Postoperative Cognitive Dysfunction in Geriatric Patients
1 other identifier
observational
280
1 country
1
Brief Summary
Geriatric patients have a high risk of developing postoperative cognitive deficits. Hypothetical causes are insufficient intraoperative cerebral perfusion or drugs that are administered in the perioperative setting. This study will investigate the role of these two factors in patients aged 65 or older undergoing elective surgical procedures under general aesthesia. Non-invasive techniques will be used to monitor intraoperative cerebral perfusion and anticholinergic activity in the patient's blood is determined. Data will be compared to those of a young (20-40 year old) group of patients undergoing elective surgical procedures using an identical anesthetic technique. A second control group of healthy volunteers older than 65 will be investigated to quantify practice effects with repeated testing of cognitive functions.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 2007
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2007
CompletedFirst Submitted
Initial submission to the registry
August 6, 2007
CompletedFirst Posted
Study publicly available on registry
August 7, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2012
CompletedOctober 16, 2015
October 1, 2015
4.6 years
August 6, 2007
October 14, 2015
Conditions
Outcome Measures
Primary Outcomes (1)
Change in cognitive function due to surgery under general aesthesia
cognitive function measured by Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neurological test battery
cognitive function measured prior to and after surgery
Study Arms (3)
Case
Patients aged 65 or older
Control
Patients aged 20 to 40
Control 2
Healthy volunteers aged 65 or older
Eligibility Criteria
Patients undergoing elective major surgery under general anesthesia
You may qualify if:
- Elective surgical procedure under general anaesthesia
You may not qualify if:
- History of cerebrovascular disease
- Mini Mental status \<23
- Cardiac surgery
- Neurosurgery
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Anaesthesia, University Hospital Basel
Basel, Canton of Basel-City, 4031, Switzerland
Related Publications (1)
Goettel N, Patet C, Rossi A, Burkhart CS, Czosnyka M, Strebel SP, Steiner LA. Monitoring of cerebral blood flow autoregulation in adults undergoing sevoflurane anesthesia: a prospective cohort study of two age groups. J Clin Monit Comput. 2016 Jun;30(3):255-64. doi: 10.1007/s10877-015-9754-z. Epub 2015 Aug 19.
PMID: 26285741DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Luzius A Steiner, MD, Prof.
Department of Anaesthesia, University Hospital Basel
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 6, 2007
First Posted
August 7, 2007
Study Start
July 1, 2007
Primary Completion
February 1, 2012
Study Completion
February 1, 2012
Last Updated
October 16, 2015
Record last verified: 2015-10