Epidemiologic Multicenter Study on Mechanical Ventilation Management in Children With Acute Lung Injury
PALIVE1
1 other identifier
observational
N/A
12 countries
58
Brief Summary
PALIVE 1 is an observational multicenter study on mechanical ventilation strategies used in children with an acute lung injury (ALI). The objective of the study is to describe mechanical ventilation strategies in children with an ALI. Our hypothesis is that daily clinical practice is heterogenous among pediatric intensivists as few pediatric data exists on optimal mechanical ventilation strategies in this group of patients. Furthermore, different strategies may affect patient outcome.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Jun 2007
Shorter than P25 for all trials
58 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2007
CompletedFirst Submitted
Initial submission to the registry
August 24, 2007
CompletedFirst Posted
Study publicly available on registry
August 28, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2007
CompletedMay 22, 2008
May 1, 2008
August 24, 2007
May 21, 2008
Conditions
Eligibility Criteria
You may qualify if:
- Child on invasive mechanical ventilation administered through an endotracheal tube or a tracheostomy tube, or on non-invasive mechanical ventilation administered through a nasal or facial mask or a nasal canula or helmet at 9 a.m. on the day of the study.
- Presence of ALI as estimated by the attending physician:
- Onset of hypoxemia was acute
- Bilateral infiltrates on chest X-Ray
- No clinical evidence of congestive heart failure
- Sustained hypoxemia defined as:
- PaO2(mmHg)/FiO2 ratio ≤ 300 or PaO2(kPa)/FiO2 ≤ 40
- If no arterial canula or no arterial blood gas:
- SpO2/FiO2 ≤ 320 with SpO2 \< 0.98 (10)
You may not qualify if:
- Post conceptional age \< 42 weeks
- Age \> 18 years
- Non-corrected cyanotic congenital heart disease or evidence of extra-pulmonary right to left shunt
- Withdrawal/withholding of care
- Brain death
- No consent, if required
- Patient on ECMO
- Already included in this study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (58)
Children's Hospital Los Angeles
Los Angeles, California, United States
Children's Hospital at Oakland
Oakland, California, United States
The Children's Hospital
Denver, Colorado, United States
Connecticut Children's Medical Center
Hartford, Connecticut, United States
Miami Children's Hospital
Miami, Florida, United States
Children's Memorial Hospital
Chicago, Illinois, United States
Riley Hospital for Children
Indianapolis, Indiana, United States
Kentucky Children's Hospital
Lexington, Kentucky, United States
UMAss Memorial Medical Center
Worchester, Massachusetts, United States
Children's Mercy Hospital
Kansas City, Missouri, United States
Children's Hospital
Omaha, Nebraska, United States
Nebraska Medical Center
Omaha, Nebraska, United States
Darmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States
New York Presbyterian Hospital
New York, New York, United States
Duke University Medical Center
Durham, North Carolina, United States
Penn State Children's Hospital
Hershey, Pennsylvania, United States
The Children's hospital Philadelphia
Philadelphia, Pennsylvania, United States
Children's Hospital of Austin
Austin, Texas, United States
Texas Childrens Hospital
Houston, Texas, United States
Children's Hospital of Wisconsin
Milwaukee, Wisconsin, United States
Akademisches Lehrkrankenhaus
Feldkirch, Austria
Medical University of Vienna
Vienna, Austria
Paola Childrens Hospital
Antwerp, Belgium
Cliniques universitaires Saint-Luc
Brussels, Belgium
Hôpital SteJustine
Montreal, Quebec, Canada
Montreal Children' Hospital
Montreal, Quebec, Canada
Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec, Canada
Stollery Children's Hospital
Edmonton, Canada
McMaster Children's Hospital
Hamilton, Canada
Children's Hospital of Western Ontario
London, Canada
Centre Hospitalier Universitaire de Quebec
Québec, Canada
BC Children's Hospital
Vancouver, Canada
CHU Lille
Lille, France
CHU Nantes
Nantes, France
Hôpital Robert-Debré
Paris, France
Necker
Paris, France
CHU Pontchaillou
Rennes, France
University Clinic Frankfurt
Frankfurt, Germany
Universitätsklinikum Mannheim
Mannheim, Germany
Kinderzentrum im Klinikum Nürnberg
Nuremberg, Germany
Children's Hospital StAugustin
Sankt Augustin, Germany
University Children's Hospital
Tuebringen, Germany
Ospedali riuniti di Bergamo
Bergamo, Italy
Padua University Hospital
Padua, Italy
Azienda Ospedaliera di Verona
Verona, Italy
The Wilhelmina Children's Hospital
Utrecht, Netherlands
Hospital Sant Joan de Déu-Hospital Clinic
Barcelona, Spain
Cruces Hospital
Bilbao, Spain
General University Hospital Gregorio Marañón
Madrid, Spain
Hospital Universitario Central de Asturias
Oveido, Spain
Hospital universitario de Salamanca
Salamanca, Spain
Hospital Clínico Universitario de Santiago de Compostela
Santiago de Compostela, Spain
Hospital Infantil La Fe
Valencia, Spain
The Queen Silvia Children's Hospital
Gothenburg, Sweden
Astrid Lindgren Children's Hospital
Stockholm, Sweden
Children's Hospital
Geneva, Switzerland
Centre Hospitalier Universitaire Vaudois
Lausanne, Switzerland
Bristol Children's Hospital
Bristol, United Kingdom
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Philippe Jouvet, MD
St. Justine's Hospital
Study Design
- Study Type
- observational
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
August 24, 2007
First Posted
August 28, 2007
Study Start
June 1, 2007
Study Completion
November 1, 2007
Last Updated
May 22, 2008
Record last verified: 2008-05