NCT00480025

Brief Summary

The purpose of this clinical trial is to demonstrate the benefit of the immunotherapeutic product GSK1572932A when given to patients with Non-Small Cell Lung Cancer, after removal of their tumor. A course of 13 injections will be administered over 27 months. The Protocol Posting has been updated in order to comply with the FDA Amendment Act, Sep 2007.

Trial Health

68
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
2,278

participants targeted

Target at P75+ for phase_3

Timeline
Completed

Started Oct 2007

Longer than P75 for phase_3

Geographic Reach
32 countries

610 active sites

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 29, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 30, 2007

Completed
4 months until next milestone

Study Start

First participant enrolled

October 4, 2007

Completed
6.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 6, 2013

Completed
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

September 23, 2014

Completed
4.4 years until next milestone

Results Posted

Study results publicly available

January 30, 2019

Completed
Last Updated

December 22, 2020

Status Verified

November 1, 2020

Enrollment Period

6.2 years

First QC Date

May 29, 2007

Results QC Date

December 5, 2016

Last Update Submit

November 27, 2020

Conditions

Keywords

ASCIImmunotherapeuticMAGRITTumor antigenNon-small-cell lung cancerAdjuvant cancer therapy

Outcome Measures

Primary Outcomes (2)

  • Person Year Rate (PYAR) as Regards Disease-free Survival (DFS) in the Overall Population

    DFS = time interval from randomization to 1st evidence of recurrence/death, if occurring before. All recurrence types were included, including local, regional \& distant metastasis \& 2nd primary lung cancer (i.e. local recurrence, defined as a tumor within same lung or at bronchial stump; regional recurrence, involving a clinically or radiologically manifest disease in mediastinum or supraclavicular nodes; \& distant recurrence \[any tumor arising in contralateral lung or outside hemithorax\]). Deaths occurring without prior documentation of recurrence were considered as event \& not censored. If no event occurred by time of analysis, time to event was censored at last assessment date of patient. New 1ry cancers outside lungs were not considered as event. PYAR= n (number of subjects reported with at least 1 event) divided by T (sum of follow-up period \[in years\] censored at 1st occurrence of event in group). Median DFS estimates were obtained non-parametrically by Kaplan-Meier method.

    From administration of first dose of GSK1572932 study product/placebo solution to data lock point (DLP) on 23 January 2014 (up to 5 years per patient)

  • Person Year Rate (PYAR) as Regards Disease-free Survival (DFS) in the No-CT Population

    DFS = time interval from randomization to 1st evidence of recurrence/death, if occurring before. All recurrence types were included, including local, regional \& distant metastasis \& 2nd primary lung cancer (i.e. local recurrence, defined as a tumor within same lung or at bronchial stump; regional recurrence, involving a clinically or radiologically manifest disease in mediastinum or supraclavicular nodes; \& distant recurrence \[any tumor arising in contralateral lung or outside hemithorax\]). Deaths occurring without prior documentation of recurrence were considered as event \& not censored. If no event occurred by time of analysis, time to event was censored at last assessment date of patient. New 1ry cancers outside lungs were not considered as event. PYAR= n (number of subjects reported with at least 1 event) divided by T (sum of follow-up period \[in years\] censored at 1st occurrence of event in group). Median DFS estimates were obtained non-parametrically by Kaplan-Meier method.

    From administration of first dose of GSK1572932 study product/placebo solution to data lock point (DLP) on 23 January 2014 (up to 5 years per patient)

Secondary Outcomes (30)

  • Person Year Rate (PYAR) as Regards Disease-free Survival (DFS) in the CT Population

    From administration of first dose of GSK1572932 study product/placebo solution to data lock point (DLP) on 23 January 2014 (up to 5 years per patient)

  • Person Year Rate (PYAR) as Regards Overall-survival (OS) in the Overall Population

    From administration of first dose of GSK1572932 study product/placebo solution to data lock point (DLP) on 23 January 2014 (up to 5 years per patient)

  • Person Year Rate (PYAR) as Regards Overall-survival (OS) in the No-CT Population

    From administration of first dose of GSK1572932 study product/placebo solution to data lock point (DLP) on 23 January 2014 (up to 5 years per patient)

  • Person Year Rate (PYAR) as Regards Overall-survival (OS) in the CT Population

    From administration of first dose of GSK1572932 study product/placebo solution to data lock point (DLP) on 23 January 2014 (up to 5 years per patient)

  • Person Year Rate (PYAR) as Regards Lung-cancer Specific Survival (LCSS) in the Overall Population

    From administration of first dose of GSK1572932 study product/placebo solution to data lock point (DLP) on 23 January 2014 (up to 5 years per patient)

  • +25 more secondary outcomes

Study Arms (2)

GSK1572932 Group

EXPERIMENTAL

Patients received up to 13 doses of GSK1572932, 5 doses every 3 weeks followed by 8 doses every 12 weeks.

Biological: GSK1572932A Antigen-Specific Cancer Immunotherapeutic

Placebo Group

PLACEBO COMPARATOR

Patients received up to 13 doses of placebo, 5 doses every 3 weeks followed by 8 doses every 12 weeks.

Biological: Placebo Control

Interventions

Intramuscular administration, 13 doses

GSK1572932 Group
Placebo ControlBIOLOGICAL

Intramuscular administration, 13 doses

Placebo Group

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Male or female patient with completely resected, pathologically proven stage IB, II or IIIA NSCLC.
  • Written informed consent for MAGE-A3 expression screening on tumor biopsy has been obtained from the patient prior to shipment of the sample for expression testing (before or just after surgical resection), and written informed consent for the complete study has been obtained prior to the performance of any other protocol-specific procedure.
  • Patient is ≥ 18 years of age at the time of signature of the first informed consent form.
  • The patient's tumor shows expression of MAGE-A3 gene
  • The surgical technique for resection of the patient's tumor is anatomical, involving at least a lobectomy or a sleeve lobectomy;
  • The mediastinal lymph node sampling is done according to study protocol guidelines;
  • The patient is free of metastasis, as confirmed by a negative baseline computer tomogram (CT scan) of the chest, upper abdomen and CT scan or MRI of the brain.
  • Other examinations should be performed as clinically indicated. Note that if randomization is taking place within 8 weeks after surgery, brain CT scans or brain MRI performed up to 4 weeks before surgery do not have to be repeated.
  • ECOG performance status of 0, 1 or 2 at the time of randomization.
  • Adequate bone-marrow reserve, adequate renal function and adequate hepatic function as assessed by standard laboratory criteria, and defined as:
  • Absolute neutrophil count ≥ 1.0 x 10E9/L Platelet count ≥ 75 x 10E9/L Serum creatinine ≤ 1.5 times the Upper Limit of Normal (ULN)
  • ≤ 3.0 times the ULN if due to platinum adjuvant chemotherapy Total bilirubin ≤ 1.5 times the ULN Alanine transaminase (ALAT) ≤ 2.5 times the ULN
  • If the patient is female, she must be of non-childbearing potential, i.e. have a current tubal ligation, hysterectomy, ovariectomy or be post menopausal, or if she is of childbearing potential, she must practice adequate contraception for 30 days prior to administration of study treatment, have a negative pregnancy test and continue such precautions during all study treatment period and for 2 months after completion of the injection series.
  • In the view of the investigator, the patient can and will comply with the requirements of the protocol.

