Tiotropium Once Daily 18 Mcg Versus Salmeterol Twice Daily 50 Mcg on Time to First Exacerbation in COPD Patients.

NCT00563381 | Completed Phase 4 Results

• 2 other identifiers: 205.389EUDRACT2007-001840-33
• Study Type: interventional
• Target: 7,376
• Locations: 24 countries
• Sites: 746

Brief Summary

This is a randomised, double-blind, double-dummy, multinational, multicentre, parallel group trial comparing tiotropium (18 mcg) inhalation capsule via HandiHaler and salmeterol (50 mcg) via MDI in patients with COPD. There will be a two-week run-in period followed by a 52-week randomised treatment phase. Patients who withdraw prematurely from trial medication will be encouraged to remain in the trial and participate in follow-up telephone contacts until their predicted normal exit date from the trial (i.e. 52 weeks after taking the first dose of randomised treatment). The phone calls will be made at all scheduled visits. The primary objective of this study is to compare the effect of tiotropium (18 mcg) inhalation capsule via HandiHaler with that of salmeterol (50 mcg) via MDI on COPD exacerbations. The primary endpoint is time to first COPD exacerbation during the 52 week randomised treatment period. A COPD exacerbation will be defined as a complex of respiratory events / symptoms (increase or new onset) of more than one of the following: cough, sputum, wheezing, dyspnoea or chest tightness with at least one symptom lasting at least three days requiring treatment with antibiotics and/or systemic steroids and/or hospitalisation. The onset of an exacerbation is defined as the onset of the first new or increased reported symptom. The end of the exacerbation should be recorded as defined by the investigator. Only COPD exacerbations with onset during randomised treatment will be included in the analysis.

Conditions

Pulmonary Disease, Chronic Obstructive

Outcome Measures

Primary Outcomes (1)

• First Occurrence of (Moderate or Severe) COPD Exacerbation

  First occurrence analysed by Cox regression as time to first exacerbation and reported as hazard ratio. An exacerbation was defined as an increase or new onset of more than 1 symptom (cough, sputum, wheezing, dyspnoea, chest tightness), with at least 1 symptom lasting at least 3 days and requiring treatment with systemic steroids and/or antibiotics (moderate exacerbation) or hospitalisation (severe exacerbation).

  52 weeks

Secondary Outcomes (30)

• COPD Exacerbations Per Patient-year Leading to Hospitalisation

  52 weeks

• Number of Participants With at Least One COPD Exacerbation

  52 weeks

• COPD Exacerbations Per Patient-year

  52 weeks

• First Occurrence of COPD Exacerbation Leading to Hospitalization

  52 weeks

• Number of Participants With at Least One COPD Exacerbation Leading to Hospitalisation

  52 weeks

Study Arms (2)

Tiotropium + Placebo

ACTIVE COMPARATOR

patients inhale Tiotropium 18mcg once daily via HandiHaler and Placebo MDI twice daily

Drug: Tiotropium bromide; Drug: Placebo Salmeterol

Salmeterol + Placebo

ACTIVE COMPARATOR

patients inhale Salmeterol 50mcg twice daily via MDI and Placebo HandiHaler once daily

Drug: Salmeterol; Drug: Placebo Tiotropium

Interventions

Tiotropium bromide DRUG

18 mcg/daily

Tiotropium + Placebo

Salmeterol DRUG

100 mcg/daily

Salmeterol + Placebo

Placebo Salmeterol DRUG

Placebo identical to Salmeterol device

Tiotropium + Placebo

Placebo Tiotropium DRUG

Placebo identical to Tiotropium device

Salmeterol + Placebo

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All patients must have a diagnosis of chronic obstructive pulmonary disease (COPD) and must meet the following criteria at Visit 1:
• Patients must have relatively stable, moderate to very severe airway obstruction with a post-bronchodilator FEV1 \<=70% of predicted normal and FEV1 \<=70% of FVC post-bronchodilator (i.e. 30 minutes after inhalation of 4 puffs of 100 µg salbutamol or equivalent SABA). Predicted normal values will be calculated according to ECSC.
• For Height measured in inches Males: FEV1 predicted (L) = 4.30 x (height (inches) / 39.37)-0.029 x age (yrs) - 2.49 Females:FEV1 predicted (L) = 3.95 x (height (inches) / 39.37)-0.025 x age (yrs) - 2.60 For Height measured in metres Males: FEV1 predicted (L) = 4.30 x (height (metres)) - 0.029 x age (years) - 2.49 Females: FEV1 predicted (L) = 3.95 x (height (metres)) - 0.025 x age (years) - 2.60
• All patients must sign an informed consent consistent with ICH-GCP guidelines prior to participation in the trial.
• Male or female patients 40 years of age or older.
• Patients with a history of at least one exacerbation within the past year requiring treatment with either antibiotics and/or systemic steroids and/or hospitalisation.
• Patients must be current or ex-smokers with a smoking history of \>= 10 pack-years. (Patients who have never smoked cigarettes must be excluded.)
• Patients must be able to perform all study-related procedures including technically acceptable pulmonary function tests (PFTs).
• Patients must be able to inhale medication in a competent manner from the HandiHaler and a metered dose inhaler (MDI).
• Patients must be able to maintain records (patient daily diary card) during the study period as required in the protocol.

You may not qualify if:

• Significant diseases other than COPD. A significant disease is defined as a disease or condition which, in the opinion of the investigator, may put the patient at risk because of participation in the study or may influence either the results of the study or the patients' ability to participate in the study.
• Patients with a diagnosis of asthma.
• Patients with a life-threatening pulmonary obstruction, or a history of cystic fibrosis.
• Patients with known active tuberculosis.
• Patients with a known symptomatic prostatic hyperplasia or bladder neck obstruction. Patients with symptomatically-controlled prostatic hyperplasia on medication may be included and should continue their medication.
• Patients with known narrow-angle glaucoma.
• Patients with a history of myocardial infarction within the year prior to Visit 1.
• Patients with a history of hospital admission for heart failure within the year prior to Visit 1.
• Patients with cardiac arrhythmia requiring medical or surgical treatment.
• Patients with severe cardiovascular disorders.
• Patients with a known hypersensitivity to anticholinergic drugs, beta-adrenergics, lactose or any other component of the medication delivery system.
• Patients with known moderate or severe renal insufficiency (known creatinine clearance of \<= 50 mL/min).
• Patients with untreated known hypokalaemia.
• Patients with untreated known thyrotoxicosis.
• Patients with brittle/unstable diabetes mellitus.

Sponsors & Collaborators

• Boehringer Ingelheim: lead
• Pfizer: collaborator

Study Sites (752)

