Prognosis in Asymptomatic Mitral Regurgitation (PAMIR) Study
1 other identifier
observational
200
2 countries
6
Brief Summary
The purpose of this study is to determine if the use of BNP/NT-proBNP levels in the detection of early left ventricular dysfunction and damage may improve the timing of cardiac surgery and therefore the long-term management of asymptomatic patients with severe mitral regurgitation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2006
Longer than P75 for all trials
6 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2006
CompletedFirst Submitted
Initial submission to the registry
July 30, 2007
CompletedFirst Posted
Study publicly available on registry
July 31, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2023
CompletedFebruary 28, 2025
February 1, 2025
17.7 years
July 30, 2007
February 25, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Composite of congestive heart failure, decompensated heart failure and valve surgery
Elevated BNP/NT-proBNP levels reflect early left and right ventricular dysfunction indicating imminent congestive heart failure and cardiac decompensation, and call for surgical intervention.
360 days
Composite of congestive heart failure, decompensated heart failure and valve surgery
Elevated BNP/NT-proBNP levels reflect early left and right ventricular dysfunction indicating imminent congestive heart failure and cardiac decompensation, and call for surgical intervention.
720 days
Eligibility Criteria
All patients admitted to the participating centers
You may qualify if:
- Patients with severe isolated mitral regurgitation due to valvular disease
You may not qualify if:
- Missing written patient consent
- Active infective endocarditis
- Relative mitral regurgitation due to left ventricular disease
- Other moderate to severe dysfunctional valve
- Previous cardiac surgery
- Pregnancy
- Sepsis
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (6)
Herz-Zentrum Bad Krozingen
Bad Krozingen, 79189, Germany
Kerkhoff Klinik
Bad Nauheim, 61231, Germany
Cardiology Praxis Dr. Gekeler
Loerrach, 79540, Germany
Cardiology Praxis Dr. Cron/ Dr. Hess
Basel, 4051, Switzerland
Cardiology Praxis Prof. A. Hoffmann
Basel, 4052, Switzerland
University Hospital of Basel
Basel, Switzerland
Biospecimen
Blood samples
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Christian Mueller, Prof.
University Hospital, Basel, Switzerland
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 30, 2007
First Posted
July 31, 2007
Study Start
April 1, 2006
Primary Completion
December 1, 2023
Study Completion
December 1, 2023
Last Updated
February 28, 2025
Record last verified: 2025-02
Data Sharing
- IPD Sharing
- Will not share