NCT00523835|Completed
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Sponsor study identifier
observational
140
1 country
1
Study Start
April 2002
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
November 2004
Actual (reported)Klinefelter syndrome (KS) is the most common sex-chromosome disorder with a prevalence of one in 660 men and is a frequent cause of hypogonadism and infertility. It is caused by the presence of extra X-chromosomes, the most common karyotype being 47,XXY. The phenotype is variable, but the most constant finding is small hyalinized testes, hypergonadotrophic hypogonadism, infertility, eunuchoid body proportion, increased height and learning disabilities. Klinefelter syndrome has been associated with increased prevalence of diabetes, osteoporosis and cardiovascular diseases but the pathogenesis is unknown. Accordingly the aim of the study was to investigate measures of body composition, insulin sensitivity, bone mineral density, echocardiography, as well as biochemical markers of endocrine, metabolic and bone function in KS and an age-matched control group.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 2004
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 2002
Date type not reportedThis date has not been verified as actual or estimated.
November 2004
Actual (reported)August 31, 2007
Actual (reported)September 3, 2007
Actual (reported)Patients with Klinefelter syndrome verified by chromosome analysis
Normal men Age matched to KS patients
Medical department M, Endocrinology and Diabetes, and Medical Research Laboratories, Clinical Institute, Aarhus University Hospital
Aarhus, 8000, Denmark
Bojesen A, Kristensen K, Birkebaek NH, Fedder J, Mosekilde L, Bennett P, Laurberg P, Frystyk J, Flyvbjerg A, Christiansen JS, Gravholt CH. The metabolic syndrome is frequent in Klinefelter's syndrome and is associated with abdominal obesity and hypogonadism. Diabetes Care. 2006 Jul;29(7):1591-8. doi: 10.2337/dc06-0145.
Overvad S, Bay K, Bojesen A, Gravholt CH. Low INSL3 in Klinefelter syndrome is related to osteocalcin, testosterone treatment and body composition, as well as measures of the hypothalamic-pituitary-gonadal axis. Andrology. 2014 May;2(3):421-7. doi: 10.1111/j.2047-2927.2014.00204.x. Epub 2014 Mar 21.
Jens S. Christiansen, Professor
Medical department M, Endocrinology and Diabetes, and Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Denmark
Anders B Bojesen, MD, PhD
Medical department M, Endocrinology and Diabetes, and Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Denmark
Claus H Gravholt, MD, DMsc, PhD
Medical department M, Endocrinology and Diabetes, and Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Denmark
First Submitted
August 31, 2007
First Posted
September 3, 2007
Study Start
April 2002
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
November 2004
Actual (reported)Physiologic Interactions Between the Adrenal- and the Parathyroid Glands
Dairy Lipids, Proteins, and the Metabolic Syndrome - "DairyHealth"
Contact the study team to confirm eligibility.
Last Updated
September 3, 2007
Record last verified: 2007-08
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Source: ClinicalTrials.gov.
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