Psoriasis Longitudinal Assessment and Registry
PSOLAR
A Multicenter, Open Registry of Patients With Plaque Psoriasis Who Are Candidates for Systemic Therapy Including Biologics
2 other identifiers
observational
15,842
20 countries
310
Brief Summary
The purpose of this study is to further evaluate the safety of infliximab, ustekinumab, and guselkumab in patients with plaque and other forms of psoriasis. The study also includes patients receiving other therapies, such as non-biologic and other biologic agents. The registry also evaluates patient and disease characteristics, including patient-reported assessment of psoriatic arthritis (PsA); and clinical and quality of life outcomes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2007
Longer than P75 for all trials
310 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 21, 2007
CompletedFirst Submitted
Initial submission to the registry
July 27, 2007
CompletedFirst Posted
Study publicly available on registry
July 30, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2030
April 13, 2026
April 1, 2026
22.5 years
July 27, 2007
April 9, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Adverse Events and Serious Adverse Events
An AE is any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship. SAE is an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial or prolonged inpatient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly; suspected transmission of any infectious agent via medicinal product; any important medical events. All adverse events, including those of special interest, such as malignancies;TB;opportunistic infections;depression;hypersensitivity reactions; autoimmune disease; neurologic or demyelinating events; congestive heart failure; gastrointestinal events; demyelinating disease, hepatotoxicity; hematologic events; unexpected reaction to a vaccine;cerebrovascular accident; transient ischemic attack; confirmed myocardial infarction; acquired immunodeficiency syndrome will be documented.
Up to 8 years of follow up for each patient
Secondary Outcomes (6)
Evaluation of disease features: Physicians global assessment of disease activity (PGA) Score
At baseline and every 6 months through up to 8 years
Evaluation of Disease Features: Body surface area
At baseline and every 6 months through up to 8 years
Evaluation of Disease Features: Psoriasis Area and Severity Index (PASI) Score
At baseline and every 6 months through up to 8 years
Dermatology Life Quality Index (DLQI) Score
At baseline and every 6 months through up to 8 years
EuroQOL quality of life assessment
At baseline and every 6 months through up to 8 years
- +1 more secondary outcomes
Study Arms (6)
Guselkumab
Participants will receive guselkumab as prescribed by a physician according to standard of care for psoriasis.
Infliximab
Participants will receive infliximab as prescribed by a physician according to standard of care for psoriasis.
Ustekinumab
Participants will receive ustekinumab as prescribed by a physician according to standard of care for psoriasis.
Biological Therapies
Participants will receive biological therapies other than infliximab, ustekinumab, guselkumab, and IL-17 inhibitors as prescribed by a physician for psoriasis. Participants will not receive any intervention as a part of this study.
Conventional Systemic Agents
Participants will receive conventional systemic agents as prescribed by a physician for psoriasis. Participants will not receive any intervention as a part of this study.
IL-17 Inhibitor
Participants will receive an IL-17 inhibitor as prescribed by a physician according to standard of care for psoriasis.
Eligibility Criteria
Any patient with psoriasis who meets the inclusion criteria will be eligible to participate in this registry.
You may qualify if:
- Have a diagnosis of psoriasis
- Incident or prevalent users of Tremfya or an IL-17 inhibitor (eg, secukinumab, ixekizumab, brodalumab, bimekizumab) at the time of their enrollment. Incident users are defined as those participants starting treatment within 30 days before or after the enrollment visit and prevalent users are defined as those who are on treatment greater than 30 days prior to the enrollment visit
- Ability to understand and sign an informed consent form
- Are willing to participate in regular follow-up visits
You may not qualify if:
- Refuse to consent or are unwilling to respond to requests for long term information within the required time frame
- Are participating or have already planned to participate in a clinical trial with non-marketed investigational agents or are participating in a Janssen-sponsored clinical trial with marketed agents
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (320)
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Birmingham, Alabama, United States
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Florence, Alabama, United States
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Huntsville, Alabama, United States
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Phoenix, Arizona, United States
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Scottsdale, Arizona, United States
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Tucson, Arizona, United States
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Rogers, Arkansas, United States
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Bakersfield, California, United States
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Clovis, California, United States
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Fountain Valley, California, United States
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Fresno, California, United States
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Loma Linda, California, United States
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Los Angeles, California, United States
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Mountain View, California, United States
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Oxnard, California, United States
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Redding, California, United States
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Rolling Hills Estates, California, United States
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San Diego, California, United States
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San Ramon, California, United States
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Santa Monica, California, United States
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Sherman Oaks, California, United States
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Upland, California, United States
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Vallejo, California, United States
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Colorado Springs, Colorado, United States
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Englewood, Colorado, United States
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Bridgeport, Connecticut, United States
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Farmington, Connecticut, United States
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Newark, Delaware, United States
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Wilmington, Delaware, United States
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Washington D.C., District of Columbia, United States
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Aventura, Florida, United States
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Bay Pines, Florida, United States
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Boca Raton, Florida, United States
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Boynton Beach, Florida, United States
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Coral Gables, Florida, United States
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Delray Beach, Florida, United States
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Dunedin, Florida, United States
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Hollywood, Florida, United States
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Jacksonville, Florida, United States
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Melbourne, Florida, United States