You may not qualify if:

  • The primary tumor was removed by segmentectomy or wedge resection.
  • The patient shows any evidence of residual tumor after surgery.
  • The patient has received any anti-cancer specific treatment, including radiotherapy, immunotherapy, chemotherapy or neo-adjuvant chemotherapy, except:
  • For the treatment of previous malignancies as allowed by the protocol (i.e., non-melanoma skin cancers or carcinoma in situ of the cervix or effectively treated malignancy that has been in remission for over 5 years), Administration of adjuvant platinum-based chemotherapy for the treatment of the current NSCLC is allowed between surgery and randomization.
  • The patient has previous or concomitant malignancies at other sites, except effectively treated non-melanoma skin cancers or carcinoma in situ of the cervix or effectively treated malignancy that has been in remission for over 5 years and highly likely to have been cured.
  • History of allergic disease or reactions likely to be exacerbated by any component of the study investigational product.
  • The patient has an autoimmune disease such as, but not limited to, multiple sclerosis, lupus, and inflammatory bowel disease. Patients with vitiligo are not excluded.
  • The patient requires concomitant treatment with systemic corticosteroids, or any other immunosuppressive agents.
  • Note: The use of prednisone, or equivalent, \<0.5 mg/kg/day (absolute maximum 40 mg/day), or inhaled corticosteroids for COPD or topical steroids is permitted.
  • The patient has received a major organ allograft.
  • The patient is known to be HIV-positive.
  • The patient has an uncontrolled bleeding disorder.
  • The patient has uncontrolled congestive heart failure or hypertension, unstable heart disease (coronary artery disease or myocardial infarction) or uncontrolled arrhythmia at the time of enrolment.
  • The patient needs home oxygenation.
  • The patient has psychiatric or addictive disorders that may compromise his/her ability to give informed consent, or to comply with the trial procedures.
  • +3 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (620)

