T2* in Transfusion Dependant Anemia, MI, LVF, Normal Patients

NCT00520559 | Completed

• 1 other identifier: 07/MRE04/32
• Study Type: observational
• Target: 652
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to provide accurate prognostic data linking cardiac complications to myocardial T2\* values (A measure of iron levels in the heart using MRI)in patients predisposed to heart iron overload.

Conditions

Thalassemia

Outcome Measures

Primary Outcomes (2)

• Heart Failure

  Ejection fraction

  1yr

• Arrhythmia

  ECG

  1yr

Study Arms (1)

Thalassemia

Eligibility Criteria

• Age: 18 Years - 77 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Please note that the age range detailed above refers to the normal group (63 patients): the study article provided by the study team to complete this record only provides a mean age range for the 39 Left Ventricular Dysfunction Group (50.1 +/- 14.0 years) and 24 Septal Infarction Group (58.6 +/- 13.9).

You may qualify if:

• Thalassaemia Major
• Patient must have had a cardiac MRI scan between 1999 and 2006

You may not qualify if:

• Other structural heart disease such as valvular abnormalities, MI, congenital heart disease

Sponsors & Collaborators

• Imperial College London: lead

Related Publications (3)

• Kirk P, Roughton M, Porter JB, Walker JM, Tanner MA, Patel J, Wu D, Taylor J, Westwood MA, Anderson LJ, Pennell DJ. Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation. 2009 Nov 17;120(20):1961-8. doi: 10.1161/CIRCULATIONAHA.109.874487. Epub 2009 Oct 2.

  PMID: 19801505 RESULT

• Kirk P, Sheppard M, Carpenter JP, Anderson L, He T, St Pierre T, Galanello R, Catani G, Wood J, Fucharoen S, Porter JB, Walker JM, Forni GL, Pennell DJ. Post-mortem study of the association between cardiac iron and fibrosis in transfusion dependent anaemia. J Cardiovasc Magn Reson. 2017 Mar 27;19(1):36. doi: 10.1186/s12968-017-0349-3.

  PMID: 28343449 DERIVED

• Kirk P, He T, Anderson LJ, Roughton M, Tanner MA, Lam WW, Au WY, Chu WC, Chan G, Galanello R, Matta G, Fogel M, Cohen AR, Tan RS, Chen K, Ng I, Lai A, Fucharoen S, Laothamata J, Chuncharunee S, Jongjirasiri S, Firmin DN, Smith GC, Pennell DJ. International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers. J Magn Reson Imaging. 2010 Aug;32(2):315-9. doi: 10.1002/jmri.22245.

  PMID: 20677256 DERIVED

MeSH Terms

Conditions

Thalassemia

Condition Hierarchy (Ancestors)

Anemia, Hemolytic, Congenital; Anemia, Hemolytic; Anemia; Hematologic Diseases; Hemic and Lymphatic Diseases; Hemoglobinopathies; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Dudley Pennell, MA, MD

  Imperial College London

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: August 23, 2007
• First Posted: August 24, 2007
• Study Start: January 1, 2007
• Study Completion: August 1, 2007
• Last Updated: February 14, 2024

Record last verified: 2024-02