Epidemiology of Fluoroquinolone Resistance in Human Commensal Flora in Patients Hospitalised in Medical Wards

NCT00520715 | Completed

• 1 other identifier: FQ/EPI
• Study Type: observational
• Target: 640
• Locations: 1 country
• Sites: 1

Brief Summary

Emergence of bacterial resistance to antibiotics, which is a major public health issue, appears to involve predominantly commensal flora. No data exists concerning risk factors for the carriage of fluoroquinolone resistant bacteria in the flora of hospitalised patients. We will conduct a prospective open study including all unselected patients hospitalised in medical wards of one hospital. Nasal, pharyngeal and rectal swabs will be performed upon admission as well as a review of potential risk factors, after patient's information and acceptance. Resistance testing aiming 3 pathogens (Staphylococcus, Streptococcus and E. coli) will be performed on all specimens, and a case control study will compare risk factors from the resistant and non-resistant groups, for each pathogen. A thousand patients should be included in a year's time. This work could help understand risk factors involved in the carriage of fluoroquinolone resistant pathogens, potentially responsible for invasive infections and inter-patient transmission of resistance. Limiting bacterial resistance and transmission is a goal that can be successfully undertaken only if resistance mechanisms, but also risk factors of acquiring resistant bacteria are better understood.

Conditions

Colonization; Multi Drug Resistant Bacteria; Hospitalized Patients

Keywords

fluoroquinolone resistance; commensal flora; carriage

Study Arms (1)

Patients at hospital admission

Patients at hospital admission in medical wards on our tertiray care hospital (Hôpital Beaujon, Clichy, France).

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

adults patients at hospital admission hospital stay \>24 hours informed consent required

You may qualify if:

• all adult patients admitted to the internal medicine, oncology, cardiology and geriatric unit of Beaujon Hospital, Clichy, France.
• patient agreement

You may not qualify if:

• Age \< 18
• patient refusal or incapable

Sponsors & Collaborators

• Association Pour le Recherche en Infectiologie et en Médecine Interne: lead
• Pr Bruno Fantin: collaborator

Study Sites (1)

Hôpital Beaujon

Clichy, Île-de-France Region, 92110, France

Location

Related Publications (1)

• de Lastours V, Chau F, Tubach F, Pasquet B, Ruppe E, Fantin B. Independent behavior of commensal flora for carriage of fluoroquinolone-resistant bacteria in patients at admission. Antimicrob Agents Chemother. 2010 Dec;54(12):5193-200. doi: 10.1128/AAC.00823-10. Epub 2010 Sep 27.

  PMID: 20876373 DERIVED

Study Officials

• Victoire de Lastours, MD

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: July 11, 2007
• First Posted: August 24, 2007
• Study Start: June 1, 2007
• Primary Completion: November 1, 2007
• Study Completion: December 1, 2007
• Last Updated: June 23, 2015

Record last verified: 2015-06

Locations

FR (1)