A Combined Psycho-pharmacological and Brain Imaging Study of Human Sexuality

NCT00569413 | Suspended DMC

• 2 other identifiers: 281207HMO-CTILFirst 978[1].07
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

The current study combines a molecular genetic perspective, self report and brain imaging to the study of human sexuality in control subjects and individuals from a sexual disorder clinic. The investigators hypothesize that the variability in components of the brain dopaminergic system expressed in the mesolimbic reward system can explain variability in human sexuality, especially in desire and pleasure associated with sex.

Conditions

Hypoactive Sexual Desire Disorder; Erectile Dysfunction

Keywords

Sex; brain imaging; dopamine; sexual disorder

Outcome Measures

Primary Outcomes (1)

• Brain Imaging data of DRD2 receptor occupancy during watching a sex videotape and neutral videotape

  2 Brain imaging sessions a week apart

Secondary Outcomes (1)

• Questionnaire ratings of human sexuality, pleasure, and anticipatory reward

  Taken during brain scans

Study Arms (2)

1

Healthy control subjects (n=20) age 21-65 who do not suffer from a psychiatric diagnosis or neurological damage, are under age, or are pregnant women

2

20 patients who suffer from sexual disorder (reduced sexual desire or sexual function) from a sexual disorder clinic, age 21-65, without any other psychiatric disorder, neurological damage, are not under age or pregnant women.

Eligibility Criteria

• Age: 21 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A group of healthy volunteers from the general public. A group of patients who suffer from sexual disorder from a primary care clinic.

You may qualify if:

• Healthy volunteers and patients
• Age 21-65
• Male or female

You may not qualify if:

• Psychiatric diagnosis/psychosis
• Neurological damage associated with loss of consciousness
• Infectious disease HIV
• Herpes
• Syphilis
• Hyperactivity treated with ritalin
• Pregnant women
• Under age

Sponsors & Collaborators

• Hadassah Medical Organization: lead
• Ben-Gurion University of the Negev: collaborator

MeSH Terms

Conditions

Sexual Dysfunctions, Psychological; Erectile Dysfunction; Coitus; Sexual Dysfunction, Physiological

Condition Hierarchy (Ancestors)

Mental Disorders; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Male Urogenital Diseases; Sexual Behavior; Behavior

Study Officials

• Aviv M Weinstein, Ph.D

  Hadasah Medical Organization, Jerusalem Israel

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 6, 2007
• First Posted: December 7, 2007
• Study Start: April 1, 2011
• Primary Completion: October 1, 2011
• Study Completion: October 1, 2011
• Last Updated: June 10, 2010

Record last verified: 2010-06