The Immune Function Intervention Trial
ImFIT
Physical Activity, Aging and Immune Function
2 other identifiers
interventional
150
1 country
1
Brief Summary
The purpose of the study is to examine whether cardiovascular exercise training improves immune responses to vaccination in previously sedentary older adults.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Aug 2002
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2002
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2006
CompletedFirst Submitted
Initial submission to the registry
October 24, 2007
CompletedFirst Posted
Study publicly available on registry
October 25, 2007
CompletedJanuary 27, 2009
January 1, 2009
3.9 years
October 24, 2007
January 23, 2009
Conditions
Outcome Measures
Primary Outcomes (1)
antibody responses to influenza and tetanus toxoid vaccination and delayed type hypersensitivity responses to fungal antigens
baseline, 6 and 10 months
Secondary Outcomes (2)
cardiovascular fitness
psychosocial outcomes
Study Arms (2)
1
EXPERIMENTALa 10-month moderate aerobic exercise training program
2
PLACEBO COMPARATORflexibility/balance control group
Interventions
Eligibility Criteria
You may qualify if:
- Ages 62-82
- Ability to participate in an exercise program
- Medical clearance by primary physician
- Non-smoker
- BMI 22-38
- Independently living
- Post-menopausal
- Sedentary for over 6 months
You may not qualify if:
- No recent history (within 6 months) of infection or vaccination
- History of systemic reactions to vaccination
- History of cancer
- Severe allergies/asthma requiring prescription medication
- Splenectomy or transplant patient
- Chronic Obstructive Pulmonary Disease (COPD)
- HIV positive
- Uncontrolled diabetes or hypertension
- Severe arthritis
- Mental illness or clinical depression
- Impaired cognitive status
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Illinois at Urbana-Champaign
Urbana, Illinois, 61801, United States
Related Publications (3)
Woods JA, Lowder TW, Keylock KT. Can exercise training improve immune function in the aged? Ann N Y Acad Sci. 2002 Apr;959:117-27. doi: 10.1111/j.1749-6632.2002.tb02088.x.
PMID: 11976191BACKGROUNDWoods JA, Ceddia MA, Wolters BW, Evans JK, Lu Q, McAuley E. Effects of 6 months of moderate aerobic exercise training on immune function in the elderly. Mech Ageing Dev. 1999 Jun 1;109(1):1-19. doi: 10.1016/s0047-6374(99)00014-7.
PMID: 10405985BACKGROUNDKohut ML, Cooper MM, Nickolaus MS, Russell DR, Cunnick JE. Exercise and psychosocial factors modulate immunity to influenza vaccine in elderly individuals. J Gerontol A Biol Sci Med Sci. 2002 Sep;57(9):M557-62. doi: 10.1093/gerona/57.9.m557.
PMID: 12196490BACKGROUND
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jeffrey A. Woods, PhD
University of Illinois at Urbana-Champaign
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- NIH
Study Record Dates
First Submitted
October 24, 2007
First Posted
October 25, 2007
Study Start
August 1, 2002
Primary Completion
July 1, 2006
Study Completion
July 1, 2006
Last Updated
January 27, 2009
Record last verified: 2009-01