205.389.1020 Boehringer Ingelheim Investigational Site

Feldbach, Austria

Location

205.389.1010 Boehringer Ingelheim Investigational Site

Feldkirch, Austria

Location

205.389.1003 Boehringer Ingelheim Investigational Site

Gänserndorf, Austria

Location

205.389.1011 Boehringer Ingelheim Investigational Site

Grimmenstein/Hochegg, Austria

Location

205.389.1005 Boehringer Ingelheim Investigational Site

Hallein, Austria

Location

205.389.1023 Boehringer Ingelheim Investigational Site

Linz, Austria

Location

205.389.1001 Boehringer Ingelheim Investigational Site

Mittersill, Austria

Location

205.389.1027 Boehringer Ingelheim Investigational Site

Salzburg, Austria

Location

205.389.1026 Boehringer Ingelheim Investigational Site

Schlüsslberg, Austria

Location

205.389.1016 Boehringer Ingelheim Investigational Site

Spittal/Drau, Austria

Location

205.389.1022 Boehringer Ingelheim Investigational Site

Steyr, Austria

Location

205.389.1002 Boehringer Ingelheim Investigational Site

Vienna, Austria

Location

205.389.1006 Boehringer Ingelheim Investigational Site

Vienna, Austria

Location

205.389.1014 Boehringer Ingelheim Investigational Site

Vienna, Austria

Location

205.389.1018 Boehringer Ingelheim Investigational Site

Vienna, Austria

Location

205.389.1021 Boehringer Ingelheim Investigational Site

Vienna, Austria

Location

205.389.1029 Boehringer Ingelheim Investigational Site

Vienna, Austria

Location

205.389.1017 Boehringer Ingelheim Investigational Site

Zwettl Stadt, Austria

Location

205.389.1120 Boehringer Ingelheim Investigational Site

Buizingen, Belgium

Location

205.389.1124 Boehringer Ingelheim Investigational Site

Cerexhe-Heuseux, Belgium

Location

205.389.1116 Boehringer Ingelheim Investigational Site

Chenée (Liége), Belgium

Location

205.389.1121 Boehringer Ingelheim Investigational Site

Dour, Belgium

Location

205.389.1113 Boehringer Ingelheim Investigational Site

Gembloux, Belgium

Location

205.389.1117 Boehringer Ingelheim Investigational Site

Gozée, Belgium

Location

205.389.1126 Boehringer Ingelheim Investigational Site

Hasselt, Belgium

Location

205.389.1129 Boehringer Ingelheim Investigational Site

Natoye, Belgium

Location

205.389.1130 Boehringer Ingelheim Investigational Site

Quaregnon, Belgium

Location

205.389.1115 Boehringer Ingelheim Investigational Site

Thuillies, Belgium

Location

205.389.1107 Boehringer Ingelheim Investigational Site

Wetteren, Belgium

Location

205.389.3911 Boehringer Ingelheim Investigational Site

Pazardzhik, Bulgaria

Location

205.389.3903 Boehringer Ingelheim Investigational Site

Plovdiv, Bulgaria

Location

205.389.3915 Boehringer Ingelheim Investigational Site

Plovdiv, Bulgaria

Location

205.389.3918 Boehringer Ingelheim Investigational Site

Rousse, Bulgaria

Location

205.389.3914 Boehringer Ingelheim Investigational Site

Sliven, Bulgaria

Location

205.389.3902 Boehringer Ingelheim Investigational Site

Sofia, Bulgaria

Location

205.389.3906 Boehringer Ingelheim Investigational Site

Sofia, Bulgaria

Location

205.389.3907 Boehringer Ingelheim Investigational Site

Sofia, Bulgaria

Location

205.389.3908 Boehringer Ingelheim Investigational Site

Stara Zagora, Bulgaria

Location

205.389.3916 Boehringer Ingelheim Investigational Site

Troyan Municipality, Bulgaria

Location

205.389.3912 Boehringer Ingelheim Investigational Site

Varna, Bulgaria

Location

205.389.3901 Boehringer Ingelheim Investigational Site

Veliko Tarnovo, Bulgaria

Location

205.389.1211 Boehringer Ingelheim Investigational Site

Benešov, Czechia

Location

205.389.1213 Boehringer Ingelheim Investigational Site

Beroun, Czechia

Location

205.389.1220 Boehringer Ingelheim Investigational Site

Beroun, Czechia

Location

205.389.1204 Boehringer Ingelheim Investigational Site

Brno-Královo Pole, Czechia

Location

205.389.1212 Boehringer Ingelheim Investigational Site

Cheb, Czechia

Location

205.389.1205 Boehringer Ingelheim Investigational Site

Havlíčkův Brod, Czechia

Location

205.389.1230 Boehringer Ingelheim Investigational Site

Humpolec, Czechia

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205.389.1208 Boehringer Ingelheim Investigational Site

Jaroměř, Czechia

Location

205.389.1219 Boehringer Ingelheim Investigational Site

Kyjov, Czechia

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205.389.1225 Boehringer Ingelheim Investigational Site

Liberec, Czechia

Location

205.389.1218 Boehringer Ingelheim Investigational Site

Litoměřice, Czechia

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205.389.1214 Boehringer Ingelheim Investigational Site

Lovosice, Czechia

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205.389.1207 Boehringer Ingelheim Investigational Site

Neratovice, Czechia

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205.389.1222 Boehringer Ingelheim Investigational Site

Ostrava, Czechia

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205.389.1209 Boehringer Ingelheim Investigational Site

Pilsen, Czechia

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205.389.1216 Boehringer Ingelheim Investigational Site

Pilsen, Czechia

Location

205.389.1215 Boehringer Ingelheim Investigational Site

Prague, Czechia

Location

205.389.1217 Boehringer Ingelheim Investigational Site

Prague, Czechia

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205.389.1223 Boehringer Ingelheim Investigational Site