GSK Investigational Site

Birmingham, Alabama, 35294-3300, United States

Location

GSK Investigational Site

Mobile, Alabama, 36604, United States

Location

GSK Investigational Site

Mobile, Alabama, 36608, United States

Location

GSK Investigational Site

Phoenix, Arizona, 85013, United States

Location

GSK Investigational Site

Scottsdale, Arizona, 85258, United States

Location

GSK Investigational Site

Scottsdale, Arizona, 85259, United States

Location

GSK Investigational Site

Tucson, Arizona, 85724, United States

Location

GSK Investigational Site

Fayetteville, Arkansas, 72703, United States

Location

GSK Investigational Site

Fort Smith, Arkansas, 72917, United States

Location

GSK Investigational Site

Jonesboro, Arkansas, 72401, United States

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GSK Investigational Site

Bakersfield, California, 93309, United States

Location

GSK Investigational Site

Beverly Hills, California, 90211, United States

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GSK Investigational Site

Burbank, California, 91505, United States

Location

GSK Investigational Site

Duarte, California, 91010, United States

Location

GSK Investigational Site

Fresno, California, 93720, United States

Location

GSK Investigational Site

Greenbrae, California, 94904-2007, United States

Location

GSK Investigational Site

La Jolla, California, 92093-0987, United States

Location

GSK Investigational Site

La Jolla, California, 92093, United States

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GSK Investigational Site

Los Angeles, California, 90095, United States

Location

GSK Investigational Site

Montebello, California, 90640, United States

Location

GSK Investigational Site

Orange, California, 92868, United States

Location

GSK Investigational Site

Palm Springs, California, 92262, United States

Location

GSK Investigational Site

Palo Alto, California, 94304, United States

Location

GSK Investigational Site

Pleasant Hill, California, 94523, United States

Location

GSK Investigational Site

Rancho Mirage, California, 92270, United States

Location

GSK Investigational Site

Sacramento, California, 95816, United States

Location

GSK Investigational Site

Sacramento, California, 95817, United States

Location

GSK Investigational Site

San Diego, California, 92121, United States

Location

GSK Investigational Site

San Diego, California, 92123, United States

Location

GSK Investigational Site

San Francisco, California, 94107, United States

Location

GSK Investigational Site

Santa Rosa, California, 95403-1757, United States

Location

GSK Investigational Site

Stanford, California, 94305, United States

Location

GSK Investigational Site

Vallejo, California, 94589, United States

Location

GSK Investigational Site

West Hollywood, California, 90048, United States

Location

GSK Investigational Site

Aurora, Colorado, 80045, United States

Location

GSK Investigational Site

Colorado Springs, Colorado, 80907, United States

Location

GSK Investigational Site

Danbury, Connecticut, 06810, United States

Location

GSK Investigational Site

Torrington, Connecticut, 06790, United States

Location

GSK Investigational Site

Waterbury, Connecticut, 06708, United States

Location

GSK Investigational Site

Newark, Delaware, 19713, United States

Location

GSK Investigational Site

Washington D.C., District of Columbia, 20007, United States

Location

GSK Investigational Site

Boca Raton, Florida, 33486, United States

Location

GSK Investigational Site

Boynton Beach, Florida, 33435, United States

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GSK Investigational Site

Deerfield Beach, Florida, 33064, United States

Location

GSK Investigational Site

Fort Lauderdale, Florida, 33316, United States

Location

GSK Investigational Site

Hollywood, Florida, 33021, United States

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GSK Investigational Site

Jacksonville, Florida, 32209, United States

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GSK Investigational Site

Ocala, Florida, 34474, United States

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GSK Investigational Site

Orlando, Florida, 32804, United States

Location

GSK Investigational Site

Orlando, Florida, 32806, United States

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GSK Investigational Site

Stuart, Florida, 34994, United States

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GSK Investigational Site

Tampa, Florida, 33606, United States

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GSK Investigational Site

West Palm Beach, Florida, 33401, United States

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GSK Investigational Site

Alpharetta, Georgia, 30005, United States

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GSK Investigational Site

Athens, Georgia, 30607, United States

Location

GSK Investigational Site

Atlanta, Georgia, 30318, United States

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GSK Investigational Site

Atlanta, Georgia, 30322, United States

Location

GSK Investigational Site

Atlanta, Georgia, 30342, United States

Location

GSK Investigational Site

Augusta, Georgia, 30901, United States

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GSK Investigational Site

Macon, Georgia, 31201, United States

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GSK Investigational Site

Marietta, Georgia, 30060, United States

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GSK Investigational Site

Savannah, Georgia, 31405, United States

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GSK Investigational Site

Honolulu, Hawaii, 96813, United States

Location

GSK Investigational Site

Coeur d'Alene, Idaho, 83814, United States

Location

GSK Investigational Site

Chicago, Illinois, 60611, United States

Location

GSK Investigational Site

Chicago, Illinois, 60612, United States

Location

GSK Investigational Site

Chicago, Illinois, 60637, United States

Location

GSK Investigational Site

Decatur, Illinois, 62526, United States

Location

GSK Investigational Site

Evanston, Illinois, 60201, United States

Location

GSK Investigational Site

Harvey, Illinois, 60426, United States

Location

GSK Investigational Site

Park Ridge, Illinois, 60068, United States

Location

GSK Investigational Site

Peoria, Illinois, 61615-7822, United States

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GSK Investigational Site

Springfield, Illinois, 62794-9638, United States

Location

GSK Investigational Site

Evansville, Indiana, 47713, United States

Location

GSK Investigational Site

Indianapolis, Indiana, 46260, United States

Location

GSK Investigational Site

Indianapolis, Indiana, United States

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GSK Investigational Site

Munster, Indiana, 46321, United States

Location

GSK Investigational Site

New Albany, Indiana, 47150, United States

Location

GSK Investigational Site

Waterloo, Iowa, 50701, United States

Location

GSK Investigational Site

Ashland, Kentucky, 41101, United States

Location

GSK Investigational Site

Hazard, Kentucky, 41701, United States

Location

GSK Investigational Site

Lexington, Kentucky, 40503, United States

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GSK Investigational Site

Louisville, Kentucky, 40245, United States

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GSK Investigational Site

Owensboro, Kentucky, 42303, United States

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GSK Investigational Site

Alexandria, Louisiana, 71301, United States

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GSK Investigational Site

Metairie, Louisiana, 70006, United States

Location

GSK Investigational Site

Shreveport, Louisiana, 71101, United States

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GSK Investigational Site

Annapolis, Maryland, 21401, United States

