SARS Survivor Evaluations
Immune Responses, Transmission and Nucleotide Polymorphisms in Families With SARS Virus Infections
1 other identifier
observational
N/A
1 country
2
Brief Summary
The purpose of this study is to understand how severe acute respiratory syndrome (SARS) spreads within families, if significant disease resulted, and how the body responds to SARS. The study will also explore the affects of SARS on genetics and the immune system (the body system that fights disease). Up to 1000 people residing in Beijing, China may be involved in this study. Adult survivors of SARS (numbering 200) and their family members including children age 4 and up will be asked to participate in the study. The study will recruit an additional 200 persons, who will be matched with SARs survivors of similar age, gender, health status, and housing/work location, and recruited as comparators. Blood will be taken from all volunteers and tested for the presence of SARS antibodies (proteins made by the body's immune system in response to something that can cause infection). Health and clinic/hospital visit records may be reviewed.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
2 active sites
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Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 30, 2007
CompletedFirst Posted
Study publicly available on registry
August 31, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2011
CompletedApril 29, 2013
April 1, 2011
August 30, 2007
April 25, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Positive serology, SARS CoV
at time of assay
Study Arms (3)
HCWs
Who may/may not have contact with SARS patients
Family/close contacts
No illness but household/close contact
SARS subjects
Diagnosed with active disease
Eligibility Criteria
Adult (\> 18 yo) SARS survivors and family members. Adult matched controls
You may qualify if:
- Severe Acute Respiratory Syndrome (SARS) Survivors and Controls:
- An adult (\>= 18 years of age) proven in hospital/laboratory records to have had SARS as defined by the World Health Organization
- A control matched for age, gender and health status similar to a SARS survivor and with a possible SARS exposure (healthcare personnel).
- Granting informed consent
- Family Members of SARS Survivors:
- Family members currently age 4 or older who were living in a household with the SARS survivor study case at the time of SARS occurrence.
- Informed consent granted by subject or parent if child is less than 18 years old.
You may not qualify if:
- Severe Acute Respiratory Syndrome (SARS) Survivors and Controls:
- Presence of an acute illness.
- Hemoglobin below normal range for gender and age.
- Current pregnancy or possible pregnancy (by history).
- Family Members of SARS Survivors:
- \. Current pregnancy or possible pregnancy (by history).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Beijing Ditan Hospital
Beijing, Beijing Municipality, 100011, China
Beijing You'An Hospital
Beijing, Beijing Municipality, 100069, China
Biospecimen
Sera, PBMCs
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- FAMILY BASED
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- NIH
Study Record Dates
First Submitted
August 30, 2007
First Posted
August 31, 2007
Primary Completion
June 1, 2011
Study Completion
June 1, 2011
Last Updated
April 29, 2013
Record last verified: 2011-04