Prague, Czechia

Location

205.389.1227 Boehringer Ingelheim Investigational Site

Prague, Czechia

Location

205.389.1229 Boehringer Ingelheim Investigational Site

Prague, Czechia

Location

205.389.1232 Boehringer Ingelheim Investigational Site

Prague, Czechia

Location

205.389.1224 Boehringer Ingelheim Investigational Site

Praha 6 - Brevnov, Czechia

Location

205.389.1228 Boehringer Ingelheim Investigational Site

Přerov, Czechia

Location

205.389.1231 Boehringer Ingelheim Investigational Site

Rokycany, Czechia

Location

205.389.1221 Boehringer Ingelheim Investigational Site

Strakonice, Czechia

Location

205.389.1206 Boehringer Ingelheim Investigational Site

Třemošná, Czechia

Location

205.389.1210 Boehringer Ingelheim Investigational Site

Znojmo, Czechia

Location

205.389.1201 Boehringer Ingelheim Investigational Site

Žatec, Czechia

Location

205.389.1304 Boehringer Ingelheim Investigational Site

Copenhagen, Denmark

Location

205.389.1301 Boehringer Ingelheim Investigational Site

Elsinore, Denmark

Location

205.389.1308 Boehringer Ingelheim Investigational Site

Elsinore, Denmark

Location

205.389.1309 Boehringer Ingelheim Investigational Site

Frederikssund, Denmark

Location

205.389.1311 Boehringer Ingelheim Investigational Site

Holstebro, Denmark

Location

205.389.1302 Boehringer Ingelheim Investigational Site

Næstved, Denmark

Location

205.389.1303 Boehringer Ingelheim Investigational Site

Roskilde, Denmark

Location

205.389.1310 Boehringer Ingelheim Investigational Site

Skive, Denmark

Location

205.389.1312 Boehringer Ingelheim Investigational Site

Sønderborg, Denmark

Location

205.389.1307 Boehringer Ingelheim Investigational Site

Værløse, Denmark

Location

205.389.1402 Boehringer Ingelheim Investigational Site

Helsinki, Finland

Location

205.389.1416 Boehringer Ingelheim Investigational Site

Hyvinkää, Finland

Location

205.389.1410 Boehringer Ingelheim Investigational Site

Jyväskylä, Finland

Location

205.389.1404 Boehringer Ingelheim Investigational Site

Lahti, Finland

Location

205.389.1417 Boehringer Ingelheim Investigational Site

Lappeenranta, Finland

Location

205.389.1415 Boehringer Ingelheim Investigational Site

Lohja, Finland

Location

205.389.1411 Boehringer Ingelheim Investigational Site

Mikkeli, Finland

Location

205.389.1409 Boehringer Ingelheim Investigational Site

Pori, Finland

Location

205.389.1412 Boehringer Ingelheim Investigational Site

Preitilä Paimio, Finland

Location

205.389.1407 Boehringer Ingelheim Investigational Site

Turku, Finland

Location

205.389.1607 Boehringer Ingelheim Investigational Site

Baugé, France

Location

205.389.1525 Boehringer Ingelheim Investigational Site

Beauvais, France

Location

205.389.1523 Boehringer Ingelheim Investigational Site

Béthune, France

Location

205.389.1571 Boehringer Ingelheim Investigational Site

Cestas, France

Location

205.389.1561 Boehringer Ingelheim Investigational Site

Charry Le Rouet, France

Location

205.389.1507 Boehringer Ingelheim Investigational Site

Cholet, France

Location

205.389.1554 Boehringer Ingelheim Investigational Site

Ermont, France

Location

205.389.1606 Boehringer Ingelheim Investigational Site

Écouflant, France

Location

205.389.1597 Boehringer Ingelheim Investigational Site

La Barre-de-Monts, France

Location

205.389.1581 Boehringer Ingelheim Investigational Site

La Jubaudière, France

Location

205.389.1536 Boehringer Ingelheim Investigational Site

La Roche-sur-Yon, France

Location

205.389.1598 Boehringer Ingelheim Investigational Site

La Roche-sur-Yon, France

Location

205.389.1501 Boehringer Ingelheim Investigational Site

Le Kremlin-Bicêtre, France

Location

205.389.1503 Boehringer Ingelheim Investigational Site

Le Mans, France

Location

205.389.1586 Boehringer Ingelheim Investigational Site

Le Pradet, France

Location

205.389.1528 Boehringer Ingelheim Investigational Site

Marseille, France

Location

205.389.1530 Boehringer Ingelheim Investigational Site

Marseille, France

Location

205.389.1558 Boehringer Ingelheim Investigational Site

Marseille, France

Location

205.389.1564 Boehringer Ingelheim Investigational Site

Marseille, France

Location

205.389.1565 Boehringer Ingelheim Investigational Site

Marseille, France

Location

205.389.1539 Boehringer Ingelheim Investigational Site

Montfermeil, France

Location

205.389.1608 Boehringer Ingelheim Investigational Site

Nantes, France

Location

205.389.1526 Boehringer Ingelheim Investigational Site

Nice, France

Location

205.389.1504 Boehringer Ingelheim Investigational Site

Nîmes, France

Location

205.389.1502 Boehringer Ingelheim Investigational Site

Ollioules, France

Location

205.389.1541 Boehringer Ingelheim Investigational Site

Orléans, France

Location

205.389.1527 Boehringer Ingelheim Investigational Site

Perpignan, France

Location

205.389.1532 Boehringer Ingelheim Investigational Site

Pierre Benite Cédex, France

Location

205.389.1553 Boehringer Ingelheim Investigational Site

Rennes, France

Location

205.389.1567 Boehringer Ingelheim Investigational Site

Saint Orens de Cameville, France

Location

205.389.1555 Boehringer Ingelheim Investigational Site

Saint-Dié, France

Location

205.389.1514 Boehringer Ingelheim Investigational Site

Saint-Etienne, France

Location

205.389.1575 Boehringer Ingelheim Investigational Site

Saint-Germain-du-Puch, France

Location

205.389.1572 Boehringer Ingelheim Investigational Site

Saint-Laurent, France

Location

205.389.1547 Boehringer Ingelheim Investigational Site

Saint-Laurent-du-Var, France

Location

205.389.1577 Boehringer Ingelheim Investigational Site

Saint-Pierre-Montlimart, France

Location

205.389.1531 Boehringer Ingelheim Investigational Site

Saint-Quentin, France

Location

205.389.1569 Boehringer Ingelheim Investigational Site

Seysses, France

Location

205.389.1520 Boehringer Ingelheim Investigational Site

Sélestat, France

Location

205.389.1510 Boehringer Ingelheim Investigational Site

Strasbourg, France

Location

205.389.1522 Boehringer Ingelheim Investigational Site

Strasbourg, France

Location

205.389.1512 Boehringer Ingelheim Investigational Site

Toulon, France

Location

205.389.1515 Boehringer Ingelheim Investigational Site

Toulon, France

Location

205.389.1519 Boehringer Ingelheim Investigational Site

Toulon, France

Location

205.389.1588 Boehringer Ingelheim Investigational Site

Toulon, France

Location

205.389.1589 Boehringer Ingelheim Investigational Site

Toulon, France

Location

205.389.1590 Boehringer Ingelheim Investigational Site

Toulon, France

Location

205.389.1595 Boehringer Ingelheim Investigational Site

Toulon, France

Location

205.389.1542 Boehringer Ingelheim Investigational Site

Toulouse, France

Location

205.389.1574 Boehringer Ingelheim Investigational Site

Villenave-d'Ornon, France

Location

205.389.1741 Boehringer Ingelheim Investigational Site

Aachen, Germany

Location

205.389.1857 Boehringer Ingelheim Investigational Site

Aalen, Germany

Location

205.389.1934 Boehringer Ingelheim Investigational Site

Auerbach, Germany

Location

205.389.1868 Boehringer Ingelheim Investigational Site

Augsburg, Germany

Location

205.389.1887 Boehringer Ingelheim Investigational Site

Augsburg, Germany

Location

205.389.1707 Boehringer Ingelheim Investigational Site

Bad Lippspringe, Germany

Location

205.389.1722 Boehringer Ingelheim Investigational Site

Bad Pymont, Germany

Location

205.389.1850 Boehringer Ingelheim Investigational Site

Bad Wörishofen, Germany

Location

205.389.1765 Boehringer Ingelheim Investigational Site

Bahrdorf, Germany

Location

205.389.1792 Boehringer Ingelheim Investigational Site

Beckum, Germany

Location

205.389.1801 Boehringer Ingelheim Investigational Site

Bensheim, Germany

Location

205.389.1946 Boehringer Ingelheim Investigational Site

Bensheim, Germany

Location

205.389.1824 Boehringer Ingelheim Investigational Site

Bergisch Gladbach, Germany

Location

205.389.1709 Boehringer Ingelheim Investigational Site

Bergkamen, Germany

Location

205.389.1750 Boehringer Ingelheim Investigational Site

Berkatal-Frankershausen, Germany

Location

205.389.1701 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1743 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1769 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1789 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1790 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1847 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1855 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1861 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1862 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1867 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1903 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1931 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1932 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1937 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1960 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1969 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1981 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1983 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1984 Boehringer Ingelheim Investigational Site