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Miami, Florida, United States
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Naples, Florida, United States
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North Miami Beach, Florida, United States
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Panama City, Florida, United States
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Pembroke Pines, Florida, United States
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Seminole, Florida, United States
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Tampa, Florida, United States
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Alpharetta, Georgia, United States
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Atlanta, Georgia, United States
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Birmingham, Georgia, United States
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Carrollton, Georgia, United States
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Conyers, Georgia, United States
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Lilburn, Georgia, United States
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Macon, Georgia, United States
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Marietta, Georgia, United States
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Rome, Georgia, United States
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Twin Falls, Idaho, United States
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Champaign, Illinois, United States
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Chicago, Illinois, United States
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Lincolnshire, Illinois, United States
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Maywood, Illinois, United States
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Rolling Meadows, Illinois, United States
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Schaumburg, Illinois, United States
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Skokie, Illinois, United States
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Springfield, Illinois, United States
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West Dundee, Illinois, United States
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Winfield, Illinois, United States
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Evansville, Indiana, United States
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Indianapolis, Indiana, United States
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New Albany, Indiana, United States
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Plainfield, Indiana, United States
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West Lafayette, Indiana, United States
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Topeka, Kansas, United States
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Corbin, Kentucky, United States
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Lexington, Kentucky, United States
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New Orleans, Louisiana, United States
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Boston, Massachusetts, United States
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Quincy, Massachusetts, United States
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Ann Arbor, Michigan, United States
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Clarkston, Michigan, United States
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Clinton Township, Michigan, United States
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Farmington, Michigan, United States
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Flint, Michigan, United States
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Fort Gratiot, Michigan, United States
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Grand Blanc, Michigan, United States
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Grand Rapids, Michigan, United States
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Monroe, Michigan, United States
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Norton Shores, Michigan, United States
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Troy, Michigan, United States
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Warren, Michigan, United States
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Eagan, Minnesota, United States
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Chesterfield, Missouri, United States
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St Louis, Missouri, United States
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Helena, Montana, United States
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Henderson, Nevada, United States
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Las Vegas, Nevada, United States
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Lebanon, New Hampshire, United States
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Nashua, New Hampshire, United States
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Belleville, New Jersey, United States
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East Windsor, New Jersey, United States
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Hoboken, New Jersey, United States
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Marlton, New Jersey, United States
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Rutherford, New Jersey, United States
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Somerset, New Jersey, United States
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Verona, New Jersey, United States
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Wyckoff, New Jersey, United States
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Auburn, New York, United States
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Commack, New York, United States
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East Syracuse, New York, United States
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Elmhurst, New York, United States
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Garden City, New York, United States
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Huntington, New York, United States
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Lawrence, New York, United States
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New York, New York, United States
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Oceanside, New York, United States
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Rochester, New York, United States
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Smithtown, New York, United States
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Staten Island, New York, United States
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Stony Brook, New York, United States
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Suffern, New York, United States
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Syracuse, New York, United States
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The Bronx, New York, United States
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White Plains, New York, United States
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Williamsville, New York, United States
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Chapel Hill, North Carolina, United States
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Raleigh, North Carolina, United States
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Rocky Mount, North Carolina, United States
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Wilmington, North Carolina, United States
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Akron, Ohio, United States
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Cincinnati, Ohio, United States
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Columbus, Ohio, United States
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Dayton, Ohio, United States
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Delaware, Ohio, United States
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Gahanna, Ohio, United States
