Calibrating Imaging Techniques to Study Blood Flow

NCT00546091 | Completed

• 2 other identifiers: 08000108-CH-0001
• Study Type: observational
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

This study will explore the uses of three noninvasive imaging techniques-thermography, laser Doppler imaging, and multispectral imaging-to test the blood flow of healthy volunteers. By comparing these three techniques, researchers will be able to train these imaging systems to better evaluate skin types and blood flow. The study will also test computer programs that have been developed to correct for the effects of curvature and body hair on the images. Healthy volunteers must be older than 18 years of age and may not have had a history of malignant tumors, skin disease, or vascular disease. Participants will undergo the following procedures on an outpatient basis: Three different types of images taken of the participant s forearm

• Thermography infrared thermal imaging to map skin temperature
• Laser Doppler imaging low-powered laser imaging to map blood flow in the skin
• Multispectral imaging near-infrared light imaging to measure total blood flow and oxygen levels in the skin A reactive hyperemia experiment, in which multispectral images will be taken of the participant s forearm during and after the use of a blood pressure cuff A hair removal experiment, in which images will be collected of the participant s forearm in separate scans done before and after the hair is removed with a topical hair removal solution The entire series of exams will take approximately one hour to perform.

Conditions

Healthy Volunteers Only

Keywords

Imaging; Multi-Spectral Imaging; Thermography; Laser Doppler Imaging; Vasculature; Healthy Volunteer; HV

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18 years or greater.

You may not qualify if:

• Healthy volunteers with any skin disease.
• Past or present history of malignant tumors.
• Past or present hematologic abnormality of Hgb less than 9.0 gm/dl.
• Healthy volunteers with any past or present vein disease.
• Unable or unwilling to give informed consent.

Sponsors & Collaborators

• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Thorniley MS, Sinclair JS, Barnett NJ, Shurey CB, Green CJ. The use of near-infrared spectroscopy for assessing flap viability during reconstructive surgery. Br J Plast Surg. 1998 Apr;51(3):218-26. doi: 10.1054/bjps.1997.0145.

  PMID: 9664881 BACKGROUND

• Wolf M, Weber O, Keel M, Golay X, Scheidegger M, Bucher HU, Kollias S, Boesiger P, Banziger O. Comparison of cerebral blood volume measured by near infrared spectroscopy and contrast enhanced magnetic resonance imaging. Adv Exp Med Biol. 1999;471:767-73. doi: 10.1007/978-1-4615-4717-4_88.

  PMID: 10659212 BACKGROUND

• Essex TJ, Byrne PO. A laser Doppler scanner for imaging blood flow in skin. J Biomed Eng. 1991 May;13(3):189-94. doi: 10.1016/0141-5425(91)90125-q.

  PMID: 1870327 BACKGROUND

Study Officials

• Amir Gandjbakhche, Ph.D.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH

Study Record Dates

• First Submitted: October 17, 2007
• First Posted: October 18, 2007
• Study Start: October 15, 2007
• Study Completion: October 19, 2012
• Last Updated: October 6, 2017

Record last verified: 2012-10-19

Locations

US (1)