NCT00532363

Completed

Obesity and Asthma:a Specific Phenotype

Laval University Source

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Other study identifiers

Sponsor study identifier

HL-ORPA-1171

Study Type

observational

Actual enrollment (reported)

44

Locations

1 country

Sites

1

Timeline

Study Start

September 2005

Date type not reported

This date has not been verified as actual or estimated.

Primary Completion

Not reported

Date not reported

Study Completion

September 2010

Actual (reported)

Brief Summary

Clinicians frequently observed that obese women referred for severe asthma do not respond to treatment. These patients, despite the presence of wheezing, often have normal expiratory flows and normal or "borderline" airway responsiveness. It is therefore possible that this mode of presentation reflect a pseudo-asthmatic state for which clinical definition and characteristics and optimal management remain to be determined. The aim of this study was to study the pulmonary physiological and airway inflammatory characteristics and response to treatment of obese women considered to have clinically severe asthma in order to demonstrate that some of these patients have a phenotype that is not that of asthma.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: completed
Actual enrollment (reported): 44 participants
Study completion date: September 2010
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
September 2005
Date type not reported
This date has not been verified as actual or estimated.
First Submitted
September 18, 2007
Actual (reported)
First Posted
September 20, 2007
Actual (reported)
Study Completion
September 2010
Actual (reported)

Last Updated: February 22, 2012
Status Verified: February 2012
Last Update Submitted: February 20, 2012

Conditions

Asthma Obesity

Study Arms (2)

Obese asthmatics

Obese subjects with asthma (on inhaled corticosteroids)

Non obese asthmatics

Non obese subjects with asthma (on inhaled corticosteroids)

Eligibility Criteria

Age18 Years+

Sexfemale

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Subjects will be selected from advertisements in newspapers and from the hospital primary care asthma clinic and will be offered to participate to the study.

You may qualify if:

Will be women aged 18 years and over

Sponsors & Collaborators

Laval University
Otherlead

Study Sites (1)

Centre de Recherche, Hôpital Laval

Québec, Quebec, G1V 4G5, Canada

Related Publications (1)

Lessard A, Turcotte H, Cormier Y, Boulet LP. Obesity and asthma: a specific phenotype? Chest. 2008 Aug;134(2):317-323. doi: 10.1378/chest.07-2959. Epub 2008 Jul 18.
PMID: 18641097DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum plasma

MeSH Terms

Conditions

ObesityAsthma

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveLung DiseasesRespiratory HypersensitivityHypersensitivity, Immediate

Study Officials

Louis-Philippe Boulet, MD
Hôpital Laval
PRINCIPAL INVESTIGATOR

Enrollment

44 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: CROSS SECTIONAL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: MD, FRCPC, FCCP

Study Record Dates

First Submitted

September 18, 2007

First Posted

September 20, 2007

Study Start

September 2005

Date type not reported

This date has not been verified as actual or estimated.

Will be in good health apart from asthma or obesity as determined by history and physical examination (No other condition that could influence the proposed tests).

All will be non smokers or ex-smokers for more than six months with a smoking history of no more than 10 pack- years (i.e., one pack per day or its equivalent for 10 years.)

Subjects will have a physician's made diagnosis of severe asthma and treated with corticosteroids.

You may not qualify if:

Subjects who are, in the opinion of the investigator, mentally or legally incapacitated thus preventing informed consent from being obtained.
Subjects having a co-existing illness that precludes them from the trial.
Pregnancy or lactation
Contraindication to the prednisone treatment.

Contact the study team to confirm eligibility.

Hypersensitivity

Immune System Diseases

Study Completion

September 2010

Actual (reported)

Last Updated

February 22, 2012

Record last verified: 2012-02

Source record

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Source: ClinicalTrials.gov.

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Registry identifier: NCT00532363
Data provider: ClinicalTrials.gov
Source updated: 2012-02-22
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:39:01 UTC

Locations

CA(1)

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Study Completion

Conditions

Study Arms (2)

Obese asthmatics

Non obese asthmatics

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations