NCT00545909

Brief Summary

This 2 arm study will assess the impact of Bone Marker Feedback (BMF), using blood sampling and communication of the results at 2 months, on adherence to monthly Bonviva (150mg po) in women with post-menopausal osteoporosis. Patients will be randomized into either 1) a group which receives bone marker feedback or 2)a group which does not receive feedback on the results. The study will also assess patient satisfaction with treatment with once monthly Bonviva. The anticipated time on study treatment is 3-12 months, and the target sample size is 500+ individuals.

Trial Health

93
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
585

participants targeted

Target at P75+ for phase_4

Timeline
Completed

Started Mar 2006

Typical duration for phase_4

Geographic Reach
5 countries

57 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2006

Completed
1.6 years until next milestone

First Submitted

Initial submission to the registry

October 16, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 17, 2007

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2008

Completed
Last Updated

November 2, 2016

Status Verified

November 1, 2016

Enrollment Period

2.4 years

First QC Date

October 16, 2007

Last Update Submit

November 1, 2016

Conditions

Outcome Measures

Primary Outcomes (1)

  • Comparison of percentage of patients with >=83% adherence to Bonviva in feedback vs no feedback group

    6 months

Secondary Outcomes (2)

  • Patient satisfaction by OPSAT-Q and OPPS.

    6 months

  • Tolerability; SAEs.

    Throughout study

Study Arms (2)

1

EXPERIMENTAL
Drug: ibandronate [Bonviva/Boniva]

2

ACTIVE COMPARATOR
Drug: ibandronate [Bonviva/Boniva]

Interventions

150mg po monthly for 6 months (+ feedback)

1

Eligibility Criteria

Age55 Years - 85 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • ambulatory post-menopausal women with osteoporosis;
  • years of age;
  • eligible for bisphosphonate treatment;
  • naive to bisphosphonate therapy, or lapsed users (last bisphosphonate intake \> 6 months ago).

You may not qualify if:

  • inability to stand or sit in an upright position for at least 60 minutes;
  • inability to swallow a tablet whole;
  • hypersensitivity to bisphosphonates;
  • administration of any drug, or presence of active disease, known to influence bone metabolism;
  • uncorrected hypocalcemia or other bone disturbances of bone and mineral metabolism;
  • history of major upper gastrointestinal disease.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (57)

Unknown Facility

Bregenz, 6900, Austria

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Graz, 8036, Austria

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Innsbruck, 6020, Austria

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Linz, 4020, Austria

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Salzburg, 5020, Austria

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Vienna, 1021, Austria

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Vienna, 1060, Austria

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Vienna, 1100, Austria

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Vienna, 1130, Austria

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Vienna, 1150, Austria

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Vienna, 1160, Austria

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Vöcklabruck, 4840, Austria

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Aalst, 9300, Belgium

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Antwerp, 2018, Belgium

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Antwerp, 2020, Belgium

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Aye, 6900, Belgium

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Braine-l'Alleud, 1420, Belgium

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Bruges, 8000, Belgium

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Brussels, 1000, Belgium

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Brussels, 1020, Belgium

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Brussels, 1040, Belgium

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Brussels, 1180, Belgium

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Brussels, 1200, Belgium

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Charleroi, 6000, Belgium

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Dinant, 5500, Belgium

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Ekeren, 2180, Belgium

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Genk, 3600, Belgium

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Ghent, 9000, Belgium

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Godinne, 5530, Belgium

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Hasselt, 3500, Belgium

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Jambes, 5100, Belgium

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Knokke, 8300, Belgium

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Kortrijk, 8500, Belgium

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La Louvière, 7100, Belgium

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Liège, 4000, Belgium

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Liège, 4020, Belgium

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Mechelen, 2800, Belgium

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Merksem, 2170, Belgium

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Mons, 7000, Belgium

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Ostend, 8400, Belgium

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Roeselare, 8800, Belgium

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Sijsele, 8340, Belgium

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Tournai, 7500, Belgium

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Turnhout, 2300, Belgium

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Waremme, 4300, Belgium

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Wilrijk, 2610, Belgium

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Athens, 10682, Greece

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Athens, 16673, Greece

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Kifissia, 14561, Greece

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Larissa, 41110, Greece

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Thessaloniki, 54636, Greece

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Thessaloniki, 55132, Greece

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Thessaloniki, 56429, Greece

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Gorey, Ireland

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Tipperary, Ireland

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Luxembourg, 2311, Luxembourg

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Unknown Facility

Luxembourg, 2763, Luxembourg

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MeSH Terms

Conditions

Osteoporosis, Postmenopausal

Interventions

Ibandronic Acid

Condition Hierarchy (Ancestors)

OsteoporosisBone Diseases, MetabolicBone DiseasesMusculoskeletal DiseasesMetabolic DiseasesNutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

DiphosphonatesOrganophosphonatesOrganophosphorus CompoundsOrganic Chemicals

Study Officials

  • Clinical Trials

    Hoffmann-La Roche

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 16, 2007

First Posted

October 17, 2007

Study Start

March 1, 2006

Primary Completion

August 1, 2008

Study Completion

August 1, 2008

Last Updated

November 2, 2016

Record last verified: 2016-11

Locations