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Warren, Ohio, United States
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Oklahoma City, Oklahoma, United States
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Coos Bay, Oregon, United States
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Portland, Oregon, United States
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Exton, Pennsylvania, United States
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Fort Washington, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Pittsburgh, Pennsylvania, United States
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Plymouth Meeting, Pennsylvania, United States
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Charleston, South Carolina, United States
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Fort Mill, South Carolina, United States
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Piedmont, South Carolina, United States
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Spartanburg, South Carolina, United States
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Bartlett, Tennessee, United States
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Bristol, Tennessee, United States
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Kingsport, Tennessee, United States
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Arlington, Texas, United States
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Cedar Hill, Texas, United States
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Dallas, Texas, United States
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Houston, Texas, United States
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Longview, Texas, United States
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Salt Lake City, Utah, United States
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Arlington, Virginia, United States
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Norfolk, Virginia, United States
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Kennewick, Washington, United States
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Mount Vernon, Washington, United States
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Seattle, Washington, United States
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Tacoma, Washington, United States
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University Place, Washington, United States
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Walla Walla, Washington, United States
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Green Bay, Wisconsin, United States
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Pleasant Prairie, Wisconsin, United States
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Sheboygan, Wisconsin, United States
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Buenos Aires, Argentina
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CABA, Argentina
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Cipolletti, Argentina
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Lomas de Zamora, Argentina
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San Miguel, Argentina
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Fremantle, Australia
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Melbourne, Australia
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Miranda, Australia
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Sydney, Australia
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Woolloongabba, Australia
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Althofen, Austria
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Feldkirch, Austria
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Graz, Austria
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Klagenfurt, Austria
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Laakirchen, Austria
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Sankt Pölten, Austria
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Vienna, Austria
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Villach, Austria
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Bruges, Belgium
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Brussels, Belgium
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Edegem, Belgium
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Ghent, Belgium
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Leuven, Belgium
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Liège, Belgium
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Mons, Belgium
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Calgary, Alberta, Canada
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Edmonton, Alberta, Canada
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Nanaimo, British Columbia, Canada
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Surrey, British Columbia, Canada
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Vancouver, British Columbia, Canada
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Winnipeg, Manitoba, Canada
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Fredericton, New Brunswick, Canada
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Moncton, New Brunswick, Canada
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St. John's, Newfoundland and Labrador, Canada
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Halifax, Nova Scotia, Canada
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Kentville, Nova Scotia, Canada
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Barrie, Ontario, Canada
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Coburg, Ontario, Canada
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Greater Sudbury, Ontario, Canada
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Hamilton, Ontario, Canada
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Kingston, Ontario, Canada
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Kitchener, Ontario, Canada
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London, Ontario, Canada
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Markham, Ontario, Canada
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Mississauga, Ontario, Canada
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Newmarket, Ontario, Canada
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North Bay, Ontario, Canada
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Ottawa, Ontario, Canada
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Peterborough, Ontario, Canada
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Saint Catherines, Ontario, Canada
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Toronto, Ontario, Canada
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Windsor, Ontario, Canada
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Drummondville, Quebec, Canada
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Montreal, Quebec, Canada
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Québec, Quebec, Canada
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Santiago, Chile
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Santiago - Las Condes, Chile
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Santiago - Macul, Chile
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Bogotá, Colombia
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MedellĂn, Colombia
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Brno, Czechia
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České Budějovice, Czechia
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Jihlava, Czechia
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Náchod, Czechia
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NovĂ˝ JiÄŤĂn, Czechia
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Olomouc, Czechia
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Pardubice, Czechia
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Pilsen, Czechia
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Prague, Czechia
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Ĺ umperk, Czechia
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ĂšstĂ nad Labem, Czechia