Berlin, Germany

Location

205.389.1747 Boehringer Ingelheim Investigational Site

Bocholt, Germany

Location

205.389.1808 Boehringer Ingelheim Investigational Site

Bochum, Germany

Location

205.389.1811 Boehringer Ingelheim Investigational Site

Bochum, Germany

Location

205.389.1828 Boehringer Ingelheim Investigational Site

Bonn, Germany

Location

205.389.1870 Boehringer Ingelheim Investigational Site

Bonn, Germany

Location

205.389.1705 Boehringer Ingelheim Investigational Site

Borna, Germany

Location

205.389.1809 Boehringer Ingelheim Investigational Site

Brandenburg/Havel, Germany

Location

205.389.1859 Boehringer Ingelheim Investigational Site

Bruchsal, Germany

Location

205.389.1734 Boehringer Ingelheim Investigational Site

Camburg, Germany

Location

205.389.1923 Boehringer Ingelheim Investigational Site

Celle, Germany

Location

205.389.1892 Boehringer Ingelheim Investigational Site

Cologne, Germany

Location

205.389.1974 Boehringer Ingelheim Investigational Site

Cologne, Germany

Location

205.389.1901 Boehringer Ingelheim Investigational Site

Coswig, Germany

Location

205.389.1891 Boehringer Ingelheim Investigational Site

Cottbus, Germany

Location

205.389.1858 Boehringer Ingelheim Investigational Site

Deggendorf, Germany

Location

205.389.1784 Boehringer Ingelheim Investigational Site

Donaueschingen, Germany

Location

205.389.1713 Boehringer Ingelheim Investigational Site

Dortmund, Germany

Location

205.389.1706 Boehringer Ingelheim Investigational Site

Dresden, Germany

Location

205.389.1967 Boehringer Ingelheim Investigational Site

Düren, Germany

Location

205.389.1814 Boehringer Ingelheim Investigational Site

Engelskirchen, Germany

Location

205.389.1773 Boehringer Ingelheim Investigational Site

Ense, Germany

Location

205.389.1727 Boehringer Ingelheim Investigational Site

Eppelborn-Bubach, Germany

Location

205.389.1864 Boehringer Ingelheim Investigational Site

Erfurt, Germany

Location

205.389.1940 Boehringer Ingelheim Investigational Site

Erlangen, Germany

Location

205.389.1900 Boehringer Ingelheim Investigational Site

Eschwege, Germany

Location

205.389.1758 Boehringer Ingelheim Investigational Site

Essen, Germany

Location

205.389.1975 Boehringer Ingelheim Investigational Site

Essen, Germany

Location

205.389.1982 Boehringer Ingelheim Investigational Site

Essen, Germany

Location

205.389.1724 Boehringer Ingelheim Investigational Site

Ettlingen, Germany

Location

205.389.1806 Boehringer Ingelheim Investigational Site

Feldkirchen-Westerham, Germany

Location

205.389.1976 Boehringer Ingelheim Investigational Site

Forchheim, Germany

Location

205.389.1943 Boehringer Ingelheim Investigational Site

Föhren, Germany

Location

205.389.1795 Boehringer Ingelheim Investigational Site

Frankenberg, Germany

Location

205.389.1905 Boehringer Ingelheim Investigational Site

Frankfurt am Main, Germany

Location

205.389.1752 Boehringer Ingelheim Investigational Site

Fuldatal-Ihringshausen, Germany

Location

205.389.1971 Boehringer Ingelheim Investigational Site

Fürth, Germany

Location

205.389.1766 Boehringer Ingelheim Investigational Site

Gars, Germany

Location

205.389.1977 Boehringer Ingelheim Investigational Site

Gelsenkirchen, Germany

Location

205.389.1744 Boehringer Ingelheim Investigational Site

Georgensgmünd, Germany

Location

205.389.1875 Boehringer Ingelheim Investigational Site

Giessen, Germany

Location

205.389.1836 Boehringer Ingelheim Investigational Site

Gifhorn, Germany

Location

205.389.1914 Boehringer Ingelheim Investigational Site

Goch, Germany

Location

205.389.1751 Boehringer Ingelheim Investigational Site

Göttingen, Germany

Location

205.389.1886 Boehringer Ingelheim Investigational Site

Greiz, Germany

Location

205.389.1768 Boehringer Ingelheim Investigational Site

Grünberg, Germany

Location

205.389.1831 Boehringer Ingelheim Investigational Site

Hagen, Germany

Location

205.389.1827 Boehringer Ingelheim Investigational Site

Halle, Germany

Location

205.389.1917 Boehringer Ingelheim Investigational Site

Hamburg, Germany

Location

205.389.1924 Boehringer Ingelheim Investigational Site

Hamburg, Germany

Location

205.389.1925 Boehringer Ingelheim Investigational Site

Hamburg, Germany

Location

205.389.1980 Boehringer Ingelheim Investigational Site

Hamburg, Germany

Location

205.389.1716 Boehringer Ingelheim Investigational Site

Hammah, Germany

Location

205.389.1702 Boehringer Ingelheim Investigational Site

Hammelburg, Germany

Location

205.389.1802 Boehringer Ingelheim Investigational Site

Hanover, Germany

Location

205.389.1712 Boehringer Ingelheim Investigational Site

Harsewinkel, Germany

Location

205.389.1738 Boehringer Ingelheim Investigational Site

Hauzenberg, Germany

Location

205.389.1860 Boehringer Ingelheim Investigational Site

Hemmingen, Germany

Location

205.389.1949 Boehringer Ingelheim Investigational Site

Höchstädt, Germany

Location

205.389.1726 Boehringer Ingelheim Investigational Site

Ingelheim, Germany

Location

205.389.1873 Boehringer Ingelheim Investigational Site

Karlsruhe, Germany

Location

205.389.1838 Boehringer Ingelheim Investigational Site

Kaufbeuren, Germany

Location

205.389.1704 Boehringer Ingelheim Investigational Site

Käbschütztal-Krögis, Germany

Location

205.389.1839 Boehringer Ingelheim Investigational Site

Koblenz, Germany

Location

205.389.1813 Boehringer Ingelheim Investigational Site

Köthen, Germany

Location

205.389.1881 Boehringer Ingelheim Investigational Site

Krefeld, Germany

Location

205.389.1786 Boehringer Ingelheim Investigational Site

Krumpa, Germany

Location

205.389.1902 Boehringer Ingelheim Investigational Site

Landsberg, Germany

Location

205.389.1837 Boehringer Ingelheim Investigational Site

Leipzig, Germany

Location

205.389.1841 Boehringer Ingelheim Investigational Site

Leipzig, Germany

Location

205.389.1894 Boehringer Ingelheim Investigational Site

Leipzig, Germany

Location

205.389.1908 Boehringer Ingelheim Investigational Site

Leipzig, Germany

Location

205.389.1874 Boehringer Ingelheim Investigational Site

Leonberg, Germany

Location

205.389.1955 Boehringer Ingelheim Investigational Site

Limburg, Germany

Location

205.389.1904 Boehringer Ingelheim Investigational Site

Lorch, Germany

Location

205.389.1877 Boehringer Ingelheim Investigational Site

Lübeck, Germany

Location

205.389.1823 Boehringer Ingelheim Investigational Site

Lützen, Germany

Location

205.389.1879 Boehringer Ingelheim Investigational Site

Magdeburg, Germany

Location

205.389.1840 Boehringer Ingelheim Investigational Site

Mannheim, Germany

Location

205.389.1978 Boehringer Ingelheim Investigational Site

Mannheim, Germany

Location

205.389.1866 Boehringer Ingelheim Investigational Site

Marburg, Germany

Location

205.389.1871 Boehringer Ingelheim Investigational Site

Marburg, Germany

Location

205.389.1926 Boehringer Ingelheim Investigational Site

Marburg, Germany

Location

205.389.1776 Boehringer Ingelheim Investigational Site

Marl, Germany

Location

205.389.1779 Boehringer Ingelheim Investigational Site

Merrbusch, Germany

Location

205.389.1799 Boehringer Ingelheim Investigational Site

München, Germany

Location

205.389.1815 Boehringer Ingelheim Investigational Site

München, Germany

Location

205.389.1817 Boehringer Ingelheim Investigational Site

München, Germany

Location

205.389.1843 Boehringer Ingelheim Investigational Site

München, Germany

Location

205.389.1952 Boehringer Ingelheim Investigational Site

Neubrandenburg, Germany

Location

205.389.1805 Boehringer Ingelheim Investigational Site

Neuötting, Germany

Location

205.389.1948 Boehringer Ingelheim Investigational Site

Neuss, Germany

Location

205.389.1958 Boehringer Ingelheim Investigational Site

Neuwied, Germany

Location

205.389.1830 Boehringer Ingelheim Investigational Site

Niesky, Germany

Location

205.389.1711 Boehringer Ingelheim Investigational Site

Nußbach, Germany

Location

205.389.1781 Boehringer Ingelheim Investigational Site

Oberdorla, Germany

Location

205.389.1753 Boehringer Ingelheim Investigational Site

Paderborn, Germany

Location

205.389.1810 Boehringer Ingelheim Investigational Site

Paderborn, Germany

Location

205.389.1854 Boehringer Ingelheim Investigational Site

Paderborn, Germany

Location

205.389.1756 Boehringer Ingelheim Investigational Site

Pirmasens, Germany

Location

205.389.1794 Boehringer Ingelheim Investigational Site

Potsdam, Germany

Location

205.389.1899 Boehringer Ingelheim Investigational Site

Potsdam, Germany

Location

205.389.1842 Boehringer Ingelheim Investigational Site

Radebeul, Germany

Location

205.389.1897 Boehringer Ingelheim Investigational Site

Rathenow, Germany

Location

205.389.1950 Boehringer Ingelheim Investigational Site

Raubach, Germany

Location

205.389.1783 Boehringer Ingelheim Investigational Site

Riesa, Germany

Location

205.389.1826 Boehringer Ingelheim Investigational Site

Riesa, Germany

Location

205.389.1742 Boehringer Ingelheim Investigational Site

Rostock, Germany

Location

205.389.1816 Boehringer Ingelheim Investigational Site

Rüdersdorf, Germany

Location

205.389.1883 Boehringer Ingelheim Investigational Site

Rüsselsheim am Main, Germany

Location

205.389.1878 Boehringer Ingelheim Investigational Site

Saarlouis, Germany

Location

205.389.1833 Boehringer Ingelheim Investigational Site

Schmallenberg-Grafschaft, Germany

Location

205.389.1973 Boehringer Ingelheim Investigational Site

Schmölln, Germany

Location

205.389.1979 Boehringer Ingelheim Investigational Site

Schwetzingen, Germany

Location

205.389.1856 Boehringer Ingelheim Investigational Site

Simmern, Germany

Location

205.389.1918 Boehringer Ingelheim Investigational Site

Solingen, Germany

Location

205.389.1822 Boehringer Ingelheim Investigational Site

Steinfurt, Germany

Location

205.389.1728 Boehringer Ingelheim Investigational Site

Sulzbach, Germany

Location

205.389.1717 Boehringer Ingelheim Investigational Site

Templin, Germany

Location

205.389.1882 Boehringer Ingelheim Investigational Site

Treuenbrietzen, Germany

Location

205.389.1745 Boehringer Ingelheim Investigational Site

Wallerfing, Germany

Location

205.389.1800 Boehringer Ingelheim Investigational Site

Wardenburg, Germany

Location

205.389.1885 Boehringer Ingelheim Investigational Site

Weißenhorn, Germany

Location

205.389.1927 Boehringer Ingelheim Investigational Site

Westerstede, Germany

Location

205.389.1825 Boehringer Ingelheim Investigational Site

Weyhe, Germany

Location

205.389.1863 Boehringer Ingelheim Investigational Site

Wiesbaden, Germany

Location

205.389.1968 Boehringer Ingelheim Investigational Site

Wilhelmshaven, Germany

Location

205.389.1807 Boehringer Ingelheim Investigational Site

Wilster, Germany

Location

205.389.1754 Boehringer Ingelheim Investigational Site

Wolfsburg, Germany

Location

