Identifying Genetic Determinants of Eczema Herpeticum and Other Viral Infections in Individuals With Atopic Dermatitis

NCT00515047 | Completed DMC

• 2 other identifiers: DAIT ADVN GENE 04HHSN266200400033
• Study Type: observational
• Target: 900
• Locations: 1 country
• Sites: 7

Brief Summary

People with atopic dermatitis (AD), or eczema, are susceptible to skin infections and inflammations. Some individuals with AD develop a condition known as eczema herpeticum (EH) following exposure to the herpes simplex virus (HSV). The purpose of this study is to identify the genetic determinants that lead people with AD to develop EH and similar conditions caused by other viruses.

Conditions

Atopic Dermatitis

Keywords

Atopic Dermatitis; Eczema; Eczema Herpeticum; Molluscum Contagiousum; Herpes Simplex; Vaccinia

Outcome Measures

Primary Outcomes (1)

• Identification of variants/haplotypes in EH-associated genes and characterization of frequencies of variants in priority candidate genes for EH

  Throughout Study

Secondary Outcomes (1)

• Identification and prioritization of novel genes induced in response to viral infection (HSV/Vaccinia and MCV) in AD participants and relevant control groups

  Throughout Study

Study Arms (3)

Eczema Herpeticum (EH)

Participants with AD who currently have or have had EH

Non-EH

Participants with AD who do not have and have never had EH

Healthy Controls

Healthy participants without a history of AD

Eligibility Criteria

• Age: 8 Months - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

African-American, Caucasian, and Non-Hispanic people ages 8 months to 80 years

You may qualify if:

• Enrollment in ADVN Biomarker Registry Study
• Non-Hispanic and only African American or only Caucasian race
• Parent or guardian willing to provide informed consent, if necessary

You may not qualify if:

• History of any systemic illness, excluding AD
• Participation of a first degree relative already enrolled in the genotyping study unless the subject in question fulfills the diagnostic criteria for ADEH+. More information on this criterion can be found in the protocol.

Sponsors & Collaborators

• National Institute of Allergy and Infectious Diseases (NIAID): lead

Study Sites (7)

University of California at San Diego

La Jolla, California, 92037, United States

Location

National Jewish Health

Denver, Colorado, 80206, United States

Location

Children's Memorial Hospital

Chicago, Illinois, United States

Location

Northwestern University

Chicago, Illinois, United States

Location

Children's Hospital Boston

Boston, Massachusetts, 02115, United States

Location

University of Rochester Medical Center

Rochester, New York, 14642, United States

Location

Oregon Health & Sciences University

Portland, Oregon, 97239, United States

Location

Related Publications (6)

• Baker BS. The role of microorganisms in atopic dermatitis. Clin Exp Immunol. 2006 Apr;144(1):1-9. doi: 10.1111/j.1365-2249.2005.02980.x.

  PMID: 16542358 BACKGROUND

• Kim BE, Leung DY, Streib JE, Kisich K, Boguniewicz M, Hamid QA, Howell MD. Macrophage inflammatory protein 3alpha deficiency in atopic dermatitis skin and role in innate immune response to vaccinia virus. J Allergy Clin Immunol. 2007 Feb;119(2):457-63. doi: 10.1016/j.jaci.2006.10.005. Epub 2006 Dec 4.

  PMID: 17141855 BACKGROUND

• Porter CD, Muhlemann MF, Cream JJ, Archard LC. Molluscum contagiosum: characterization of viral DNA and clinical features. Epidemiol Infect. 1987 Oct;99(2):563-6. doi: 10.1017/s0950268800068072.

  PMID: 2824227 BACKGROUND

• Umene K, Yoshida M, Sakaoka H. Comparison of the association with eczema herpeticum in the two predominant genotypes of herpes simplex virus type 1. J Med Virol. 1996 Aug;49(4):329-32. doi: 10.1002/(SICI)1096-9071(199608)49:43.0.CO;2-5.

  PMID: 8877767 BACKGROUND

• Gao PS, Leung DY, Rafaels NM, Boguniewicz M, Hand T, Gao L, Hata TR, Schneider LC, Hanifin JM, Beaty TH, Beck LA, Weinberg A, Barnes KC. Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum. J Invest Dermatol. 2012 Mar;132(3 Pt 1):650-7. doi: 10.1038/jid.2011.374. Epub 2011 Nov 24.

  PMID: 22113474 RESULT

• Gao PS, Rafaels NM, Mu D, Hand T, Murray T, Boguniewicz M, Hata T, Schneider L, Hanifin JM, Gallo RL, Gao L, Beaty TH, Beck LA, Leung DY, Barnes KC. Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum. J Allergy Clin Immunol. 2010 Jun;125(6):1403-1407.e4. doi: 10.1016/j.jaci.2010.03.016. Epub 2010 May 13. No abstract available.

  PMID: 20466416 RESULT

Related Links

• Click here for more information about the Atopic Dermatitis and Vaccinia Network

Biospecimen

Retention: SAMPLES WITH DNA

Skin scrapings and blood collection may occur

MeSH Terms

Conditions

Dermatitis, Atopic; Eczema; Kaposi Varicelliform Eruption; Herpes Simplex; Vaccinia

Condition Hierarchy (Ancestors)

Skin Diseases, Genetic; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Eczematous; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Herpesviridae Infections; DNA Virus Infections; Virus Diseases; Infections; Skin Diseases, Viral; Skin Diseases, Infectious; Poxviridae Infections

Study Officials

• Lisa Beck, MD

  University of Rochester

  PRINCIPAL INVESTIGATOR

• Kathleen Barnes, PhD

  Johns Hopkins Allergy and Asthma Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 10, 2007
• First Posted: August 13, 2007
• Study Start: May 1, 2006
• Primary Completion: January 1, 2011
• Study Completion: January 1, 2011
• Last Updated: April 2, 2014

Record last verified: 2014-04

Locations

US (7)