NCT00498199

Brief Summary

This study consists of two parts. The first part is a survey to examine vision-specific health-related quality of life in a cohort of patients with multiple sclerosis. We test visual impairment like visual acuity, visual field, colour discrimination, contrast sensitivity, eye movement. The aim of this part is to examine the association between responses to the quality of life scale and objective measures of visual impairment. The second part is an open controlled study, in which we measure motion detection threshold in MS patients with oscillopsia due to pendular nystagmus and in a group of control subjects. The objective of this part is to determine whether patients with pendular nystagmus develop adaptation to oscillopsia using increased threshold of motion detection. We plan to test the effect of visuo-motor rehabilitation on this threshold in patients with oscillopsia due to pendular nystagmus.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for all trials

Geographic Reach
1 country

1 active site

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2007

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

July 6, 2007

Completed
3 days until next milestone

First Posted

Study publicly available on registry

July 9, 2007

Completed
Last Updated

September 30, 2010

Status Verified

July 1, 2007

First QC Date

July 6, 2007

Last Update Submit

September 29, 2010

Conditions

Multiple Sclerosis

Keywords

Multiples sclerosisoscillopsiaeye movementsmotion detectionretinal slipnystagmus

Interventions

visual testsPROCEDURE

Eligibility Criteria

Age18 Years - 90 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients with established multiple sclerosis

You may qualify if:

  • Age 18 to 90
  • Patients with established multiple sclerosis
  • Visual impairment recovering from MS
  • Understanding rules task
  • Patient can stay set a long time
  • Patient's agreement
  • Membership to the Social Security
  • No relapsing since three months

You may not qualify if:

  • Brain damage
  • Cognitive or behaviour disorder
  • Patients with peripheral vestibular, otologic or ophthalmologic pathology antecedent
  • Not stabilized disease (other one than MS)
  • Patient under guardianship

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Caroline Tilikete

Lyon, 69677, France

Location

MeSH Terms

Conditions

Multiple SclerosisNystagmus, Pathologic

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNSAutoimmune Diseases of the Nervous SystemNervous System DiseasesDemyelinating DiseasesAutoimmune DiseasesImmune System DiseasesOcular Motility DisordersCranial Nerve DiseasesEye Diseases

Study Officials

  • Caroline Tilikete, MD

    Hospices Civils de Lyon

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

July 6, 2007

First Posted

July 9, 2007

Study Start

April 1, 2007

Last Updated

September 30, 2010

Record last verified: 2007-07

Locations

FR(1)