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Athens, Greece
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Heraklion, Greece
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Ioannina, Greece
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Larissa, Greece
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Pátrai, Greece
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Piraeus-Athens, Greece
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PsychikĂł, Greece
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Thessaloniki, Greece
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Afula, Israel
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Beersheba, Israel
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Haifa, Israel
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Netivot, Israel
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Petah Tikva, Israel
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Ramat Gan, Israel
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Tel Aviv, Israel
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Hirakata, Japan
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Hokkaido, Japan
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Itabashi Ku, Japan
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Kobe, Japan
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Kurume, Japan
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Matsumoto, Japan
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ĹŚita, Japan
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Takamatsu, Japan
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Tokyo, Japan
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Tsu, Japan
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Yokosuka, Japan
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Estado de MĂ©xico, Mexico
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Mexico City, Mexico
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Monterrey, Mexico
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Zapopan, Mexico
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Alkmaar, Netherlands
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Amsterdam-Zuidoost, Netherlands
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Breda, Netherlands
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Deventer, Netherlands
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Helmond, Netherlands
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Nijmegen, Netherlands
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Braga, Portugal
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Lisbon, Portugal
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Porto, Portugal
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Vila Nova de Gaia, Portugal
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Banská Bystrica, Slovakia
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Bratislava, Slovakia
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Košice, Slovakia
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Martin, Slovakia
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Nitra, Slovakia
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Poprad, Slovakia
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Prešov, Slovakia
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Trnava, Slovakia
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Celje, Slovenia
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Izola, Slovenia
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Kranj, Slovenia
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Ljubljana, Slovenia
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Maribor, Slovenia
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Busan, South Korea
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Gyeonggi-do, South Korea
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Seongnam-si, South Korea
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Seoul, South Korea
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Sungnam, South Korea
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Alcalá de Henares, Spain
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Bilbao, Spain
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Granada, Spain
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Madrid, Spain
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Majadahonda, Spain
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Murcia, Spain
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Salamanca, Spain
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Santiago de Compostela, Spain
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Eskilstuna, Sweden
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Gothenburg, Sweden
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Kungsbacka, Sweden
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Stockholm, Sweden
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Kaohsiung City, Taiwan
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Taichung, Taiwan
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Taipei, Taiwan
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Taoyuan, Taiwan
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Dnipro, Ukraine
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Donetsk, Ukraine
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Kharkiv, Ukraine
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Khmelnitskiy, Ukraine
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Kiev, Ukraine
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Luhansk, Ukraine
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Simferopol, Ukraine
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Uzhhorod, Ukraine
Related Publications (5)
Ritchlin CT, Stahle M, Poulin Y, Bagel J, Chakravarty SD, Kafka S, Srivastava B, Langholff W, Gottlieb AB. Serious infections in patients with self-reported psoriatic arthritis from the Psoriasis Longitudinal Assessment and Registry (PSOLAR) treated with biologics. BMC Rheumatol. 2019 Nov 28;3:52. doi: 10.1186/s41927-019-0094-3. eCollection 2019.
PMID: 31799498DERIVEDKavanaugh A, Papp K, Gottlieb AB, de Jong EMGJ, Chakravarty SD, Kafka S, Langholff W, Farahi K, Srivastava B, Scher JU. Demography, baseline disease characteristics, and treatment history of psoriasis patients with self-reported psoriatic arthritis enrolled in the PSOLAR registry. BMC Rheumatol. 2018 Sep 29;2:29. doi: 10.1186/s41927-018-0034-7. eCollection 2018.
PMID: 30886979DERIVEDSingh S, Kalb RE, de Jong EMGJ, Shear NH, Lebwohl M, Langholff W, Hopkins L, Srivastava B, Armstrong AW. Effect of Age of Onset of Psoriasis on Clinical Outcomes with Systemic Treatment in the Psoriasis Longitudinal Assessment and Registry (PSOLAR). Am J Clin Dermatol. 2018 Dec;19(6):879-886. doi: 10.1007/s40257-018-0388-z.
PMID: 30267377DERIVEDStrober BE, Bissonnette R, Fiorentino D, Kimball AB, Naldi L, Shear NH, Goyal K, Fakharzadeh S, Calabro S, Langholff W, You Y, Galindo C, Lee S, Lebwohl MG. Comparative effectiveness of biologic agents for the treatment of psoriasis in a real-world setting: Results from a large, prospective, observational study (Psoriasis Longitudinal Assessment and Registry [PSOLAR]). J Am Acad Dermatol. 2016 May;74(5):851-61.e4. doi: 10.1016/j.jaad.2015.12.017. Epub 2016 Feb 4.
PMID: 26853180DERIVEDKalb RE, Fiorentino DF, Lebwohl MG, Toole J, Poulin Y, Cohen AD, Goyal K, Fakharzadeh S, Calabro S, Chevrier M, Langholff W, You Y, Leonardi CL. Risk of Serious Infection With Biologic and Systemic Treatment of Psoriasis: Results From the Psoriasis Longitudinal Assessment and Registry (PSOLAR). JAMA Dermatol. 2015 Sep;151(9):961-9. doi: 10.1001/jamadermatol.2015.0718.
PMID: 25970800DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Janssen Scientific Affairs, LLC Clinical Trial
Janssen Scientific Affairs, LLC
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 8 Years
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 27, 2007
First Posted
July 30, 2007
Study Start
June 21, 2007
Primary Completion (Estimated)
December 31, 2029
Study Completion (Estimated)
December 31, 2030
Last Updated
April 13, 2026
Record last verified: 2026-04