Repetitive Behavior Disorders in People With Severe Mental Retardation
Stereotypies and Mental Retardation: Neurobiological Basis
1 other identifier
interventional
N/A
1 country
2
Brief Summary
Repetitive behavior disorders are prevalent among people with severe mental retardation. These disorders can interfere significantly with an individual's daily functions. This trial is part of a long-term project that has studied the biologic basis of and possible treatments for repetitive behavior disorders. The trial will evaluate the effectiveness of two medications, a selective serotonin reuptake inhibitor (SSRI) and an atypical antipsychotic, in treating repetitive behavior disorders in people with mental retardation.
Trial Health
Trial Health Score
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2 active sites
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 1992
CompletedFirst Submitted
Initial submission to the registry
June 22, 2007
CompletedFirst Posted
Study publicly available on registry
June 26, 2007
CompletedJune 26, 2007
May 1, 2003
June 22, 2007
June 22, 2007
Conditions
Keywords
Interventions
Eligibility Criteria
You may qualify if:
- Mental retardation
- Medically stable resident of either Western Carolina Center, Morganton, NC or Tacachale Community, Gainesville, FL
- Free of sensory deficits
- Ambulatory
- High rate of stereotyped behavior that may co-occur with self-injurious or compulsive behaviors
You may not qualify if:
- Poor general health
- Cardiac, hepatic, or renal abnormalities
- Seizure within 4 months prior to study entry (patients on seizure medication who have not had a seizure within 4 months prior to study entry may participate)
- Tardive dyskinesia
- Akathisia
- Neuroleptic use within 6 months of study entry
- History of sensitivity to ergot alkaloids
- Hypertension
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Department of Psychiatry
Gainesville, Florida, 32610-0256, United States
Western Carolina Center
Morganton, North Carolina, 28655, United States
Related Publications (4)
Bodfish JW, Crawford TW, Powell SB, Parker DE, Golden RN, Lewis MH. Compulsions in adults with mental retardation: prevalence, phenomenology, and comorbidity with stereotypy and self-injury. Am J Ment Retard. 1995 Sep;100(2):183-92.
PMID: 8527113BACKGROUNDLewis MH, Bodfish JW, Powell SB, Wiest K, Darling M, Golden RN. Plasma HVA in adults with mental retardation and stereotyped behavior: biochemical evidence for a dopamine deficiency model. Am J Ment Retard. 1996 Jan;100(4):413-8. No abstract available.
PMID: 8718995BACKGROUNDBodfish JW, Symons FJ, Parker DE, Lewis MH. Varieties of repetitive behavior in autism: comparisons to mental retardation. J Autism Dev Disord. 2000 Jun;30(3):237-43. doi: 10.1023/a:1005596502855.
PMID: 11055459BACKGROUNDBodfish JW, Parker DE, Lewis MH, Sprague RL, Newell KM. Stereotypy and motor control: differences in the postural stability dynamics of persons with stereotyped and dyskinetic movement disorders. Am J Ment Retard. 2001 Mar;106(2):123-34. doi: 10.1352/0895-8017(2001)1062.0.CO;2.
PMID: 11321603BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Mark Lewis, PhD
University of Florida
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Purpose
- TREATMENT
- Intervention Model
- FACTORIAL
- Sponsor Type
- NIH
Study Record Dates
First Submitted
June 22, 2007
First Posted
June 26, 2007
Study Start
September 1, 1992
Last Updated
June 26, 2007
Record last verified: 2003-05