NCT00569361

Brief Summary

Using a human pangenomic microarray, the researchers established expression profiles of nasal epithelial cells, collected by brushing of patients belonging to one of four distinct groups:

  1. 1.allergic rhinitis to dust mite (AR) isolated (n=12),
  2. 2.AR associated with bronchial hyperreactivity (n=12),
  3. 3.AR associated with asthma (n=14),
  4. 4.control (n=14).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Nov 2004

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2004

Completed
11 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2005

Completed
2.2 years until next milestone

First Submitted

Initial submission to the registry

December 6, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

December 7, 2007

Completed
Last Updated

June 9, 2009

Status Verified

June 1, 2009

First QC Date

December 6, 2007

Last Update Submit

June 8, 2009

Conditions

Allergic Rhinitis

Keywords

allergic rhinitis to dust miteallergic rhinitis associated with bronchial hyperreactivityallergic rhinitis associated with asthma

Outcome Measures

Primary Outcomes (1)

  • Transcriptome analysis: genes statistically modulated between groups, predictive biomarkers allowing correct classification of groups

    At the sample time

Secondary Outcomes (1)

  • Validation with other techniques: Q-PCR

    At the sample time

Study Arms (1)

A

OTHER

Collection of nasal epithelial cells by brushing

Procedure: Collection of nasal epithelial cells

Interventions

Collection of nasal epithelial cellsPROCEDURE

Collection of nasal epithelial cells by brushing

A

Eligibility Criteria

Age6 Years - 17 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Patients:
  • Patients between 6 and 17 years old
  • Patients with allergic rhinitis
  • Witness:
  • Patients between 6 and 17 years old
  • Patients without allergic rhinitis and asthma

You may not qualify if:

  • Rhino-bronchitis infection dated from less than 15 days
  • Patients younger than 6 or older than 17 years

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Pediatrics, Nice University Hospital

Nice, 06000, France

Location

Related Publications (1)

  • Giovannini-Chami L, Marcet B, Moreilhon C, Chevalier B, Illie MI, Lebrigand K, Robbe-Sermesant K, Bourrier T, Michiels JF, Mari B, Crenesse D, Hofman P, de Blic J, Castillo L, Albertini M, Barbry P. Distinct epithelial gene expression phenotypes in childhood respiratory allergy. Eur Respir J. 2012 May;39(5):1197-205. doi: 10.1183/09031936.00070511. Epub 2011 Oct 17.

    PMID: 22005912DERIVED

MeSH Terms

Conditions

Rhinitis, Allergic

Condition Hierarchy (Ancestors)

RhinitisNose DiseasesRespiratory Tract DiseasesRespiratory HypersensitivityOtorhinolaryngologic DiseasesHypersensitivity, ImmediateHypersensitivityImmune System Diseases

Study Officials

  • Marc Albertini, Professor

    Department of Pediatrics of Nice University Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
SCREENING
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER

Study Record Dates

First Submitted

December 6, 2007

First Posted

December 7, 2007

Study Start

November 1, 2004

Study Completion

October 1, 2005

Last Updated

June 9, 2009

Record last verified: 2009-06

Locations

FR(1)