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GSK Investigational Site

Baltimore, Maryland, 21201, United States

Location

GSK Investigational Site

Baltimore, Maryland, 21204, United States

Location

GSK Investigational Site

Baltimore, Maryland, 21215, United States

Location

GSK Investigational Site

Baltimore, Maryland, 21237, United States

Location

GSK Investigational Site

Bethesda, Maryland, 20892-1201, United States

Location

GSK Investigational Site

Silver Spring, Maryland, 20902, United States

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GSK Investigational Site

Towson, Maryland, 21204, United States

Location

GSK Investigational Site

Boston, Massachusetts, 02111, United States

Location

GSK Investigational Site

Boston, Massachusetts, 02114, United States

Location

GSK Investigational Site

Boston, Massachusetts, 02118, United States

Location

GSK Investigational Site

Worcester, Massachusetts, 01605, United States

Location

GSK Investigational Site

Worcester, Massachusetts, 01608, United States

Location

GSK Investigational Site

Ann Arbor, Michigan, 48109, United States

Location

GSK Investigational Site

Bay City, Michigan, 48706, United States

Location

GSK Investigational Site

Detroit, Michigan, 48201, United States

Location

GSK Investigational Site

Detroit, Michigan, 48202, United States

Location

GSK Investigational Site

Flint, Michigan, 48503, United States

Location

GSK Investigational Site

Grand Rapids, Michigan, 49503, United States

Location

GSK Investigational Site

Lansing, Michigan, 48910, United States

Location

GSK Investigational Site

Lapeer, Michigan, 48446, United States

Location

GSK Investigational Site

Southfield, Michigan, 48075, United States

Location

GSK Investigational Site

Minneapolis, Minnesota, 55407-3799, United States

Location

GSK Investigational Site

Minneapolis, Minnesota, 55455, United States

Location

GSK Investigational Site

Rochester, Minnesota, 55905, United States

Location

GSK Investigational Site

Saint Louis Park, Minnesota, 55416, United States

Location

GSK Investigational Site

Saint Louis Park, Minnesota, 55426, United States

Location

GSK Investigational Site

Kansas City, Missouri, 64111, United States

Location

GSK Investigational Site

Kansas City, Missouri, 64132, United States

Location

GSK Investigational Site

Springfield, Missouri, 65804, United States

Location

GSK Investigational Site

St Louis, Missouri, 63110, United States

Location

GSK Investigational Site

Billings, Montana, 59102, United States

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GSK Investigational Site

Grand Island, Nebraska, 68803, United States

Location

GSK Investigational Site

Omaha, Nebraska, 68114, United States

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GSK Investigational Site

Henderson, Nevada, 89052, United States

Location

GSK Investigational Site

Lebanon, New Hampshire, 03756, United States

Location

GSK Investigational Site

Long Branch, New Jersey, 07740, United States

Location

GSK Investigational Site

Paramus, New Jersey, 07652, United States

Location

GSK Investigational Site

Armonk, New York, 10504, United States

Location

GSK Investigational Site

Buffalo, New York, 14263, United States

Location

GSK Investigational Site

East Syracuse, New York, 13057, United States

Location

GSK Investigational Site

Flushing, New York, 11355, United States

Location

GSK Investigational Site

Mineola, New York, 11501, United States

Location

GSK Investigational Site

New York, New York, 10003, United States

Location

GSK Investigational Site

New York, New York, 10011, United States

Location

GSK Investigational Site

New York, New York, 10016, United States

Location

GSK Investigational Site

New York, New York, 10019, United States

Location

GSK Investigational Site

New York, New York, 10032, United States

Location

GSK Investigational Site

New York, New York, 10065, United States

Location

GSK Investigational Site

Syracuse, New York, 13210, United States

Location

GSK Investigational Site

Chapel Hill, North Carolina, 27599-7065, United States

Location

GSK Investigational Site

Charlotte, North Carolina, 28203, United States

Location

GSK Investigational Site

Charlotte, North Carolina, 28204, United States

Location

GSK Investigational Site

Durham, North Carolina, 27705, United States

Location

GSK Investigational Site

Durham, North Carolina, 27710, United States

Location

GSK Investigational Site

Greenville, North Carolina, 27834, United States

Location

GSK Investigational Site

Akron, Ohio, 44304, United States

Location

GSK Investigational Site

Canton, Ohio, 44710, United States

Location

GSK Investigational Site

Cincinnati, Ohio, 45242, United States

Location

GSK Investigational Site

Cincinnati, Ohio, 45267, United States

Location

GSK Investigational Site

Columbus, Ohio, 43210, United States

Location

GSK Investigational Site

Dayton, Ohio, 45429, United States

Location

GSK Investigational Site

Tulsa, Oklahoma, 74136, United States

Location

GSK Investigational Site

Bend, Oregon, 97701, United States

Location

GSK Investigational Site

Portland, Oregon, 97213, United States

Location

GSK Investigational Site

Bethlehem, Pennsylvania, 18015, United States

Location

GSK Investigational Site

Danville, Pennsylvania, 17822, United States

Location

GSK Investigational Site

Lancaster, Pennsylvania, 17605, United States

Location

GSK Investigational Site

Langhorne, Pennsylvania, 19047, United States

Location

GSK Investigational Site

Philadelphia, Pennsylvania, 19104, United States

Location

GSK Investigational Site

Philadelphia, Pennsylvania, 19111, United States

Location

GSK Investigational Site

Philadelphia, Pennsylvania, 19140, United States

Location

GSK Investigational Site

Pittsburgh, Pennsylvania, 15212, United States

Location

GSK Investigational Site

Pittsburgh, Pennsylvania, 15232, United States

Location

GSK Investigational Site

Sayre, Pennsylvania, 18840, United States

Location

GSK Investigational Site

Wilkes-Barre, Pennsylvania, 18702, United States

Location

GSK Investigational Site

Willow Grove, Pennsylvania, 19090, United States

Location

GSK Investigational Site

Providence, Rhode Island, 02903, United States

Location

GSK Investigational Site

Providence, Rhode Island, 02906, United States

Location

GSK Investigational Site

Charleston, South Carolina, 29414, United States

Location

GSK Investigational Site

Charleston, South Carolina, 29425, United States

Location

GSK Investigational Site

Columbia, South Carolina, 29209, United States

Location

GSK Investigational Site

Greenville, South Carolina, 29615, United States

Location

GSK Investigational Site

Spartanburg, South Carolina, 29303, United States

Location

GSK Investigational Site

Sumter, South Carolina, 29150, United States

Location

GSK Investigational Site

Chattanooga, Tennessee, 37421, United States

Location

GSK Investigational Site

Cookeville, Tennessee, 38501, United States

Location

GSK Investigational Site

Knoxville, Tennessee, 37905, United States

Location

GSK Investigational Site

Knoxville, Tennessee, 37920, United States

Location

GSK Investigational Site

Memphis, Tennessee, 38104, United States

Location

GSK Investigational Site

Memphis, Tennessee, 38120, United States

Location

GSK Investigational Site

Nashville, Tennessee, 37203, United States

Location

GSK Investigational Site

Amarillo, Texas, 79106, United States

Location

GSK Investigational Site

Dallas, Texas, 75230, United States

Location

GSK Investigational Site

Dallas, Texas, 75231, United States

Location

GSK Investigational Site

Dallas, Texas, 75246, United States

Location

GSK Investigational Site

Grapevine, Texas, 76051, United States

Location

GSK Investigational Site

Houston, Texas, 77030, United States

Location

GSK Investigational Site

Houston, Texas, 77090, United States

Location

GSK Investigational Site

Round Rock, Texas, 78665, United States

Location