205.389.1919 Boehringer Ingelheim Investigational Site

Wuppertal, Germany

Location

205.389.1898 Boehringer Ingelheim Investigational Site

Zerbst, Germany

Location

205.389.2001 Boehringer Ingelheim Investigational Site

Budapest, Hungary

Location

205.389.2005 Boehringer Ingelheim Investigational Site

Budapest, Hungary

Location

205.389.2006 Boehringer Ingelheim Investigational Site

Budapest, Hungary

Location

205.389.2009 Boehringer Ingelheim Investigational Site

Budapest, Hungary

Location

205.389.2016 Boehringer Ingelheim Investigational Site

Budapest, Hungary

Location

205.389.2018 Boehringer Ingelheim Investigational Site

Budapest, Hungary

Location

205.389.2027 Boehringer Ingelheim Investigational Site

Budapest, Hungary

Location

205.389.2007 Boehringer Ingelheim Investigational Site

Debrecen, Hungary

Location

205.389.2035 Boehringer Ingelheim Investigational Site

Deszk, Hungary

Location

205.389.2015 Boehringer Ingelheim Investigational Site

Dunaújváros, Hungary

Location

205.389.2008 Boehringer Ingelheim Investigational Site

Érd, Hungary

Location

205.389.2011 Boehringer Ingelheim Investigational Site

Füzesabony, Hungary

Location

205.389.2013 Boehringer Ingelheim Investigational Site

Győr, Hungary

Location

205.389.2028 Boehringer Ingelheim Investigational Site

Gyula, Hungary

Location

205.389.2014 Boehringer Ingelheim Investigational Site

Jászberény, Hungary

Location

205.389.2021 Boehringer Ingelheim Investigational Site

Kecskemét, Hungary

Location

205.389.2025 Boehringer Ingelheim Investigational Site

Komárom, Hungary

Location

205.389.2024 Boehringer Ingelheim Investigational Site

Mosdós, Hungary

Location

205.389.2026 Boehringer Ingelheim Investigational Site

Mosonmagyaróvár, Hungary

Location

205.389.2031 Boehringer Ingelheim Investigational Site

Nyíregyháza, Hungary

Location

205.389.2002 Boehringer Ingelheim Investigational Site

Pécs, Hungary

Location

205.389.2017 Boehringer Ingelheim Investigational Site

Ráckeve, Hungary

Location

205.389.2003 Boehringer Ingelheim Investigational Site

Siófok, Hungary

Location

205.389.2010 Boehringer Ingelheim Investigational Site

Szarvas, Hungary

Location

205.389.2022 Boehringer Ingelheim Investigational Site

Százhalombatta, Hungary

Location

205.389.2019 Boehringer Ingelheim Investigational Site

Szentendre, Hungary

Location

205.389.2030 Boehringer Ingelheim Investigational Site

Tatabánya, Hungary

Location

205.389.2029 Boehringer Ingelheim Investigational Site

Törökbálint, Hungary

Location

205.389.2020 Boehringer Ingelheim Investigational Site

Veszprém, Hungary

Location

205.389.2101 Boehringer Ingelheim Investigational Site

Afula, Israel

Location

205.389.2110 Boehringer Ingelheim Investigational Site

Ashkelon, Israel

Location

205.389.2106 Boehringer Ingelheim Investigational Site

Beersheba, Israel

Location

205.389.2112 Boehringer Ingelheim Investigational Site

Hadera, Israel

Location

205.389.2107 Boehringer Ingelheim Investigational Site

Haifa, Israel

Location

205.389.2111 Boehringer Ingelheim Investigational Site

Haifa, Israel

Location

205.389.2108 Boehringer Ingelheim Investigational Site

Holon, Israel

Location

205.389.2104 Boehringer Ingelheim Investigational Site

Jerusalem, Israel

Location

205.389.2114 Boehringer Ingelheim Investigational Site

Jerusalem, Israel

Location

205.389.2116 Boehringer Ingelheim Investigational Site

Nahariya, Israel

Location

205.389.2102 Boehringer Ingelheim Investigational Site

Petah Tikva, Israel

Location

205.389.2105 Boehringer Ingelheim Investigational Site

Rehovot, Israel

Location

205.389.2103 Boehringer Ingelheim Investigational Site

Tel Litwinsky, Israel

Location

205.389.2117 Boehringer Ingelheim Investigational Site

Ẕerifin, Israel

Location

205.389.2211 Boehringer Ingelheim Investigational Site

Brescia, Italy

Location

205.389.2206 Boehringer Ingelheim Investigational Site

Cagliari, Italy

Location

205.389.2223 Boehringer Ingelheim Investigational Site

Catania, Italy

Location

205.389.2209 Boehringer Ingelheim Investigational Site

Ferrara, Italy

Location

205.389.2214 Boehringer Ingelheim Investigational Site

Genova, Italy

Location

205.389.2215 Boehringer Ingelheim Investigational Site

Lecco, Italy

Location

205.389.2221 Boehringer Ingelheim Investigational Site

Milan, Italy

Location

205.389.2226 Boehringer Ingelheim Investigational Site

Milan, Italy

Location

205.389.2224 Boehringer Ingelheim Investigational Site

Modena, Italy

Location

205.389.2203 Boehringer Ingelheim Investigational Site

Montescano (PV), Italy

Location

205.389.2230 Boehringer Ingelheim Investigational Site

Napoli, Italy

Location

205.389.2201 Boehringer Ingelheim Investigational Site

Novara, Italy

Location

205.389.2229 Boehringer Ingelheim Investigational Site

Pavia, Italy

Location

205.389.2227 Boehringer Ingelheim Investigational Site

Pisa, Italy

Location

205.389.2205 Boehringer Ingelheim Investigational Site

Roma, Italy

Location

205.389.2228 Boehringer Ingelheim Investigational Site

Roma, Italy

Location

205.389.2210 Boehringer Ingelheim Investigational Site

Sassari, Italy

Location

205.389.2232 Boehringer Ingelheim Investigational Site

Treviso, Italy

Location

205.389.2315 Boehringer Ingelheim Investigational Site

Balvi, Latvia

Location

205.389.2305 Boehringer Ingelheim Investigational Site

Daugavpils, Latvia

Location

205.389.2313 Boehringer Ingelheim Investigational Site

Jelgava, Latvia

Location

205.389.2311 Boehringer Ingelheim Investigational Site

Krāslava, Latvia

Location

205.389.2312 Boehringer Ingelheim Investigational Site

Kuldīga, Latvia

Location

205.389.2301 Boehringer Ingelheim Investigational Site

Riga, Latvia

Location

205.389.2303 Boehringer Ingelheim Investigational Site

Riga, Latvia

Location

205.389.2307 Boehringer Ingelheim Investigational Site

Riga, Latvia

Location

205.389.2310 Boehringer Ingelheim Investigational Site

Riga, Latvia

Location

205.389.2306 Boehringer Ingelheim Investigational Site

Talsi, Latvia

Location

205.389.2314 Boehringer Ingelheim Investigational Site

Tukums, Latvia

Location

205.389.2304 Boehringer Ingelheim Investigational Site

Valmiera, Latvia

Location

205.389.2302 Boehringer Ingelheim Investigational Site

Ventspils, Latvia

Location

205.389.2401 Boehringer Ingelheim Investigational Site

Alytus, Lithuania

Location

205.389.2402 Boehringer Ingelheim Investigational Site

Kaunas, Lithuania

Location

205.389.2403 Boehringer Ingelheim Investigational Site

Kaunas, Lithuania

Location

205.389.2404 Boehringer Ingelheim Investigational Site

Kaunas, Lithuania

Location

205.389.2406 Boehringer Ingelheim Investigational Site

Kaunas, Lithuania

Location

205.389.2409 Boehringer Ingelheim Investigational Site

Kaunas, Lithuania

Location

205.389.2407 Boehringer Ingelheim Investigational Site

Klaipėda, Lithuania

Location

205.389.2411 Boehringer Ingelheim Investigational Site

Klaipėda, Lithuania

Location

205.389.2408 Boehringer Ingelheim Investigational Site

Šiauliai, Lithuania

Location

205.389.2410 Boehringer Ingelheim Investigational Site

Utena, Lithuania

Location

205.389.2405 Boehringer Ingelheim Investigational Site

Vilnius, Lithuania

Location

205.389.2412 Boehringer Ingelheim Investigational Site

Vilnius, Lithuania

Location

205.389.2413 Boehringer Ingelheim Investigational Site

Vilnius, Lithuania

Location

205.389.2414 Boehringer Ingelheim Investigational Site

Vilnius, Lithuania

Location

205.389.2504 Boehringer Ingelheim Investigational Site

Rotterdam, Netherlands

Location

205.389.2508 Boehringer Ingelheim Investigational Site

Te Leiderdrop, Netherlands

Location

205.389.2510 Boehringer Ingelheim Investigational Site

Velp, Netherlands

Location

205.389.2511 Boehringer Ingelheim Investigational Site

Zoetermeer, Netherlands

Location

205.389.2614 Boehringer Ingelheim Investigational Site

Ålesund, Norway

Location

205.389.2604 Boehringer Ingelheim Investigational Site

Bekkestua, Norway

Location

205.389.2601 Boehringer Ingelheim Investigational Site

Elverum, Norway

Location

205.389.2611 Boehringer Ingelheim Investigational Site

Follebu, Norway

Location

205.389.2602 Boehringer Ingelheim Investigational Site

Hamar, Norway

Location

205.389.2610 Boehringer Ingelheim Investigational Site

Harstad, Norway

Location

205.389.2613 Boehringer Ingelheim Investigational Site

Harstad, Norway

Location

205.389.2609 Boehringer Ingelheim Investigational Site

Hønefoss, Norway

Location

205.389.2608 Boehringer Ingelheim Investigational Site

Lørenskog, Norway

Location

205.389.2605 Boehringer Ingelheim Investigational Site

Oslo, Norway

Location

205.389.2612 Boehringer Ingelheim Investigational Site

Oslo, Norway

Location

205.389.2616 Boehringer Ingelheim Investigational Site

Stavanger, Norway

Location

205.389.2708 Boehringer Ingelheim Investigational Site

Bialystok, Poland

Location

205.389.2744 Boehringer Ingelheim Investigational Site

Bialystok, Poland

Location

205.389.2762 Boehringer Ingelheim Investigational Site

Bialystok, Poland

Location

205.389.2765 Boehringer Ingelheim Investigational Site

Bialystok, Poland

Location

205.389.2778 Boehringer Ingelheim Investigational Site

Bielsko-Biala, Poland

Location

205.389.2706 Boehringer Ingelheim Investigational Site

Bieńkówka, Poland

Location

205.389.2750 Boehringer Ingelheim Investigational Site

Brzesko, Poland

Location

205.389.2758 Boehringer Ingelheim Investigational Site

Bydgoszcz, Poland

Location

205.389.2773 Boehringer Ingelheim Investigational Site

Bystra, Poland

Location

205.389.2800 Boehringer Ingelheim Investigational Site

Chodzież, Poland

Location

205.389.2712 Boehringer Ingelheim Investigational Site

Częstochowa, Poland

Location

205.389.2774 Boehringer Ingelheim Investigational Site

Częstochowa, Poland

Location

205.389.2815 Boehringer Ingelheim Investigational Site

Działdowo, Poland

Location

205.389.2787 Boehringer Ingelheim Investigational Site

Elblag, Poland

Location

205.389.2715 Boehringer Ingelheim Investigational Site

Gdansk, Poland

Location

205.389.2723 Boehringer Ingelheim Investigational Site

Gdansk, Poland

Location

205.389.2743 Boehringer Ingelheim Investigational Site

Gdansk, Poland

Location

205.389.2764 Boehringer Ingelheim Investigational Site

Gdansk, Poland

Location

205.389.2802 Boehringer Ingelheim Investigational Site

Gdansk, Poland

Location

205.389.2801 Boehringer Ingelheim Investigational Site

Gorzow Wlkp, Poland

Location

205.389.2791 Boehringer Ingelheim Investigational Site

Inowrocław, Poland

Location

205.389.2805 Boehringer Ingelheim Investigational Site

Iława, Poland

Location

205.389.2705 Boehringer Ingelheim Investigational Site

Katowice, Poland

Location

205.389.2749 Boehringer Ingelheim Investigational Site

Katowice, Poland

Location

205.389.2771 Boehringer Ingelheim Investigational Site

