Effect of Coca-Cola on Iron Absorption

NCT00474500 | Completed DMC

• 1 other identifier: IFR13/2006
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this project is to measure the effect of Coca-Cola and Diet Coke, relative to mineral water, on non-haem iron absorption. The results from this study will quantify any enhancing effect of Coca-Cola or Diet Coke on non-haem iron absorption and will be of use to the Coca-Cola Company and the scientific and nutrition community in evaluating the nutritional value of these products.

Conditions

Iron Deficiency

Keywords

Iron absorption; Coca-Cola

Outcome Measures

Primary Outcomes (1)

• Non-haem iron absorption

  1 year

Interventions

Coca, Cola, Diet Coke DRUG

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Women
• Age \> 18 and \< 65

You may not qualify if:

• Men
• Age \< 18 or \> 65
• BMI \<18.5 or \> 35
• Serum ferritin value of \<12 or \>50µg/L (±10% to allow for day to day and analytical variation)
• Volunteers will be excluded if they are found to have depressed or elevated blood pressure measurements (\<90/50 or \<95/55 if symptomatic or \>160/100)
• Diagnosed with a long-term illness requiring active treatment, e.g. diabetes, cancer, cardiovascular disease.
• Gastrointestinal disease (excluding hiatus hernia unless symptomatic or study intervention/procedure is contraindicated)
• Regular prescribed medication that may interfere with iron metabolism
• Regular use of antacids and laxatives (at least once a week)
• Women who are pregnant or less than 12 months since giving birth
• Women breast feeding
• Vitamin supplements with or without minerals if taken more than once a week, and unwillingness to discontinue occasional use for the duration of study
• Unwillingness to discontinue use of herbal supplements for the duration of study
• Use of antibiotics within four weeks prior to study start
• Parallel participation in another study which involves dietary interventions or sampling of blood that may increase the volume taken above 500ml in a 4-month period

Sponsors & Collaborators

• Quadram Institute Bioscience: lead
• University of East Anglia: collaborator
• The Coca-Cola Company: collaborator

Study Sites (1)

Institute of Food Research

Norwich, Norfolk, NR4 6JF, United Kingdom

Location

Related Publications (1)

• Collings R, Fairweather-Tait SJ, Dainty JR, Roe MA. Low-pH cola beverages do not affect women's iron absorption from a vegetarian meal. J Nutr. 2011 May;141(5):805-8. doi: 10.3945/jn.110.136507. Epub 2011 Mar 9.

  PMID: 21389184 DERIVED

MeSH Terms

Conditions

Iron Deficiencies

Interventions

Cocaine

Condition Hierarchy (Ancestors)

Iron Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Tropanes; Azabicyclo Compounds; Aza Compounds; Organic Chemicals; Alkaloids; Heterocyclic Compounds; Bridged Bicyclo Compounds, Heterocyclic; Heterocyclic Compounds, Bridged-Ring

Study Officials

• Susan J Fairweather-Tait

  University of East Anglia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 16, 2007
• First Posted: May 17, 2007
• Study Start: May 1, 2007
• Primary Completion: May 1, 2009
• Study Completion: May 1, 2010
• Last Updated: March 17, 2011

Record last verified: 2011-03

Locations

GB (1)