GSK Investigational Site

Tyler, Texas, 75708-3154, United States

Location

GSK Investigational Site

Ogden, Utah, 84403, United States

Location

GSK Investigational Site

Salt Lake City, Utah, 84106, United States

Location

GSK Investigational Site

Fairfax, Virginia, 22031, United States

Location

GSK Investigational Site

Roanoke, Virginia, 24014, United States

Location

GSK Investigational Site

Everett, Washington, 98201, United States

Location

GSK Investigational Site

Seattle, Washington, 98104, United States

Location

GSK Investigational Site

Seattle, Washington, 98108, United States

Location

GSK Investigational Site

Seattle, Washington, 98109, United States

Location

GSK Investigational Site

Spokane, Washington, 99208, United States

Location

GSK Investigational Site

Tacoma, Washington, 98405, United States

Location

GSK Investigational Site

Vancouver, Washington, 98664, United States

Location

GSK Investigational Site

Madison, Wisconsin, 53792, United States

Location

GSK Investigational Site

Milwaukee, Wisconsin, 53226, United States

Location

GSK Investigational Site

C.a.b.a., Buenos Aires, C1425EHD, Argentina

Location

GSK Investigational Site

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1430CLD, Argentina

Location

GSK Investigational Site

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1125ABD, Argentina

Location

GSK Investigational Site

Córdoba, Córdoba Province, X5000JFK, Argentina

Location

GSK Investigational Site

Cipolletti, Río Negro Province, R8324EMB, Argentina

Location

GSK Investigational Site

Rosario, Santa Fe Province, S2000KZE, Argentina

Location

GSK Investigational Site

Quilmes, 1878, Argentina

Location

GSK Investigational Site

San Miguel de Tucumán, 4000, Argentina

Location

GSK Investigational Site

Santa Fe, 3000, Argentina

Location

GSK Investigational Site

Garran, Australian Capital Territory, 2606, Australia

Location

GSK Investigational Site

Camperdown, New South Wales, 2050, Australia

Location

GSK Investigational Site

Tweed Heads, New South Wales, 2485, Australia

Location

GSK Investigational Site

Waratah, New South Wales, 2298, Australia

Location

GSK Investigational Site

Westmead, New South Wales, 2145, Australia

Location

GSK Investigational Site

Chermside, Queensland, 4032, Australia

Location

GSK Investigational Site

South Brisbane, Queensland, 4101, Australia

Location

GSK Investigational Site

Woolloongabba, Queensland, 4102, Australia

Location

GSK Investigational Site

Adelaide, South Australia, 5000, Australia

Location

GSK Investigational Site

Hobart, Tasmania, 7000, Australia

Location

GSK Investigational Site

Box Hill, Victoria, 3128, Australia

Location

GSK Investigational Site

Fitzroy, Victoria, 3065, Australia

Location

GSK Investigational Site

Heidelberg, Victoria, 3084, Australia

Location

GSK Investigational Site

Richmond, Victoria, 3121, Australia

Location

GSK Investigational Site

Nedlands, Western Australia, 6009, Australia

Location

GSK Investigational Site

Perth, Western Australia, 6001, Australia

Location

GSK Investigational Site

Graz, A-8036, Austria

Location

GSK Investigational Site

Innsbruck, 6020, Austria

Location

GSK Investigational Site

Linz, A-4010, Austria

Location

GSK Investigational Site

Linz, A-4020, Austria

Location

GSK Investigational Site

Salzburg, A-5020, Austria

Location

GSK Investigational Site

Vienna, 1130, Austria

Location

GSK Investigational Site

Vienna, A-1090, Austria

Location

GSK Investigational Site

Wels, A-4600, Austria

Location

GSK Investigational Site

Antwerp, 2020, Belgium

Location

GSK Investigational Site

Brussels, 1070, Belgium

Location

GSK Investigational Site

Brussels, 1200, Belgium

Location

GSK Investigational Site

Charleroi, 6000, Belgium

Location

GSK Investigational Site

Duffel, 2570, Belgium

Location

GSK Investigational Site

Edegem, 2650, Belgium

Location

GSK Investigational Site

Genk, 3600, Belgium

Location

GSK Investigational Site

Hasselt, 3500, Belgium

Location

GSK Investigational Site

Jette, 1090, Belgium

Location

GSK Investigational Site

Leuven, 3000, Belgium

Location

GSK Investigational Site

Liège, 4000, Belgium

Location

GSK Investigational Site

Namur, 5000, Belgium

Location

GSK Investigational Site

Belo Horizonte, Minas Gerais, 30730-540, Brazil

Location

GSK Investigational Site

Porto Alegre, Rio Grande do Sul, 90610 000, Brazil

Location

GSK Investigational Site

Barretos, São Paulo, 14784-400, Brazil

Location

GSK Investigational Site

Santo André, São Paulo, 09060-650, Brazil

Location

GSK Investigational Site

Rio de Janeiro, 20230-130, Brazil

Location

GSK Investigational Site

São Paulo, 01224-010, Brazil

Location

GSK Investigational Site

São Paulo, 01308-050, Brazil

Location

GSK Investigational Site

São Paulo, 01509-900, Brazil

Location

GSK Investigational Site

Calgary, Alberta, T2N 4N2, Canada

Location

GSK Investigational Site

Edmonton, Alberta, T6G 1Z2, Canada

Location

GSK Investigational Site

Surrey, British Columbia, V3V 1N1, Canada

Location

GSK Investigational Site

Halifax, Nova Scotia, B3J 2Y9, Canada

Location

GSK Investigational Site

Hamilton, Ontario, L8V 5C2, Canada

Location

GSK Investigational Site

London, Ontario, N6A 5W9, Canada

Location

GSK Investigational Site

Newmarket, Ontario, L3Y 2P9, Canada

Location

GSK Investigational Site

Saint Catherines, Ontario, L2S 0A9, Canada

Location

GSK Investigational Site

Scarborough Village, Ontario, M1P 2V5, Canada

Location

GSK Investigational Site

Toronto, Ontario, M4C 3E7, Canada

Location

GSK Investigational Site

Toronto, Ontario, M5G 1X5, Canada

Location

GSK Investigational Site

Toronto, Ontario, M6R 1B5, Canada

Location

GSK Investigational Site

Greenfield Park, Quebec, J4V 2H1, Canada

Location

GSK Investigational Site

Montreal, Quebec, H1T 2M4, Canada

Location

GSK Investigational Site

Montreal, Quebec, H2L 4M1, Canada

Location

GSK Investigational Site

Montreal, Quebec, H3T1E2, Canada

Location

GSK Investigational Site

Montreal, Quebec, H4J 1C5, Canada

Location

GSK Investigational Site

Québec, G1V 4G5, Canada

Location

GSK Investigational Site

Guangzhou, Guangdong, 510060, China

Location

GSK Investigational Site

Guangzhou, Guangdong, 510120, China

Location

GSK Investigational Site

Nanning, Guangxi, 530021, China

Location

GSK Investigational Site

Wuhan, Hubei, 430030, China

Location

GSK Investigational Site

Nanjing, Jiangsu, 210002, China

Location

GSK Investigational Site

Changchun, Jilin, 130012, China

Location

GSK Investigational Site

Chengdu, Sichuan, 610041, China

Location

GSK Investigational Site

Hangzhou, Zhejiang, 310003, China

Location

GSK Investigational Site

Hangzhou, Zhejiang, 310022, China

Location

GSK Investigational Site

Beijing, China

Location

GSK Investigational Site

Changsha, China

Location

GSK Investigational Site

Guangzhou, China

Location

GSK Investigational Site

Harbin, China

Location

GSK Investigational Site

Shanghai, 200030, China

Location

GSK Investigational Site

Shanghai, 200032, China

Location

GSK Investigational Site

Shanghai, 200433, China

Location

GSK Investigational Site

Tianjin, 300052, China

Location

GSK Investigational Site

Wuhan, China

Location

GSK Investigational Site

Brno, 625 00, Czechia

Location

GSK Investigational Site

Ostrava, 708 52, Czechia

Location

GSK Investigational Site

Pilsen, 305 99, Czechia

Location

GSK Investigational Site

Prague, 150 06, Czechia

Location

GSK Investigational Site

Prague, 180 01, Czechia

Location

GSK Investigational Site

Ústí nad Labem, 401 12, Czechia

Location

GSK Investigational Site

Tallinn, 13419, Estonia

Location

GSK Investigational Site

Tartu, 51014, Estonia

Location

GSK Investigational Site

Helsinki, 00029, Finland

Location

GSK Investigational Site

Oulu, 90220, Finland

Location

GSK Investigational Site

Tampere, 33520, Finland

Location

GSK Investigational Site

Turku, 20520, Finland

