Epigenetic Markers in Growth Restricted Human Pregnancies: a Case-controlled Study

NCT00510380 | Completed DMC

• 1 other identifier: SIG/07072
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This study is carried out to discover if a baby with restricted growth in the womb is subject to specific fetal programming which predisposes to the metabolic syndrome(diabetes,hypertension,heart disease) in adulthood.We have elected to first study this condition in Chinese population in Singapore with the eventual plan of studying all ethnic groups. This is important for understanding the molecular basis of adult-onset disease such as diabetes, identifying children at risk of developing this disease in future and targeting specific strategies for intervention and disease prevention. Intrauterine fetal programming is effected through epigenetic changes similar to those previously identified in animal studies. The epigenetic markers can be found in growth restricted Chinese pregnancies in the local population.

Conditions

Fetal Growth Retardation

Study Arms (2)

growth-restricted Chinese pregnancies

appropriately-grown Chinese pregnancies

Eligibility Criteria

• Age: 21 Years - 50 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Babies from Chinese women with single pregnancies

You may qualify if:

• Chinese women,
• Singleton pregnancies,
• fetal growth restriction diagnosed clinically and by ultrasound parameters,
• Normally grown fetuses by clinical and ultrasound criteria

You may not qualify if:

• Non-Chinese women
• Multiple pregnancies
• Co-existing antenatal complications including sever pre-eclampsia

Sponsors & Collaborators

• National University Hospital, Singapore: lead

Study Sites (1)

National University Hospital

Singapore, 119074, Singapore

Location

MeSH Terms

Conditions

Fetal Growth Retardation

Condition Hierarchy (Ancestors)

Fetal Diseases; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Growth Disorders; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Yap Seng Chong, MBBS

  National University Hospital, Singapore

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: August 1, 2007
• First Posted: August 2, 2007
• Study Start: April 1, 2007
• Study Completion: April 1, 2009
• Last Updated: September 21, 2009

Record last verified: 2009-09

Locations

SG (1)