NCT00511758

Brief Summary

The overall objective of this study is to evaluate whether polarized or green filtered digital imaging can assist clinicians to screen for premalignant lesions in the cervix. The specific aims of the study are:

  • To compare polarized and green filtered digital images of the cervix, to standard white light images, colposcopic evaluation and to pathologic analysis of biopsied tissue.
  • To develop algorithms to discriminate between normal and abnormal tissue based on digital images of the cervix.
  • To analyze digital images to determine which types of optical information yield the most diagnostically useful data.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
3

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Jun 2007

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2007

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

August 2, 2007

Completed
4 days until next milestone

First Posted

Study publicly available on registry

August 6, 2007

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2009

Completed
Last Updated

August 1, 2012

Status Verified

July 1, 2012

Enrollment Period

1.9 years

First QC Date

August 2, 2007

Last Update Submit

July 31, 2012

Conditions

Keywords

Cervical DysplasiaDigital ImagingColposcopyCervix

Outcome Measures

Primary Outcomes (1)

  • Evaluate whether a digital camera image can work as well as colposcopy at detecting precancerous tissue.

    2 Year

Study Arms (1)

Digital Imaging Device

Patients with a diagnosis of cervical dysplasia that are scheduled for a colposcopy.

Procedure: Digital Imaging

Interventions

Images of the cervix will be taken using different types of light and compared with the colposcopy procedure.

Digital Imaging Device

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with a diagnosis of cervical dysplasia that are scheduled for a colposcopy.

You may qualify if:

  • Patients 18 years or older who are referred to the University of Texas MD Anderson Cancer Center Colposcopy Clinic for colposcopy are eligible for this study.
  • Patients must sign an informed consent indicating awareness of the investigational nature of this study.

You may not qualify if:

  • Patients who are pregnant are not eligible for this study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

U.T.M.D. Anderson Cancer Center

Houston, Texas, 77030, United States

Location

Related Links

MeSH Terms

Conditions

Uterine Cervical Dysplasia

Interventions

Quantitative Phase Imaging

Condition Hierarchy (Ancestors)

Precancerous ConditionsNeoplasmsUterine Cervical DiseasesUterine DiseasesGenital Diseases, FemaleFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesGenital Diseases

Intervention Hierarchy (Ancestors)

Microscopy, InterferenceMicroscopyDiagnostic ImagingDiagnostic Techniques and ProceduresDiagnosisInvestigative Techniques

Study Officials

  • Michele Follen, MD, PhD

    M.D. Anderson Cancer Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 2, 2007

First Posted

August 6, 2007

Study Start

June 1, 2007

Primary Completion

May 1, 2009

Study Completion

May 1, 2009

Last Updated

August 1, 2012

Record last verified: 2012-07

Locations