Location

GSK Investigational Site

Angers, 49933, France

Location

GSK Investigational Site

Bayonne, 64100, France

Location

GSK Investigational Site

Beauvais, 60021, France

Location

GSK Investigational Site

Béthune, 62408, France

Location

GSK Investigational Site

Bordeaux, 33000, France

Location

GSK Investigational Site

Brest, 29609, France

Location

GSK Investigational Site

Bron, 69677, France

Location

GSK Investigational Site

Caen, 14033, France

Location

GSK Investigational Site

Elbeuf, 76503, France

Location

GSK Investigational Site

Lille, 59000, France

Location

GSK Investigational Site

Lille, 59037, France

Location

GSK Investigational Site

Limoges, 87042, France

Location

GSK Investigational Site

Lorient, 56322, France

Location

GSK Investigational Site

Lyon, 69003, France

Location

GSK Investigational Site

Lyon, 69365, France

Location

GSK Investigational Site

Lyon, 69373, France

Location

GSK Investigational Site

Marseille, 13915, France

Location

GSK Investigational Site

Meaux, 77104, France

Location

GSK Investigational Site

Metz, 57038, France

Location

GSK Investigational Site

Montpellier, 34295, France

Location

GSK Investigational Site

Mulhouse, 68070, France

Location

GSK Investigational Site

Nantes, 44202, France

Location

GSK Investigational Site

Nice, 06002, France

Location

GSK Investigational Site

Nîmes, 30029, France

Location

GSK Investigational Site

Paris, 75014, France

Location

GSK Investigational Site

Paris, 75018, France

Location

GSK Investigational Site

Paris, 75020, France

Location

GSK Investigational Site

Paris, 75248, France

Location

GSK Investigational Site

Paris, 75970, France

Location

GSK Investigational Site

Perpignan, 66000, France

Location

GSK Investigational Site

Périgueux, 24019, France

Location

GSK Investigational Site

Reims, 51100, France

Location

GSK Investigational Site

Rennes, 35033, France

Location

GSK Investigational Site

Rouen, 76000, France

Location

GSK Investigational Site

Saint-Grégoire, 35768, France

Location

GSK Investigational Site

Saint-Herblain, 44805, France

Location

GSK Investigational Site

Saint-Priest-en-Jarez, 42271, France

Location

GSK Investigational Site

Saint-Quentin, 02321, France

Location

GSK Investigational Site

Toulon, 83041, France

Location

GSK Investigational Site

Toulouse, 31059, France

Location

GSK Investigational Site

Vannes, 56017, France

Location

GSK Investigational Site

Villefranche-sur-Saône, 69655, France

Location

GSK Investigational Site

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany

Location

GSK Investigational Site

Heidelberg, Baden-Wurttemberg, 69126, Germany

Location

GSK Investigational Site

Ulm, Baden-Wurttemberg, 89081, Germany

Location

GSK Investigational Site

Villingen-Schwenningen, Baden-Wurttemberg, 78050, Germany

Location

GSK Investigational Site

Wangen, Baden-Wurttemberg, 88239, Germany

Location

GSK Investigational Site

Augsburg, Bavaria, 86156, Germany

Location

GSK Investigational Site

Bayreuth, Bavaria, 95445, Germany

Location

GSK Investigational Site

Ebensfeld, Bavaria, 96250, Germany

Location

GSK Investigational Site

Gauting, Bavaria, 82131, Germany

Location

GSK Investigational Site

Munich, Bavaria, 81925, Germany

Location

GSK Investigational Site

Regensburg, Bavaria, 93049, Germany

Location

GSK Investigational Site

Regensburg, Bavaria, 93053, Germany

Location

GSK Investigational Site

Rosenheim, Bavaria, 83022, Germany

Location

GSK Investigational Site

Würzburg, Bavaria, 97070, Germany

Location

GSK Investigational Site

Frankfurt (Oder), Brandenburg, 15236, Germany

Location

GSK Investigational Site

Darmstadt, Hesse, 64283, Germany

Location

GSK Investigational Site

Frankfurt am Main, Hesse, 60487, Germany

Location

GSK Investigational Site

Frankfurt am Main, Hesse, 60488, Germany

Location

GSK Investigational Site

Frankfurt am Main, Hesse, 60590, Germany

Location

GSK Investigational Site

Fulda, Hesse, 36043, Germany

Location

GSK Investigational Site

Immenhausen, Hesse, 34376, Germany

Location

GSK Investigational Site

Offenbach, Hesse, 63069, Germany

Location

GSK Investigational Site

Braunschweig, Lower Saxony, 38114, Germany

Location

GSK Investigational Site

Hanover, Lower Saxony, 30625, Germany

Location

GSK Investigational Site

Oldenburg, Lower Saxony, 26121, Germany

Location

GSK Investigational Site

Ostercappeln, Lower Saxony, 49179, Germany

Location

GSK Investigational Site

Greifswald, Mecklenburg-Vorpommern, 17487, Germany

Location

GSK Investigational Site

Rostock, Mecklenburg-Vorpommern, 18057, Germany

Location

GSK Investigational Site

Bielefeld, North Rhine-Westphalia, 33604, Germany

Location

GSK Investigational Site

Bielefeld, North Rhine-Westphalia, 33611, Germany

Location

GSK Investigational Site

Bochum, North Rhine-Westphalia, 44791, Germany

Location

GSK Investigational Site

Bonn, North Rhine-Westphalia, 53113, Germany

Location

GSK Investigational Site

Cologne, North Rhine-Westphalia, 50931, Germany

Location

GSK Investigational Site

Cologne, North Rhine-Westphalia, 51109, Germany

Location

GSK Investigational Site

Essen, North Rhine-Westphalia, 45122, Germany

Location

GSK Investigational Site

Essen, North Rhine-Westphalia, 45136, Germany

Location

GSK Investigational Site

Hemer, North Rhine-Westphalia, 58675, Germany

Location

GSK Investigational Site

Herne, North Rhine-Westphalia, 44623, Germany

Location

GSK Investigational Site

Lüdenscheid, North Rhine-Westphalia, 58515, Germany

Location

GSK Investigational Site

Moers, North Rhine-Westphalia, 47441, Germany

Location

GSK Investigational Site

Mülheim, North Rhine-Westphalia, 45473, Germany

Location

GSK Investigational Site

Münster, North Rhine-Westphalia, 48149, Germany

Location

GSK Investigational Site

Münster, North Rhine-Westphalia, 48153, Germany

Location

GSK Investigational Site

Neuss, North Rhine-Westphalia, 41464, Germany

Location

GSK Investigational Site

Oberhausen, North Rhine-Westphalia, 46145, Germany

Location

GSK Investigational Site

Porta Westfalica, North Rhine-Westphalia, 32457, Germany

Location

GSK Investigational Site

Troisdorf, North Rhine-Westphalia, 53840, Germany

Location

GSK Investigational Site

Velbert, North Rhine-Westphalia, 42551, Germany

Location

GSK Investigational Site

Waldbröl, North Rhine-Westphalia, 51545, Germany

Location

GSK Investigational Site

Koblenz, Rhineland-Palatinate, 56068, Germany

Location

GSK Investigational Site

Mainz, Rhineland-Palatinate, 55131, Germany

Location

GSK Investigational Site

Trier, Rhineland-Palatinate, 54290, Germany

Location

GSK Investigational Site

Homburg, Saarland, 66421, Germany

Location

GSK Investigational Site

Dresden, Saxony, 01307, Germany

Location

GSK Investigational Site

Leipzig, Saxony, 04103, Germany

Location

GSK Investigational Site

Leipzig, Saxony, 04129, Germany

Location

GSK Investigational Site

Zwickau, Saxony, 08058, Germany

Location

GSK Investigational Site

Halle, Saxony-Anhalt, 06114, Germany

Location

GSK Investigational Site

Halle, Saxony-Anhalt, 06120, Germany

Location

GSK Investigational Site

Weißenfels, Saxony-Anhalt, 06667, Germany

Location

GSK Investigational Site

Großhansdorf, Schleswig-Holstein, 22927, Germany

Location

GSK Investigational Site

Kiel, Schleswig-Holstein, 24105, Germany

Location

GSK Investigational Site

Lübeck, Schleswig-Holstein, 23538, Germany

Location

GSK Investigational Site

Bad Berka, Thuringia, 99437, Germany

Location

GSK Investigational Site

Berlin, 10117, Germany

Location

GSK Investigational Site

Berlin, 12200, Germany

Location

GSK Investigational Site

Berlin, 12351, Germany

Location

GSK Investigational Site

Berlin, 13125, Germany

Location

GSK Investigational Site

Berlin, 13353, Germany

Location

GSK Investigational Site

Bremen, 28325, Germany

Location

GSK Investigational Site

Hamburg, 20246, Germany

Location

GSK Investigational Site