Katowice, Poland

Location

205.389.2759 Boehringer Ingelheim Investigational Site

Koszalin, Poland

Location

205.389.2711 Boehringer Ingelheim Investigational Site

Krakow, Poland

Location

205.389.2722 Boehringer Ingelheim Investigational Site

Krakow, Poland

Location

205.389.2747 Boehringer Ingelheim Investigational Site

Krakow, Poland

Location

205.389.2748 Boehringer Ingelheim Investigational Site

Krakow, Poland

Location

205.389.2753 Boehringer Ingelheim Investigational Site

Krakow, Poland

Location

205.389.2798 Boehringer Ingelheim Investigational Site

Krakow, Poland

Location

205.389.2757 Boehringer Ingelheim Investigational Site

Kutno, Poland

Location

205.389.2727 Boehringer Ingelheim Investigational Site

Leszno, Poland

Location

205.389.2701 Boehringer Ingelheim Investigational Site

Lodz, Poland

Location

205.389.2709 Boehringer Ingelheim Investigational Site

Lodz, Poland

Location

205.389.2716 Boehringer Ingelheim Investigational Site

Lodz, Poland

Location

205.389.2724 Boehringer Ingelheim Investigational Site

Lodz, Poland

Location

205.389.2732 Boehringer Ingelheim Investigational Site

Lodz, Poland

Location

205.389.2746 Boehringer Ingelheim Investigational Site

Lodz, Poland

Location

205.389.2751 Boehringer Ingelheim Investigational Site

Lodz, Poland

Location

205.389.2741 Boehringer Ingelheim Investigational Site

Lublin, Poland

Location

205.389.2776 Boehringer Ingelheim Investigational Site

Lublin, Poland

Location

205.389.2817 Boehringer Ingelheim Investigational Site

Lublin, Poland

Location

205.389.2756 Boehringer Ingelheim Investigational Site

Olsztyn, Poland

Location

205.389.2816 Boehringer Ingelheim Investigational Site

Olsztyn, Poland

Location

205.389.2702 Boehringer Ingelheim Investigational Site

Ostrow Wielkopolska, Poland

Location

205.389.2760 Boehringer Ingelheim Investigational Site

Oława, Poland

Location

205.389.2726 Boehringer Ingelheim Investigational Site

Pabianice, Poland

Location

205.389.2703 Boehringer Ingelheim Investigational Site

Poznan, Poland

Location

205.389.2719 Boehringer Ingelheim Investigational Site

Poznan, Poland

Location

205.389.2737 Boehringer Ingelheim Investigational Site

Poznan, Poland

Location

205.389.2766 Boehringer Ingelheim Investigational Site

Poznan, Poland

Location

205.389.2769 Boehringer Ingelheim Investigational Site

Poznan, Poland

Location

205.389.2813 Boehringer Ingelheim Investigational Site

Poznan, Poland

Location

205.389.2763 Boehringer Ingelheim Investigational Site

Proszowice, Poland

Location

205.389.2767 Boehringer Ingelheim Investigational Site

Pruszków, Poland

Location

205.389.2795 Boehringer Ingelheim Investigational Site

Pławno, Poland

Location

205.389.2730 Boehringer Ingelheim Investigational Site

Płock, Poland

Location

205.389.2768 Boehringer Ingelheim Investigational Site

Radom, Poland

Location

205.389.2792 Boehringer Ingelheim Investigational Site

Sandomierz, Poland

Location

205.389.2781 Boehringer Ingelheim Investigational Site

Sieradz, Poland

Location

205.389.2725 Boehringer Ingelheim Investigational Site

Skierniewice, Poland

Location

205.389.2718 Boehringer Ingelheim Investigational Site

Szczecin, Poland

Location

205.389.2739 Boehringer Ingelheim Investigational Site

Szczecin, Poland

Location

205.389.2772 Boehringer Ingelheim Investigational Site

Szczecin, Poland

Location

205.389.2777 Boehringer Ingelheim Investigational Site

Szczecin - Zdunowo, Poland

Location

205.389.2782 Boehringer Ingelheim Investigational Site

Szczecin - Zdunowo, Poland

Location

205.389.2738 Boehringer Ingelheim Investigational Site

Tarnów, Poland

Location

205.389.2799 Boehringer Ingelheim Investigational Site

Tarnów, Poland

Location

205.389.2810 Boehringer Ingelheim Investigational Site

Tczew, Poland

Location

205.389.2775 Boehringer Ingelheim Investigational Site

Torun, Poland

Location

205.389.2754 Boehringer Ingelheim Investigational Site

Tranow, Poland

Location

205.389.2806 Boehringer Ingelheim Investigational Site

Turek, Poland

Location

205.389.2803 Boehringer Ingelheim Investigational Site

Wabrzenzo, Poland

Location

205.389.2707 Boehringer Ingelheim Investigational Site

Warsaw, Poland

Location

205.389.2714 Boehringer Ingelheim Investigational Site

Warsaw, Poland

Location

205.389.2728 Boehringer Ingelheim Investigational Site

Warsaw, Poland

Location

205.389.2734 Boehringer Ingelheim Investigational Site

Warsaw, Poland

Location

205.389.2812 Boehringer Ingelheim Investigational Site

Warsaw, Poland

Location

205.389.2818 Boehringer Ingelheim Investigational Site

Warsaw, Poland

Location

205.389.2710 Boehringer Ingelheim Investigational Site

Wodzisław Śląski, Poland

Location

205.389.2721 Boehringer Ingelheim Investigational Site

Wroclaw, Poland

Location

205.389.2731 Boehringer Ingelheim Investigational Site

Wroclaw, Poland

Location

205.389.2736 Boehringer Ingelheim Investigational Site

Wroclaw, Poland

Location

205.389.2752 Boehringer Ingelheim Investigational Site

Wroclaw, Poland

Location

205.389.2761 Boehringer Ingelheim Investigational Site

Wroclaw, Poland

Location

205.389.2780 Boehringer Ingelheim Investigational Site

Wroclaw, Poland

Location

205.389.2793 Boehringer Ingelheim Investigational Site

Wroclaw, Poland

Location

205.389.2783 Boehringer Ingelheim Investigational Site

Zabrze, Poland

Location

205.389.2735 Boehringer Ingelheim Investigational Site

Zakopane, Poland

Location

205.389.2770 Boehringer Ingelheim Investigational Site

Zgierz, Poland

Location

205.389.2804 Boehringer Ingelheim Investigational Site

Łomża, Poland

Location

205.389.2912 Boehringer Ingelheim Investigational Site

Angra do Heroísmo, Portugal

Location

205.389.2911 Boehringer Ingelheim Investigational Site

Barreiro, Portugal

Location

205.389.2904 Boehringer Ingelheim Investigational Site

Faro, Portugal

Location

205.389.2910 Boehringer Ingelheim Investigational Site

Figueira da Foz Municipality, Portugal

Location

205.389.2907 Boehringer Ingelheim Investigational Site

Guarda, Portugal

Location

205.389.2914 Boehringer Ingelheim Investigational Site

Lisbon, Portugal

Location

205.389.2917 Boehringer Ingelheim Investigational Site

Lisbon, Portugal

Location

205.389.2905 Boehringer Ingelheim Investigational Site

Santa Maria da Feira, Portugal

Location

205.389.2909 Boehringer Ingelheim Investigational Site

Santiago do Cacém, Portugal

Location

205.389.2903 Boehringer Ingelheim Investigational Site

Torres Vedras, Portugal

Location

205.389.3009 Boehringer Ingelheim Investigational Site

Brasov, Romania

Location

205.389.3018 Boehringer Ingelheim Investigational Site

Brasov, Romania

Location

205.389.3023 Boehringer Ingelheim Investigational Site

Brasov, Romania

Location

205.389.3001 Boehringer Ingelheim Investigational Site

Bucharest, Romania

Location

205.389.3002 Boehringer Ingelheim Investigational Site

Bucharest, Romania

Location

205.389.3004 Boehringer Ingelheim Investigational Site

Bucharest, Romania

Location

205.389.3006 Boehringer Ingelheim Investigational Site

Bucharest, Romania

Location

205.389.3007 Boehringer Ingelheim Investigational Site

Bucharest, Romania

Location

205.389.3012 Boehringer Ingelheim Investigational Site

Bucharest, Romania

Location

205.389.3013 Boehringer Ingelheim Investigational Site

Bucharest, Romania

Location

205.389.3025 Boehringer Ingelheim Investigational Site

Bucharest, Romania

Location

205.389.3016 Boehringer Ingelheim Investigational Site

Constanța, Romania

Location

205.389.3019 Boehringer Ingelheim Investigational Site

Constanța, Romania

Location

205.389.3015 Boehringer Ingelheim Investigational Site

Craiova, Romania

Location

205.389.3008 Boehringer Ingelheim Investigational Site

Iași, Romania

Location

205.389.3014 Boehringer Ingelheim Investigational Site

Iași, Romania

Location

205.389.3022 Boehringer Ingelheim Investigational Site

Iași, Romania

Location

205.389.3024 Boehringer Ingelheim Investigational Site

Iași, Romania

Location

205.389.3005 Boehringer Ingelheim Investigational Site

Oradea, Romania

Location

205.389.3017 Boehringer Ingelheim Investigational Site

Tg. Mures, Romania

Location

205.389.3021 Boehringer Ingelheim Investigational Site

Timișoara, Romania

Location

205.389.3174 Boehringer Ingelheim Investigational Site

Arkhangelsk, Russia

Location

205.389.3113 Boehringer Ingelheim Investigational Site

Barnaul, Russia

Location

205.389.3131 Boehringer Ingelheim Investigational Site

Barnaul, Russia

Location

205.389.3105 Boehringer Ingelheim Investigational Site

Chelyabinsk, Russia

Location

205.389.3182 Boehringer Ingelheim Investigational Site

Chelyabinsk, Russia

Location

205.389.3183 Boehringer Ingelheim Investigational Site

Chelyabinsk, Russia

Location

205.389.3184 Boehringer Ingelheim Investigational Site

Chelyabinsk, Russia

Location

205.389.3186 Boehringer Ingelheim Investigational Site

Gatchina (Leningradskaya Oblast), Russia

Location

205.389.3193 Boehringer Ingelheim Investigational Site

Kaliningrad, Russia

Location

205.389.3104 Boehringer Ingelheim Investigational Site

Kazan', Russia

Location

205.389.3111 Boehringer Ingelheim Investigational Site

Kemerovo, Russia

Location

205.389.3120 Boehringer Ingelheim Investigational Site

Kirov, Russia

Location

205.389.3170 Boehringer Ingelheim Investigational Site

Krasnodar, Russia

Location

205.389.3132 Boehringer Ingelheim Investigational Site

Krasnoyarsk, Russia

Location

205.389.3103 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3106 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3107 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3108 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3109 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3125 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3127 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3128 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3130 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3134 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3136 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3139 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3140 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3143 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3149 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3151 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3156 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3157 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3163 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3164 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3167 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3168 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3171 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3196 Boehringer Ingelheim Investigational Site

