Does Lung Impedance Correlate With Changes in BNP in Stable and Acutely Decompensated Heart Failure Patients?
IMPEDE-HF
1 other identifier
observational
100
1 country
6
Brief Summary
The purpose of this study is to determine whether there is a relationship between serial B-natriuretic peptide (BNP) and implantable device measured intrathoracic impedance in symptomatic and asymptomatic heart failure patients over a 1-year period. Furthermore, this study will establish whether implantable device measured intrathoracic impedance trends with the distance walked on a six-minute hall walk (6MHW), an exercise-based acute measure that has also been associated with heart failure clinical status.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Sep 2005
Typical duration for all trials
6 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2005
CompletedFirst Submitted
Initial submission to the registry
November 15, 2007
CompletedFirst Posted
Study publicly available on registry
November 19, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2009
CompletedNovember 19, 2007
November 1, 2007
November 15, 2007
November 15, 2007
Conditions
Keywords
Eligibility Criteria
Patients receiving with an implantable cardioverter defibrillator (ICD) with or without cardiac resynchronization therapy (CRT).
You may qualify if:
- Baseline BNP \> 80 pg/ml
- Meets current guidelines for ICD implantation with or without CRT
- Receiving a Medtronic InSync Sentry, Concerto, Virtuoso, or subsequently approved Medtronic ICD with the OptiVol feature.
- Walk \< 450 meters during 6 minute hall walk test
You may not qualify if:
- Less than 18 years of age
- Life expectancy \< 6 months
- History of non-compliance with clinic visits or study-related tasks which may decrease chance of completing of the study
- Physical disability which limits exercise
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Southern New Jersey Cardiac Specialistslead
- Medtroniccollaborator
Study Sites (6)
Glendale Memorial Hospital and Health Center
Glendale, California, United States
Southern New Jersey Cardiac Specialists
Voorhees Township, New Jersey, United States
St. Francis Hospital
Roslyn, New York, United States
Carolinas Healthcare System/The Sanger Clinic
Charlotte, North Carolina, United States
Mid State Cardiology Associates
Nashville, Tennessee, United States
Medical College of Wisconsin /Froedtert Hospital
Milwaukee, Wisconsin, United States
Related Publications (1)
Behnes M, Schmidberger M, Mashayekhi K, Vadala G, Moroni A, Guiterrez-Chico JL, Ayoub M, Christiansen EH, Pyxaras S, Bufe A, Krotz F, Schmitt A, Lau F, Reinhardt M, Forner J, Dudda J, Abel N, Hoepfner MK, Aubel C, Abumayyaleh M, Weidner K, Akin I, Schupp T. Coronary Chronic Total Occlusions Affect Long-Term Prognosis in Heart Failure With Mildly Reduced Ejection Fraction. J Am Heart Assoc. 2025 Sep 2;14(17):e042368. doi: 10.1161/JAHA.125.042368. Epub 2025 Aug 22.
PMID: 40847486DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
John Andriulli, DO
Southern New Jersey Cardiac Specialists
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
November 15, 2007
First Posted
November 19, 2007
Study Start
September 1, 2005
Study Completion
January 1, 2009
Last Updated
November 19, 2007
Record last verified: 2007-11