Hamburg, 21075, Germany

Location

GSK Investigational Site

Athens, 10676, Greece

Location

GSK Investigational Site

Athens, 115 27, Greece

Location

GSK Investigational Site

Athens, 11526, Greece

Location

GSK Investigational Site

Athens, 11527, Greece

Location

GSK Investigational Site

Athens, 145 64, Greece

Location

GSK Investigational Site

Chania, 73100, Greece

Location

GSK Investigational Site

Heraklion, 71110, Greece

Location

GSK Investigational Site

Larissa, 411 10, Greece

Location

GSK Investigational Site

Marousi, 15125, Greece

Location

GSK Investigational Site

Neo Faliro, 18547, Greece

Location

GSK Investigational Site

Pátrai, 26500, Greece

Location

GSK Investigational Site

Piraeus, 18537, Greece

Location

GSK Investigational Site

Pylaia, 57001, Greece

Location

GSK Investigational Site

Thessaloniki, 540 07, Greece

Location

GSK Investigational Site

Thessaloniki, 57010, Greece

Location

GSK Investigational Site

Kowloon, Hong Kong

Location

GSK Investigational Site

Shatin, Hong Kong

Location

GSK Investigational Site

Budapest, 1529, Hungary

Location

GSK Investigational Site

Budapest, Hungary

Location

GSK Investigational Site

Deszk, 6772, Hungary

Location

GSK Investigational Site

Győr, 9024, Hungary

Location

GSK Investigational Site

Gyula, 5703, Hungary

Location

GSK Investigational Site

Mátraháza, 3233, Hungary

Location

GSK Investigational Site

Miskolc, 3529, Hungary

Location

GSK Investigational Site

Nyíregyháza, 4400, Hungary

Location

GSK Investigational Site

Pécs, 7623, Hungary

Location

GSK Investigational Site

Pózva, 8900, Hungary

Location

GSK Investigational Site

Székesfehérvár, 8000, Hungary

Location

GSK Investigational Site

Szombathely, 9700, Hungary

Location

GSK Investigational Site

Ahmedabad, 380 009, India

Location

GSK Investigational Site

Ahmedabad, 380016, India

Location

GSK Investigational Site

Bangalore, 560029, India

Location

GSK Investigational Site

Hyderabad, 500082, India

Location

GSK Investigational Site

Mumbai, 400012, India

Location

GSK Investigational Site

Mumbai, 400016, India

Location

GSK Investigational Site

Mumbai, 400020, India

Location

GSK Investigational Site

Dublin, 4, Ireland

Location

GSK Investigational Site

Dublin, 8, Ireland

Location

GSK Investigational Site

Dublin, 9, Ireland

Location

GSK Investigational Site

Galway, Co Galway, Ireland

Location

GSK Investigational Site

Beersheba, 84101, Israel

Location

GSK Investigational Site

Haifa, 31096, Israel

Location

GSK Investigational Site

Jerusalem, 91120, Israel

Location

GSK Investigational Site

Kfar Saba, 44281, Israel

Location

GSK Investigational Site

Ramat Gan, 52621, Israel

Location

GSK Investigational Site

Zrifin, 70300, Israel

Location

GSK Investigational Site

Bari, Apulia, 70124, Italy

Location

GSK Investigational Site

Napoli, Campania, 80131, Italy

Location

GSK Investigational Site

Bologna, Emilia-Romagna, 40139, Italy

Location

GSK Investigational Site

Meldola (FC), Emilia-Romagna, 47014, Italy

Location

GSK Investigational Site

Modena, Emilia-Romagna, 41100, Italy

Location

GSK Investigational Site

Parma, Emilia-Romagna, 43100, Italy

Location

GSK Investigational Site

Ravenna, Emilia-Romagna, 48100, Italy

Location

GSK Investigational Site

Rimini, Emilia-Romagna, 47900, Italy

Location

GSK Investigational Site

Udine, Friuli Venezia Giulia, 33100, Italy

Location

GSK Investigational Site

Rome, Lazio, 00133, Italy

Location

GSK Investigational Site

Rome, Lazio, 00152, Italy

Location

GSK Investigational Site

Rome, Lazio, 00189, Italy

Location

GSK Investigational Site

Genoa, Liguria, 16132, Italy

Location

GSK Investigational Site

Genoa, Liguria, 16149, Italy

Location

GSK Investigational Site

Lecco, Lombardy, 23900, Italy

Location

GSK Investigational Site

Milan, Lombardy, 20141, Italy

Location

GSK Investigational Site

Milan, Lombardy, 20162, Italy

Location

GSK Investigational Site

Monza, Lombardy, 20052, Italy

Location

GSK Investigational Site

Rozzano (MI), Lombardy, 20089, Italy

Location

GSK Investigational Site

Novara, Piedmont, 28100, Italy

Location

GSK Investigational Site

Orbassano (TO), Piedmont, 10043, Italy

Location

GSK Investigational Site

Turin, Piedmont, 10126, Italy

Location

GSK Investigational Site

Monserrato, Sardinia, 09042, Italy

Location

GSK Investigational Site

Palermo, Sicily, 90146, Italy

Location

GSK Investigational Site

Pisa, Tuscany, 56124, Italy

Location

GSK Investigational Site

Siena, Tuscany, 53100, Italy

Location

GSK Investigational Site

Perugia, Umbria, 06132, Italy

Location

GSK Investigational Site

Legnago, Veneto, 37045, Italy

Location

GSK Investigational Site

Padua, Veneto, 35128, Italy

Location

GSK Investigational Site

Aichi, 464-8681, Japan

Location

GSK Investigational Site

Chiba, 277-8577, Japan

Location

GSK Investigational Site

Ehime, 791-0280, Japan

Location

GSK Investigational Site

Fukuoka, 807-8555, Japan

Location

GSK Investigational Site

Fukuoka, 811-1395, Japan

Location

GSK Investigational Site

Hiroshima, 730-8518, Japan

Location

GSK Investigational Site

Hyōgo, 673-8558, Japan

Location

GSK Investigational Site

Kanagawa, 241-8515, Japan

Location

GSK Investigational Site

Niigata, 951-8566, Japan

Location

GSK Investigational Site

Osaka, 534-0021, Japan

Location

GSK Investigational Site

Osaka, 537-8511, Japan

Location

GSK Investigational Site

Shizuoka, 411-8777, Japan

Location

GSK Investigational Site

Tokyo, 104-0045, Japan

Location

GSK Investigational Site

Tokyo, 113-8431, Japan

Location

GSK Investigational Site

Tokyo, 160-0023, Japan

Location

GSK Investigational Site

Amsterdam, 1105 AZ, Netherlands

Location

GSK Investigational Site

Harderwijk, 3844 DG, Netherlands

Location

GSK Investigational Site

Heerlen, 6419 PC, Netherlands

Location

GSK Investigational Site

Leeuwarden, 8934 AD, Netherlands

Location

GSK Investigational Site

Nieuwegein, 3435 CM, Netherlands

Location

GSK Investigational Site

Oslo, 0027, Norway

Location

GSK Investigational Site

Oslo, 0407, Norway

Location

GSK Investigational Site

Trondheim, 7030, Norway

Location

GSK Investigational Site

Bialystok, 15-276, Poland

Location

GSK Investigational Site

Bydgoszcz, 85-326, Poland

Location

GSK Investigational Site

Bydgoszcz, 85-796, Poland

Location

GSK Investigational Site

Chęciny, 26-060, Poland

Location

GSK Investigational Site

Gdansk, 80-952, Poland

Location

GSK Investigational Site

Głuchołazy, 41-340, Poland

Location

GSK Investigational Site

Krakow, 31-202, Poland

Location

GSK Investigational Site

Lodz, 90-549, Poland

Location

GSK Investigational Site

Lodz, 93-513, Poland

Location

GSK Investigational Site

Lublin, 20-954, Poland

Location

GSK Investigational Site

Poznan, 60-569, Poland

Location

GSK Investigational Site

Rzeszów, Poland

Location

GSK Investigational Site

Szczecin, 70-891, Poland

Location

GSK Investigational Site

Warsaw, 04-125, Poland

Location

GSK Investigational Site

Wroclaw, 53-439, Poland

Location

GSK Investigational Site

Zakopane, 34-500, Poland

Location

GSK Investigational Site

Chelyabinsk, 454087, Russia

Location

GSK Investigational Site

Kazan', 420029, Russia

Location

GSK Investigational Site

Kursk, 305035, Russia

Location

GSK Investigational Site

Moscow, 115478, Russia

Location

GSK Investigational Site

Moscow, 129128, Russia

Location

GSK Investigational Site

Saint Petersburg, 197 089, Russia

Location

GSK Investigational Site

Saint Petersburg, 197758, Russia

Location

GSK Investigational Site

Saint Petersburg, 198255, Russia

Location

GSK Investigational Site

Stavropol, 355047, Russia

Location

GSK Investigational Site

Ufa, 450054, Russia

Location

GSK Investigational Site

Singapore, 119074, Singapore

Location

GSK Investigational Site

Singapore, 169610, Singapore

Location

GSK Investigational Site

Kyunggi-do, 410-769, South Korea

Location

GSK Investigational Site

