Periodontal and Periapical Inflammation and Pregnancy

NCT00490165 | Completed

• 1 other identifier: 2006-0198
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This is a retrospective chart review of patient records at the University of Mississippi Medical Center. We are not actively recruiting patients for this study. Recent animal studies we conducted showed that periapical abscesses during pregnancy cause a systemic inflammatory response in the mother. Also due to the increase in TNF-alpha (an inflammatory cytokine) the mother also become insulin resistant and thus developed gestational diabetes. Periodontal inflammation has been shown in the research to lead to low-birth weight and pre-term birth. We are looking retrospectively to see if an association exists in charted data between periapical and periodontal inflammation and adverse pregnancy outcomes.

Conditions

Periodontal Disease; Periapical Disease; Pregnancy; Diabetes; Cardiovascular Disease; Dental Caries

Eligibility Criteria

• Age: 10 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We are looking at charts of patients (former patients) at the University of Mississippi School of Dentistry. Since this is a pregnancy study we are looking only at the charts of female patients. The youngest record we review is 10 and there is no upper limit to the age.

You may qualify if:

• Female
• Child bearing age or above

You may not qualify if:

• Male
• Very young children (before child-bearing age)

Sponsors & Collaborators

• Roger Johnson: lead

Study Sites (1)

University of Mississippi Medical Center

Jackson, Mississippi, 39202, United States

Location

MeSH Terms

Conditions

Periodontal Diseases; Periapical Diseases; Diabetes Mellitus; Cardiovascular Diseases; Dental Caries

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Jaw Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Tooth Demineralization; Tooth Diseases

Study Officials

• Jennifer L Bain, BS

  University of Mississippi Medical Center

  PRINCIPAL INVESTIGATOR

• Roger Johnson, PhD; DMD

  University of Mississippi Medical Center

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 20, 2007
• First Posted: June 22, 2007
• Study Start: March 1, 2007
• Primary Completion: December 1, 2011
• Study Completion: December 1, 2011
• Last Updated: April 6, 2012

Record last verified: 2012-04

Locations

US (1)