Sweetened Beverages and Food Intake

NCT00475475 | Completed

• 2 other identifiers: 28740-A05-8515-A 03
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate whether beverages sweetened with fructose promote overconsumption of calories as compared to beverages sweetened with glucose or a non-caloric sweetener.

Conditions

Overweight; Obesity

Keywords

Overweight; Obesity; Appetite; Dietary sugars; Fructose; Glucose; Leptin; Insulin; Ghrelin

Outcome Measures

Primary Outcomes (1)

• Total energy consumed in the three diet periods.

  8 days in each period

Secondary Outcomes (4)

• Resting energy expenditure

  After 8 days of each dietary phase

• Fasting and postprandial plasma concentrations of satiety and adiposity signals.

  After 8 days of each dietary phase

• Fasting and postprandial plasma lipid and lipoprotein concentrations.

  After 8 days of each dietary phase

• Fasting plasma concentrations of inflammatory mediators.

  After 8 days of each dietary phase

Study Arms (3)

1

EXPERIMENTAL

Fructose-sweetened beverage Subjects will be asked to drink 4 servings of a beverage sweetened with 100% fructose per day for 8 days, while consuming an ad libitum diet (same solid food for all three diet periods).

Behavioral: Fructose

2

EXPERIMENTAL

Glucose-sweetened beverage Subjects will be asked to drink 4 servings of a beverage sweetened with 100% glucose per day for 8 days, while consuming an ad libitum diet (same solid food for all three diet periods).

Behavioral: glucose

3

PLACEBO COMPARATOR

Beverage sweetened with a non-caloric sweetener Subjects will be asked to drink 4 servings of a beverage sweetened with a non-caloric sweetener per day for 8 days, while consuming an ad libitum diet (same solid food for all three diet periods).

Behavioral: non-caloric sweetener

Interventions

Fructose BEHAVIORAL

25% of energy intake in the form of a fructose-sweetened beverage (arm 1), a glucose-sweetened beverage (arm 2), or an isovolumetric amount of a beverage sweetened with a non-caloric sweetener

1

glucose BEHAVIORAL

25% of energy intake in the form of a fructose-sweetened beverage (arm 1), a glucose-sweetened beverage (arm 2), or an isovolumetric amount of a beverage sweetened with a non-caloric sweetener

2

non-caloric sweetener BEHAVIORAL

25% of energy intake in the form of a fructose-sweetened beverage (arm 1), a glucose-sweetened beverage (arm 2), or an isovolumetric amount of a beverage sweetened with a non-caloric sweetener

3

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age: 18-25 years
• Body mass index: 20-25 kg/m2
• Weight stable to within 5 pounds for 6 months prior to entering the study
• Within 10 pounds of their lifetime maximum weight
• Ability to be admitted for 5 hours to the General Clinical Research Center of the University of Washington on three occasions
• Ability to provide informed written consent
• Willingness to consume only food provided by the Nutrition Research Kitchen of the University of Washington General Clinical Research Center for three periods of 8 days each

You may not qualify if:

• History of cardiovascular disease
• Presence of diabetes mellitus or impaired glucose tolerance (fasting glucose \> 100 mg/dL)
• Presence of hypertension (blood pressure systolic/diastolic higher than 140/90)
• Presence of phenylketonuria
• Presence of fructose malabsorption or hereditary fructose intolerance
• Presence of another chronic or psychiatric illness
• Use of anabolic steroids, glucocorticoids, warfarin, beta-blockers, antidepressants, or lipid-lowering agents
• Use of antibiotic drugs within 3 months of enrollment into the study
• Use of tobacco products
• Pregnancy or female subject not using contraception
• Regular intense exercise (\> 3 hour per week)
• Vegetarian or extreme dietary preferences
• Alcohol consumption of more than 2 drinks per day
• Presence of eating disorder
• History of frequent attempts at weight loss

Sponsors & Collaborators

• University of Washington: lead
• Seattle Children's Hospital: collaborator

Study Sites (1)

University of Washington General Clinical Research Center

Seattle, Washington, 98195, United States

Location

Related Publications (1)

• Kuzma JN, Cromer G, Hagman DK, Breymeyer KL, Roth CL, Foster-Schubert KE, Holte SE, Callahan HS, Weigle DS, Kratz M. No difference in ad libitum energy intake in healthy men and women consuming beverages sweetened with fructose, glucose, or high-fructose corn syrup: a randomized trial. Am J Clin Nutr. 2015 Dec;102(6):1373-80. doi: 10.3945/ajcn.115.116368. Epub 2015 Nov 4.

  PMID: 26537945 DERIVED

MeSH Terms

Conditions

Overweight; Obesity; Insulin Resistance

Interventions

Fructose; Glucose

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases

Intervention Hierarchy (Ancestors)

Hexoses; Monosaccharides; Sugars; Carbohydrates; Ketoses

Study Officials

• Mario Kratz, Ph.D.

  University of Washington

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant Professor

Study Record Dates

• First Submitted: May 16, 2007
• First Posted: May 21, 2007
• Study Start: May 1, 2007
• Primary Completion: December 1, 2011
• Study Completion: December 1, 2011
• Last Updated: May 2, 2012

Record last verified: 2012-04

Locations

US (1)