactic Brain procedures
- Patients not consented for Stereotactic Brain procedures
- Patients outside the age range of 6 -90 years old
- Patients or legal guardians not able to provide informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Vanderbilt Univeristy
Nashville, Tennessee, 37232, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Darioq j Englot, MD, Ph.D.
Vanderbilt University, Dept. Neurosurgery
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor, Neurosurgery Department
Study Record Dates
First Submitted
December 13, 2007
First Posted
December 17, 2007
Study Start
August 1, 2006
Primary Completion (Estimated)
August 1, 2026
Study Completion (Estimated)
August 1, 2026
Last Updated
August 12, 2025
Record last verified: 2025-08