Liverpool Lung Project: Risk Factors and Genetic Markers in Healthy Participants and Patients With Lung Cancer
3 other identifiers
observational
8,300
1 country
5
Brief Summary
RATIONALE: Environmental exposure and genetic predisposition may affect the risk of developing cancer later in life. Learning about genetic markers and the long-term effects of environmental exposure may help the study of lung cancer in the future. PURPOSE: This research study is looking at risk factors and genetic markers in healthy participants and in patients with lung cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
5 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 1998
CompletedFirst Submitted
Initial submission to the registry
July 17, 2007
CompletedFirst Posted
Study publicly available on registry
July 19, 2007
CompletedMay 15, 2013
November 1, 2007
July 17, 2007
May 14, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (5)
Prepare a molecular genetic and epidemiological risk assessment model based on the analysis of environmental exposures and genetic predisposition, which will provide an algorithm to measure an individual's risk for developing lung cancer
Develop an archive of specimens relating to at-risk individuals and those with lung cancer
Redefine lung cancer based on molecular pathology using the fields of expression and methylation profiling, and genetic instability
Identify and assess novel markers of pre-carcinogenesis in high-risk populations
Facilitate the development of new intervention strategies (i.e., chemoprevention)
Interventions
Eligibility Criteria
You may qualify if:
- Prospective cohort:
- Age 45-79
- Living within the Liverpool electoral wards
- Case-control:
- Upper age limit of 80 years old
- Resident within Liverpool Lung Project area
You may not qualify if:
- Both cohorts:
- Unable to provide competent informed consent
- Ineligible to approach based on consultant/clinical team advice
- Infectious respiratory disease (i.e., chest infection and are on antibiotics) within the past 3 months
- Untreated pulmonary tuberculosis within the past 3 months
- PRIOR CONCURRENT THERAPY:
- Participant and/or patient must not have had any of the following treatments within the last 3 months and is not planning to undergo any of them:
- Cardiac surgery
- Thoracic surgery
- Carotid artery surgery
- Abdominal surgery
- Chemotherapy
- Deep x-ray therapy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (5)
University of Liverpool Cancer Research Centre
Liverpool, England, L3 9TA, United Kingdom
Aintree University Hospital
Liverpool, England, L9 7AL, United Kingdom
Clatterbridge Centre for Oncology
Merseyside, England, CH63 4JY, United Kingdom
Whiston Hospital
Prescot Merseyside, England, L35 5DR, United Kingdom
Cardiothoracic Centre - Liverpool
Liverpool, L14 3PE, United Kingdom
Related Publications (1)
Field JK, Smith DL, Duffy S, Cassidy A. The Liverpool Lung Project research protocol. Int J Oncol. 2005 Dec;27(6):1633-45.
PMID: 16273220BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
John K. Field, MA, BDS, PhD, FRCPath
University of Liverpool Cancer Research Centre
Study Design
- Study Type
- observational
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
July 17, 2007
First Posted
July 19, 2007
Study Start
August 1, 1998
Last Updated
May 15, 2013
Record last verified: 2007-11