Seongnam-si, 463-707, South Korea

Location

GSK Investigational Site

Seoul, 120-752, South Korea

Location

GSK Investigational Site

Seoul, 135-710, South Korea

Location

GSK Investigational Site

Seoul, 137-701, South Korea

Location

GSK Investigational Site

Seoul, 138-736, South Korea

Location

GSK Investigational Site

Barcelona, 08003, Spain

Location

GSK Investigational Site

Barcelona, 08035, Spain

Location

GSK Investigational Site

Barcelona, 08221, Spain

Location

GSK Investigational Site

Granada, 18013, Spain

Location

GSK Investigational Site

Granada, 18014, Spain

Location

GSK Investigational Site

Leganés, 28911, Spain

Location

GSK Investigational Site

Lleida, 25198, Spain

Location

GSK Investigational Site

Madrid, 28007, Spain

Location

GSK Investigational Site

Madrid, 28040, Spain

Location

GSK Investigational Site

Madrid, 28041, Spain

Location

GSK Investigational Site

Madrid, 28050, Spain

Location

GSK Investigational Site

Málaga, 29010, Spain

Location

GSK Investigational Site

Oviedo, 33006, Spain

Location

GSK Investigational Site

Sabadell, 08208, Spain

Location

GSK Investigational Site

San Sebastián de los Reyes, 28702, Spain

Location

GSK Investigational Site

Santander, 39008, Spain

Location

GSK Investigational Site

Santiago de Compostela, 15706, Spain

Location

GSK Investigational Site

Seville, 41013, Spain

Location

GSK Investigational Site

Seville, 41071, Spain

Location

GSK Investigational Site

Valencia, 46010, Spain

Location

GSK Investigational Site

Valencia, 46014, Spain

Location

GSK Investigational Site

Lund, SE-221 85, Sweden

Location

GSK Investigational Site

Stockholm, SE-171 76, Sweden

Location

GSK Investigational Site

Uppsala, SE-751 85, Sweden

Location

GSK Investigational Site

Aarau, 5001, Switzerland

Location

GSK Investigational Site

Basel, 4031, Switzerland

Location

GSK Investigational Site

Bern, 3010, Switzerland

Location

GSK Investigational Site

Bruderholz, 4101, Switzerland

Location

GSK Investigational Site

Thun, 3600, Switzerland

Location

GSK Investigational Site

Zurich, 8091, Switzerland

Location

GSK Investigational Site

Kaohsiung City, 833, Taiwan

Location

GSK Investigational Site

Taichung, 404, Taiwan

Location

GSK Investigational Site

Taichung, 40705, Taiwan

Location

GSK Investigational Site

Tainan, 704, Taiwan

Location

GSK Investigational Site

Taipei, 100, Taiwan

Location

GSK Investigational Site

Taipei, 112, Taiwan

Location

GSK Investigational Site

Taoyuan District, 333, Taiwan

Location

GSK Investigational Site

Bangkok, 10110, Thailand

Location

GSK Investigational Site

Bangkok, 10400, Thailand

Location

GSK Investigational Site

Chiang Mai, 50200, Thailand

Location

GSK Investigational Site

Hat Yai, 90110, Thailand

Location

GSK Investigational Site

Dnipropetrovsk, 49102, Ukraine

Location

GSK Investigational Site

Donetsk, 83092, Ukraine

Location

GSK Investigational Site

Kharkiv, 61070, Ukraine

Location

GSK Investigational Site

Kyiv, 01113, Ukraine

Location

GSK Investigational Site

Kyiv, 03115, Ukraine

Location

GSK Investigational Site

Kyiv, 04107, Ukraine

Location

GSK Investigational Site

Lviv, 79031, Ukraine

Location

GSK Investigational Site

Odesa, 65117, Ukraine

Location

GSK Investigational Site

Simferopol, 95023, Ukraine

Location

GSK Investigational Site

Uzhhorod, 88017, Ukraine

Location

GSK Investigational Site

Vinnytsia, 21029, Ukraine

Location

GSK Investigational Site

Cambridge, Cambridgeshire, CB2 2RE, United Kingdom

Location

GSK Investigational Site

Wythenshawe, Greater Manchester, M23 9LT, United Kingdom

Location

GSK Investigational Site

Leicester, Leicestershire, LE1 5WW, United Kingdom

Location

GSK Investigational Site

Edinburgh, Midlothian, EH4 2XU, United Kingdom

Location

GSK Investigational Site

Sutton, Surrey, SM2 5PT, United Kingdom

Location

GSK Investigational Site

Aberdeen, AB25 2ZN, United Kingdom

Location

GSK Investigational Site

Bebington, CH63 4JY, United Kingdom

Location

GSK Investigational Site

Belfast, BT9 7AB, United Kingdom

Location

GSK Investigational Site

Birmingham, B9 5SS, United Kingdom

Location

GSK Investigational Site

Cambridge, CB23 3RE, United Kingdom

Location

GSK Investigational Site

Dundee, DD1 9SY, United Kingdom

Location

GSK Investigational Site

Glasgow, G12 0YN, United Kingdom

Location

GSK Investigational Site

Inverness, IV2 3UJ, United Kingdom

Location

GSK Investigational Site

Leeds, LS9 7TF, United Kingdom

Location

GSK Investigational Site

Liverpool, L14 3PE, United Kingdom

Location

GSK Investigational Site

London, SE1 9RT, United Kingdom

Location

GSK Investigational Site

London, SW3 6JJ, United Kingdom

Location

GSK Investigational Site

London, SW3 6NP, United Kingdom

Location

GSK Investigational Site

Maidstone, ME16 9QQ, United Kingdom

Location

GSK Investigational Site

Sheffield, S10 2SJ, United Kingdom

Location

Related Publications (3)

  • Vansteenkiste JF, Cho BC, Vanakesa T, De Pas T, Zielinski M, Kim MS, Jassem J, Yoshimura M, Dahabreh J, Nakayama H, Havel L, Kondo H, Mitsudomi T, Zarogoulidis K, Gladkov OA, Udud K, Tada H, Hoffman H, Bugge A, Taylor P, Gonzalez EE, Liao ML, He J, Pujol JL, Louahed J, Debois M, Brichard V, Debruyne C, Therasse P, Altorki N. Efficacy of the MAGE-A3 cancer immunotherapeutic as adjuvant therapy in patients with resected MAGE-A3-positive non-small-cell lung cancer (MAGRIT): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2016 Jun;17(6):822-835. doi: 10.1016/S1470-2045(16)00099-1. Epub 2016 Apr 27.

    PMID: 27132212BACKGROUND
  • Dizier B, Callegaro A, Debois M, Dreno B, Hersey P, Gogas HJ, Kirkwood JM, Vansteenkiste JF, Sequist LV, Atanackovic D, Goeman J, van Houwelingen H, Salceda S, Wang F, Therasse P, Debruyne C, Spiessens B, Brichard VG, Louahed J, Ulloa-Montoya F. A Th1/IFNgamma Gene Signature Is Prognostic in the Adjuvant Setting of Resectable High-Risk Melanoma but Not in Non-Small Cell Lung Cancer. Clin Cancer Res. 2020 Apr 1;26(7):1725-1735. doi: 10.1158/1078-0432.CCR-18-3717. Epub 2019 Nov 15.

    PMID: 31732522BACKGROUND
  • Zhu J, Yuan Y, Wan X, Yin D, Li R, Chen W, Suo C, Song H. Immunotherapy (excluding checkpoint inhibitors) for stage I to III non-small cell lung cancer treated with surgery or radiotherapy with curative intent. Cochrane Database Syst Rev. 2021 Dec 6;12(12):CD011300. doi: 10.1002/14651858.CD011300.pub3.

Related Links

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell Lung

Condition Hierarchy (Ancestors)

Carcinoma, BronchogenicBronchial NeoplasmsLung NeoplasmsRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract Diseases

Results Point of Contact

Title
GSK Response Center
Organization
GlaxoSmithKline

Study Officials

  • GSK Clinical Trials

    GlaxoSmithKline

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 29, 2007

First Posted

May 30, 2007

Study Start

October 4, 2007

Primary Completion

December 6, 2013

Study Completion

September 23, 2014

Last Updated

December 22, 2020

Results First Posted

January 30, 2019

Record last verified: 2020-11

Data Sharing

IPD Sharing
Will share

IPD for this study is available via the Clinical Study Data Request site.

Shared Documents
STUDY PROTOCOL, SAP, ICF, CSR
Time Frame
IPD is available via the Clinical Study Data Request site (click on the link provided below)
Access Criteria
Access is provided after a research proposal is submitted and has received approval from the Independent Review Panel and after a Data Sharing Agreement is in place. Access is provided for an initial period of 12 months but an extension can be granted, when justified, for up to another 12 months.
More information

Available IPD Datasets

Individual Participant Data Set (109493)Access
Informed Consent Form (109493)Access
Study Protocol (109493)Access
Clinical Study Report (109493)Access
Statistical Analysis Plan (109493)Access
Annotated Case Report Form (109493)Access
Dataset Specification (109493)Access

Locations