Fangshan / Family-based Ischemic Stroke Study In China
FISSIC
A Family-based Ischemic Stroke Study on Association and Interactions of Multi-pathway Genetic Polymorphisms
6 other identifiers
observational
1,500
1 country
1
Brief Summary
The exact etiology of ischemic stroke remains unclear, because multiple genetic predispositions and environmental risk factors may be involved, and their interactions dictate the complexity. Family-based studies provide unique features in design because of their robustness to population admixture and stratification. The Fangshan / Family-based Ischemic Stroke Study In China (FISSIC) program aims to conduct a genetic pedigree study of ischemic stroke in rural communities of China.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2005
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2005
CompletedFirst Submitted
Initial submission to the registry
September 21, 2007
CompletedFirst Posted
Study publicly available on registry
September 26, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2015
CompletedDecember 14, 2011
December 1, 2011
10.5 years
September 21, 2007
December 13, 2011
Conditions
Keywords
Eligibility Criteria
Ischemic stroke probands will be enrolled in two parts: incident cases from primary care clinic and prevalent cases from communities, and their family members will be recuited in communities.
You may qualify if:
- Diagnosis of at least one ischemic stroke confirmed by the study neurologist on the basis of history, medical records, and head imaging by CT or MRI;
- At least 18 years old by the time of enrolment in the study;
- At least one full sibling or parent alive in areas nearby;
- Written informed consent by the patient or surrogate.
You may not qualify if:
- Diagnosis of Transient Ischemic Attack (TIA) only;
- Diagnosis of vasospasm after subarachnoid hemorrhage;
- Diagnosis of some Mendelian disorders: CADASIL, Fabry disease, MELAS, or sickle cell anaemia;
- Diagnosis of iatrogenic ischemic stroke associated with a surgical / interventional procedure such as coronary artery bypass grafting, carotid endarterectomy, or heart valve surgery;
- Diagnosis of ischemic stroke associated with autoimmune condition or endocarditis.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Peking Universitylead
- National Natural Science Foundation of Chinacollaborator
- Ministry of Education, Chinacollaborator
- Ministry of Science and Technology of the People´s Republic of Chinacollaborator
Study Sites (1)
The First Hospital of Fangshan District
Beijing, 102400, China
Related Publications (1)
Tang X, Hu Y, Chen D, Zhan S, Zhang Z, Dou H. The Fangshan/Family-based Ischemic Stroke Study In China (FISSIC) protocol. BMC Med Genet. 2007 Sep 10;8:60. doi: 10.1186/1471-2350-8-60.
PMID: 17825112BACKGROUND
Biospecimen
serum, white cells
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Yonghua Hu, MD
Peking University School of Public Health
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- FAMILY BASED
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Executive Dean
Study Record Dates
First Submitted
September 21, 2007
First Posted
September 26, 2007
Study Start
June 1, 2005
Primary Completion
December 1, 2015
Study Completion
December 1, 2015
Last Updated
December 14, 2011
Record last verified: 2011-12