A Study on a New Staining Method (C4d Staining) of Transplanted Kidney Biopsies

NCT00498095 | Completed

• 2 other identifiers: KW/EX/06-054HARECCTR0500061
• Study Type: observational
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

Patients who had received kidney transplantation may suffer from rejection. Recently, positive staining for C4d in kidney biopsies of malfunctioning transplant kidney is increasingly recognized as an important prognostic indicator of poorer long-term kidney outcome. Data is, however, lacking in Hong Kong.

Conditions

Kidney Transplantation; Graft Rejection

Keywords

Delayed renal graft function; Acute renal allograft dysfunction

Interventions

Renal biopsy PROCEDURE

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All renal allograft biopsies performed in Princess Margaret Hospital from 1st April 2002 to 31st March 2006 on Chinese patients who were ≥ 18 years old were retrospectively reviewed. Renal transplantations were either cadaveric or living-donor related performed in Hong Kong or Mainland China. All recipients' sera produced negative cross-match tests with donor lymphocytes before transplantation and were ABO compatible. Finally, 52 renal biopsies were included. 38 (73.1%) of them were performed for unexplained acute renal deterioration whilst the rest were done for delayed graft function.

You may qualify if:

• All renal allograft biopsies performed in Princess Margaret Hospital (PMH) during the period 1st April 2003 to 31st August 2005 for unexplained acute renal dysfunction (Creatinine rise from baseline by ≥ 20%) or delayed graft function in the immediate post-transplantation period were included in the study. Both cadaveric and living-donor transplant allografts were included.

You may not qualify if:

• patients who were \< 18 years' old at the time of renal biopsy or whose records were so incomplete that preclude meaningful analysis

Sponsors & Collaborators

• Hospital Authority, Hong Kong: lead

Study Sites (1)

Princess Margaret Hospital

Hong Kong, China

Location

Study Officials

• Sze Kit Yuen, Dr

  Department of Medicine & Geriatrics, ICU, Caritas Medical Centre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV

Study Record Dates

• First Submitted: July 6, 2007
• First Posted: July 9, 2007
• Study Start: July 1, 2006
• Study Completion: December 1, 2006
• Last Updated: June 16, 2011

Record last verified: 2011-06

Locations

CN (1)