Moscow, Russia

Location

205.389.3188 Boehringer Ingelheim Investigational Site

Murmansk, Russia

Location

205.389.3169 Boehringer Ingelheim Investigational Site

Nizhny Novgorod, Russia

Location

205.389.3953 Boehringer Ingelheim Investigational Site

Nizhny Novgorod, Russia

Location

205.389.3112 Boehringer Ingelheim Investigational Site

Novosibirsk, Russia

Location

205.389.3114 Boehringer Ingelheim Investigational Site

Novosibirsk, Russia

Location

205.389.3129 Boehringer Ingelheim Investigational Site

Novosibirsk, Russia

Location

205.389.3141 Boehringer Ingelheim Investigational Site

Novosibirsk, Russia

Location

205.389.3153 Boehringer Ingelheim Investigational Site

Novosibirsk, Russia

Location

205.389.3175 Boehringer Ingelheim Investigational Site

Novosibirsk, Russia

Location

205.389.3126 Boehringer Ingelheim Investigational Site

Orenburg, Russia

Location

205.389.3185 Boehringer Ingelheim Investigational Site

Perm, Russia

Location

205.389.3192 Boehringer Ingelheim Investigational Site

Petrozavodsk, Russia

Location

205.389.3179 Boehringer Ingelheim Investigational Site

Pskov, Russia

Location

205.389.3190 Boehringer Ingelheim Investigational Site

Pskov, Russia

Location

205.389.3199 Boehringer Ingelheim Investigational Site

Pyatigorsk, Russia

Location

205.389.3159 Boehringer Ingelheim Investigational Site

Rostov-on-Don, Russia

Location

205.389.3197 Boehringer Ingelheim Investigational Site

Ryazan, Russia

Location

205.389.3117 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3119 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3121 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3122 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3123 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3135 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3137 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3145 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3146 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3147 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3152 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3160 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3161 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3176 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3177 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3178 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3180 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3181 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3189 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3191 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3195 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3198 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3950 Boehringer Ingelheim Investigational Site

Saint Petersburg, Russia

Location

205.389.3110 Boehringer Ingelheim Investigational Site

Saratov, Russia

Location

205.389.3951 Boehringer Ingelheim Investigational Site

Saratov, Russia

Location

205.389.3165 Boehringer Ingelheim Investigational Site

St.Peterburg, Russia

Location

205.389.3101 Boehringer Ingelheim Investigational Site

Tomsk, Russia

Location

205.389.3102 Boehringer Ingelheim Investigational Site

Tomsk, Russia

Location

205.389.3133 Boehringer Ingelheim Investigational Site

Tomsk, Russia

Location

205.389.3144 Boehringer Ingelheim Investigational Site

Tomsk, Russia

Location

205.389.3194 Boehringer Ingelheim Investigational Site

Veliky Novgorod, Russia

Location

205.389.3118 Boehringer Ingelheim Investigational Site

Yaroslavl, Russia

Location

205.389.3155 Boehringer Ingelheim Investigational Site

Yaroslavl, Russia

Location

205.389.3116 Boehringer Ingelheim Investigational Site

Yekaterinburg, Russia

Location

205.389.3138 Boehringer Ingelheim Investigational Site

Yekaterinburg, Russia

Location

205.389.3148 Boehringer Ingelheim Investigational Site

Yekaterinburg, Russia

Location

205.389.3166 Boehringer Ingelheim Investigational Site

Yekaterinburg, Russia

Location

205.389.3208 Boehringer Ingelheim Investigational Site

Bratislava, Slovakia

Location

205.389.3204 Boehringer Ingelheim Investigational Site

Košice, Slovakia

Location

205.389.3209 Boehringer Ingelheim Investigational Site

Košice, Slovakia

Location

205.389.3205 Boehringer Ingelheim Investigational Site

Prievidza, Slovakia

Location

205.389.3210 Boehringer Ingelheim Investigational Site

Revúca, Slovakia

Location

205.389.3203 Boehringer Ingelheim Investigational Site

Spišská Nová Ves, Slovakia

Location

205.389.3202 Boehringer Ingelheim Investigational Site

Trnava, Slovakia

Location

205.389.3207 Boehringer Ingelheim Investigational Site

Vráble, Slovakia

Location

205.389.3301 Boehringer Ingelheim Investigational Site

Golnik, Slovenia

Location

205.389.3308 Boehringer Ingelheim Investigational Site

Grosuplje, Slovenia

Location

205.389.3304 Boehringer Ingelheim Investigational Site

Jesenice, Slovenia

Location

205.389.3302 Boehringer Ingelheim Investigational Site

Kamnik, Slovenia

Location

205.389.3303 Boehringer Ingelheim Investigational Site

Ljubljana, Slovenia

Location

205.389.3306 Boehringer Ingelheim Investigational Site

Topolšica, Slovenia

Location

205.389.3410 Boehringer Ingelheim Investigational Site

Badajoz, Spain

Location

205.389.3403 Boehringer Ingelheim Investigational Site

Badalona (Barcelona), Spain

Location

205.389.3401 Boehringer Ingelheim Investigational Site

Barcelona, Spain

Location

205.389.3402 Boehringer Ingelheim Investigational Site

Barcelona, Spain

Location

205.389.3428 Boehringer Ingelheim Investigational Site

Barcelona, Spain

Location

205.389.3430 Boehringer Ingelheim Investigational Site

Cartagena, Spain

Location

205.389.3416 Boehringer Ingelheim Investigational Site

Cáceres, Spain

Location

205.389.3425 Boehringer Ingelheim Investigational Site

Elche, Spain

Location

205.389.3408 Boehringer Ingelheim Investigational Site

Las Palmas de Gran Canarias, Spain

Location

205.389.3405 Boehringer Ingelheim Investigational Site

Lleida, Spain

Location

205.389.3404 Boehringer Ingelheim Investigational Site

Madrid, Spain

Location

205.389.3406 Boehringer Ingelheim Investigational Site

Madrid, Spain

Location

205.389.3414 Boehringer Ingelheim Investigational Site

Málaga, Spain

Location

205.389.3431 Boehringer Ingelheim Investigational Site

Pontevedra, Spain

Location

205.389.3419 Boehringer Ingelheim Investigational Site

Requena, Spain

Location

205.389.3427 Boehringer Ingelheim Investigational Site

Reus, Spain

Location

205.389.3422 Boehringer Ingelheim Investigational Site

Sagunto, Spain

Location

205.389.3420 Boehringer Ingelheim Investigational Site

San Juan, Spain

Location

205.389.3415 Boehringer Ingelheim Investigational Site

Santander, Spain

Location

205.389.3421 Boehringer Ingelheim Investigational Site

Santiago de Compostela, Spain

Location

205.389.3407 Boehringer Ingelheim Investigational Site

Terrasa (Barcelona), Spain

Location

205.389.3413 Boehringer Ingelheim Investigational Site

Valencia, Spain

Location

205.389.3426 Boehringer Ingelheim Investigational Site

Valencia, Spain

Location

205.389.3417 Boehringer Ingelheim Investigational Site

Valladolid, Spain

Location

205.389.3821 Boehringer Ingelheim Investigational Site

Adana, Turkey (Türkiye)

Location

205.389.3808 Boehringer Ingelheim Investigational Site

Ankara, Turkey (Türkiye)

Location

205.389.3810 Boehringer Ingelheim Investigational Site

Ankara, Turkey (Türkiye)

Location

205.389.3817 Boehringer Ingelheim Investigational Site

Bursa, Turkey (Türkiye)

Location

205.389.3819 Boehringer Ingelheim Investigational Site

Erzurum, Turkey (Türkiye)

Location

205.389.3812 Boehringer Ingelheim Investigational Site

Istanbul, Turkey (Türkiye)

Location

205.389.3827 Boehringer Ingelheim Investigational Site

Izmir, Turkey (Türkiye)

Location

205.389.3813 Boehringer Ingelheim Investigational Site

İzmit, Turkey (Türkiye)

Location

205.389.3820 Boehringer Ingelheim Investigational Site

Kahramanmaraş, Turkey (Türkiye)

Location

205.389.3825 Boehringer Ingelheim Investigational Site

Malatya, Turkey (Türkiye)

Location

205.389.3809 Boehringer Ingelheim Investigational Site

Sihhiye Ankara, Turkey (Türkiye)

Location

205.389.3807 Boehringer Ingelheim Investigational Site

Yenisehir-IZMIR, Turkey (Türkiye)

