Aqueous Outflow Facility Changes With Posture
1 other identifier
observational
20
1 country
1
Brief Summary
Intraocular pressure (IOP) varies with body position, with a significant increase occurring from the seated to the supine position. Previous research has indicated that the IOP increase cannot be explained by changes in episcleral venous pressure(blood flow leading away from the eye) alone. As well, previous research has indicated that aqueous flow rate is independent of body position. The purpose of this project was to determine if aqueous humor outflow facility varied with changes in posture.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Oct 2007
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2007
CompletedFirst Submitted
Initial submission to the registry
December 7, 2007
CompletedFirst Posted
Study publicly available on registry
December 11, 2007
CompletedNovember 26, 2009
November 1, 2009
2 months
December 7, 2007
November 24, 2009
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Looking for change in outflow facility with change in position
4 minutes per position
Study Arms (1)
Only one group- A
Healthy young subjects aged 18-45.
Eligibility Criteria
Healthy young volunteers aged 18-45 will be recruited from Mayo Clinic employees and students, and local area residents.
You may qualify if:
- Healthy, aged 18-45.
- Subjects will be given a complete dilated eye exam and an updated medical history will be performed
You may not qualify if:
- IOP greater than 22mmHg
- Evidence of glaucomatous optic neuropathy
- Poor fixation
- Nystagmus
- Tropias
- Phorias
- Recent infection
- Corneal scarring preventing reliable tonometry
- Evidence of pigment dispersion
- Narrow angles
- History of trauma or surgery
- Systemic use of beta blockers or steroids
- Diabetic eye disease, uveitis, high (\>6D) myopia or high(\>4D) hyperopia.
- Patients with chronic medical conditions(eg: hypertension) will be allowed to participate as long as their medical condition has been under good control over the preceding 12 months.
- Subjects will also need to have good cervical neck malleability and be able to meet the physical needs of the protocol which call for 4 minutes of neck extension.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Mayo Cliniclead
Study Sites (1)
Mayo Clinic
Rochester, Minnesota, 55902, United States
Related Publications (1)
GALIN MA, McIVOR JW, MAGRUDER GB. Influence of position on intraocular pressure. Am J Ophthalmol. 1963 Apr;55:720-3. No abstract available.
PMID: 13960329BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Deepan Selvadurai, MD
Mayo Clinic
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
December 7, 2007
First Posted
December 11, 2007
Study Start
October 1, 2007
Primary Completion
December 1, 2007
Study Completion
December 1, 2007
Last Updated
November 26, 2009
Record last verified: 2009-11