Obesity and Asthma:a Specific Phenotype

NCT00532363 | Completed

• 1 other identifier: HL-ORPA-1171
• Study Type: observational
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

Clinicians frequently observed that obese women referred for severe asthma do not respond to treatment. These patients, despite the presence of wheezing, often have normal expiratory flows and normal or "borderline" airway responsiveness. It is therefore possible that this mode of presentation reflect a pseudo-asthmatic state for which clinical definition and characteristics and optimal management remain to be determined. The aim of this study was to study the pulmonary physiological and airway inflammatory characteristics and response to treatment of obese women considered to have clinically severe asthma in order to demonstrate that some of these patients have a phenotype that is not that of asthma.

Conditions

Obesity; Asthma

Study Arms (2)

Obese asthmatics

Obese subjects with asthma (on inhaled corticosteroids)

Non obese asthmatics

Non obese subjects with asthma (on inhaled corticosteroids)

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects will be selected from advertisements in newspapers and from the hospital primary care asthma clinic and will be offered to participate to the study.

You may qualify if:

• Will be women aged 18 years and over
• Will be in good health apart from asthma or obesity as determined by history and physical examination (No other condition that could influence the proposed tests).
• All will be non smokers or ex-smokers for more than six months with a smoking history of no more than 10 pack- years (i.e., one pack per day or its equivalent for 10 years.)
• Subjects will have a physician's made diagnosis of severe asthma and treated with corticosteroids.

You may not qualify if:

• Subjects who are, in the opinion of the investigator, mentally or legally incapacitated thus preventing informed consent from being obtained.
• Subjects having a co-existing illness that precludes them from the trial.
• Pregnancy or lactation
• Contraindication to the prednisone treatment.

Sponsors & Collaborators

• Laval University: lead

Study Sites (1)

Centre de Recherche, Hôpital Laval

Québec, Quebec, G1V 4G5, Canada

Location

Related Publications (1)

• Lessard A, Turcotte H, Cormier Y, Boulet LP. Obesity and asthma: a specific phenotype? Chest. 2008 Aug;134(2):317-323. doi: 10.1378/chest.07-2959. Epub 2008 Jul 18.

  PMID: 18641097 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum plasma

MeSH Terms

Conditions

Obesity; Asthma

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Louis-Philippe Boulet, MD

  Hôpital Laval

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, FRCPC, FCCP

Study Record Dates

• First Submitted: September 18, 2007
• First Posted: September 20, 2007
• Study Start: September 1, 2005
• Study Completion: September 1, 2010
• Last Updated: February 22, 2012

Record last verified: 2012-02

Locations

CA (1)