Location

205.389.3521 Boehringer Ingelheim Investigational Site

AR Crimea, Ukraine

Location

205.389.3516 Boehringer Ingelheim Investigational Site

Cherkassy, Ukraine

Location

205.389.3549 Boehringer Ingelheim Investigational Site

Chernivtsi, Ukraine

Location

205.389.3509 Boehringer Ingelheim Investigational Site

Dnipropetrovsk, Ukraine

Location

205.389.3510 Boehringer Ingelheim Investigational Site

Dnipropetrovsk, Ukraine

Location

205.389.3511 Boehringer Ingelheim Investigational Site

Dnipropetrovsk, Ukraine

Location

205.389.3523 Boehringer Ingelheim Investigational Site

Dnipropetrovsk, Ukraine

Location

205.389.3514 Boehringer Ingelheim Investigational Site

Donetsk, Ukraine

Location

205.389.3524 Boehringer Ingelheim Investigational Site

Donetsk, Ukraine

Location

205.389.3533 Boehringer Ingelheim Investigational Site

Ivano-Frankivsk, Ukraine

Location

205.389.3506 Boehringer Ingelheim Investigational Site

Kharkiv, Ukraine

Location

205.389.3507 Boehringer Ingelheim Investigational Site

Kharkiv, Ukraine

Location

205.389.3508 Boehringer Ingelheim Investigational Site

Kharkiv, Ukraine

Location

205.389.3520 Boehringer Ingelheim Investigational Site

Kharkiv, Ukraine

Location

205.389.3522 Boehringer Ingelheim Investigational Site

Kharkiv, Ukraine

Location

205.389.3532 Boehringer Ingelheim Investigational Site

Kharkiv, Ukraine

Location

205.389.3539 Boehringer Ingelheim Investigational Site

Kharkiv, Ukraine

Location

205.389.3541 Boehringer Ingelheim Investigational Site

Kharkiv, Ukraine

Location

205.389.3543 Boehringer Ingelheim Investigational Site

Kharkiv, Ukraine

Location

205.389.3555 Boehringer Ingelheim Investigational Site

Kharkiv, Ukraine

Location

205.389.3501 Boehringer Ingelheim Investigational Site

Kiev, Ukraine

Location

205.389.3502 Boehringer Ingelheim Investigational Site

Kiev, Ukraine

Location

205.389.3503 Boehringer Ingelheim Investigational Site

Kiev, Ukraine

Location

205.389.3550 Boehringer Ingelheim Investigational Site

Kiev, Ukraine

Location

205.389.3552 Boehringer Ingelheim Investigational Site

Kiev, Ukraine

Location

205.389.3553 Boehringer Ingelheim Investigational Site

Kiev, Ukraine

Location

205.389.3504 Boehringer Ingelheim Investigational Site

Kyiv, Ukraine

Location

205.389.3525 Boehringer Ingelheim Investigational Site

Kyiv, Ukraine

Location

205.389.3526 Boehringer Ingelheim Investigational Site

Kyiv, Ukraine

Location

205.389.3528 Boehringer Ingelheim Investigational Site

Kyiv, Ukraine

Location

205.389.3534 Boehringer Ingelheim Investigational Site

Kyiv, Ukraine

Location

205.389.3535 Boehringer Ingelheim Investigational Site

Kyiv, Ukraine

Location

205.389.3536 Boehringer Ingelheim Investigational Site

Kyiv, Ukraine

Location

205.389.3538 Boehringer Ingelheim Investigational Site

Kyiv, Ukraine

Location

205.389.3551 Boehringer Ingelheim Investigational Site

Kyiv, Ukraine

Location

205.389.3545 Boehringer Ingelheim Investigational Site

Luhansk, Ukraine

Location

205.389.3512 Boehringer Ingelheim Investigational Site

Lviv, Ukraine

Location

205.389.3530 Boehringer Ingelheim Investigational Site

Lviv, Ukraine

Location

205.389.3540 Boehringer Ingelheim Investigational Site

Lviv, Ukraine

Location

205.389.3554 Boehringer Ingelheim Investigational Site

Lviv, Ukraine

Location

205.389.3556 Boehringer Ingelheim Investigational Site

m.Donetsk, Ukraine

Location

205.389.3513 Boehringer Ingelheim Investigational Site

m.Odesa, Ukraine

Location

205.389.3519 Boehringer Ingelheim Investigational Site

Odesa, Ukraine

Location

205.389.3527 Boehringer Ingelheim Investigational Site

Odesa, Ukraine

Location

205.389.3542 Boehringer Ingelheim Investigational Site

Odesa, Ukraine

Location

205.389.3531 Boehringer Ingelheim Investigational Site

Poltava, Ukraine

Location

205.389.3517 Boehringer Ingelheim Investigational Site

Simferopil, Ukraine

Location

205.389.3518 Boehringer Ingelheim Investigational Site

Ternopil, Ukraine

Location

205.389.3529 Boehringer Ingelheim Investigational Site

Vinnitsa, Ukraine

Location

205.389.3515 Boehringer Ingelheim Investigational Site

Zaporizhzhya, Ukraine

Location

205.389.3547 Boehringer Ingelheim Investigational Site

Zaporizhzhya, Ukraine

Location

205.389.3548 Boehringer Ingelheim Investigational Site

Zaporizhzhya, Ukraine

Location

205.389.3601 Boehringer Ingelheim Investigational Site

Bath, United Kingdom

Location

205.389.3630 Boehringer Ingelheim Investigational Site

Bexhill-on-Sea, United Kingdom

Location

205.389.3636 Boehringer Ingelheim Investigational Site

Bexhill-on-Sea, United Kingdom

Location

205.389.3608 Boehringer Ingelheim Investigational Site

Birmingham, United Kingdom

Location

205.389.3605 Boehringer Ingelheim Investigational Site

Blackburn, United Kingdom

Location

205.389.3609 Boehringer Ingelheim Investigational Site

Bolton, United Kingdom

Location

205.389.3640 Boehringer Ingelheim Investigational Site

Burbage, United Kingdom

Location

205.389.3643 Boehringer Ingelheim Investigational Site

Chesterfield, United Kingdom

Location

205.389.3627 Boehringer Ingelheim Investigational Site

Corsham, United Kingdom

Location

205.389.3606 Boehringer Ingelheim Investigational Site

Coventry, United Kingdom

Location

205.389.3633 Boehringer Ingelheim Investigational Site

Coventry, United Kingdom

Location

205.389.3639 Boehringer Ingelheim Investigational Site

Frome, United Kingdom

Location

205.389.3602 Boehringer Ingelheim Investigational Site

Glasgow, United Kingdom

Location

205.389.3632 Boehringer Ingelheim Investigational Site

Irvine, United Kingdom

Location

205.389.3623 Boehringer Ingelheim Investigational Site

London, United Kingdom

Location

205.389.3638 Boehringer Ingelheim Investigational Site

Middlesex, United Kingdom

Location

205.389.3616 Boehringer Ingelheim Investigational Site

Newcastle upon Tyne, United Kingdom

Location

205.389.3618 Boehringer Ingelheim Investigational Site

Paisley, United Kingdom

Location

205.389.3622 Boehringer Ingelheim Investigational Site

Radstock, United Kingdom

Location

205.389.3626 Boehringer Ingelheim Investigational Site

Randalstown, United Kingdom

Location

205.389.3613 Boehringer Ingelheim Investigational Site

Saint Just, Penzance, United Kingdom

Location

205.389.3604 Boehringer Ingelheim Investigational Site

Soham, United Kingdom

Location

205.389.3624 Boehringer Ingelheim Investigational Site

Sunderland, United Kingdom

Location

205.389.3635 Boehringer Ingelheim Investigational Site

Wansford, Peterborough, United Kingdom

Location

205.389.3631 Boehringer Ingelheim Investigational Site

Windsor, United Kingdom

Location

205.389.3612 Boehringer Ingelheim Investigational Site

Wrexham, United Kingdom

Location

Related Publications (6)

• Vogelmeier CF, Asijee GM, Kupas K, Beeh KM. Tiotropium and Salmeterol in COPD Patients at Risk of Exacerbations: A Post Hoc Analysis from POET-COPD((R)). Adv Ther. 2015 Jun;32(6):537-47. doi: 10.1007/s12325-015-0216-2. Epub 2015 Jun 23.

  PMID: 26100349 DERIVED

• Rabe KF, Fabbri LM, Israel E, Kogler H, Riemann K, Schmidt H, Glaab T, Vogelmeier CF. Effect of ADRB2 polymorphisms on the efficacy of salmeterol and tiotropium in preventing COPD exacerbations: a prespecified substudy of the POET-COPD trial. Lancet Respir Med. 2014 Jan;2(1):44-53. doi: 10.1016/S2213-2600(13)70248-0. Epub 2013 Dec 5.

  PMID: 24461901 DERIVED

• Beeh KM, Glaab T, Stowasser S, Schmidt H, Fabbri LM, Rabe KF, Vogelmeier CF. Characterisation of exacerbation risk and exacerbator phenotypes in the POET-COPD trial. Respir Res. 2013 Oct 29;14(1):116. doi: 10.1186/1465-9921-14-116.

  PMID: 24168767 DERIVED

• Rabe KF, Fabbri LM, Vogelmeier C, Kogler H, Schmidt H, Beeh KM, Glaab T. Seasonal distribution of COPD exacerbations in the Prevention of Exacerbations with Tiotropium in COPD trial. Chest. 2013 Mar;143(3):711-719. doi: 10.1378/chest.12-1277.

  PMID: 23188489 DERIVED

• Vogelmeier C, Hederer B, Glaab T, Schmidt H, Rutten-van Molken MP, Beeh KM, Rabe KF, Fabbri LM; POET-COPD Investigators. Tiotropium versus salmeterol for the prevention of exacerbations of COPD. N Engl J Med. 2011 Mar 24;364(12):1093-1103. doi: 10.1056/NEJMoa1008378.

  PMID: 21428765 DERIVED

• Beeh KM, Hederer B, Glaab T, Muller A, Rutten-van Moelken M, Kesten S, Vogelmeier C. Study design considerations in a large COPD trial comparing effects of tiotropium with salmeterol on exacerbations. Int J Chron Obstruct Pulmon Dis. 2009;4:119-25. Epub 2009 Apr 15.

  PMID: 19436693 DERIVED

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

Tiotropium Bromide; Salmeterol Xinafoate

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Scopolamine Derivatives; Tropanes; Azabicyclo Compounds; Aza Compounds; Organic Chemicals; Alkaloids; Heterocyclic Compounds; Bridged Bicyclo Compounds, Heterocyclic; Heterocyclic Compounds, Bridged-Ring; Albuterol; Ethanolamines; Amino Alcohols; Alcohols; Amines; Phenethylamines; Ethylamines

Results Point of Contact

• Title: Boehringer Ingelheim Call Center
• Organization: Boehringer Ingelheim Pharmaceuticals

clintriage.rdg@boehringer-ingelheim.com

1-800-243-0127

Study Officials

• Boehringer Ingelheim

  Boehringer Ingelheim

  STUDY CHAIR

Publication Agreements

• PI is Sponsor Employee: No
• Restriction Type: OTHER
• Restrictive Agreement: Yes

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY

Study Record Dates

• First Submitted: November 22, 2007
• First Posted: November 26, 2007
• Study Start: January 1, 2008
• Primary Completion: April 1, 2010
• Last Updated: December 24, 2013
• Results First Posted: May 17, 2011

Record last verified: 2012-07

Locations

GB (26); IT (18); BE (11); FI (10); DE (164); NL (4); LI (14); ES (24); TU (12); AU (18); HU (29); NO (12); RO (21); SL (8); PL (93); PT (10); FR (50); RU (92); CZ (29); BU (12); DK (10); IL (14); LA (13); UA (52)