Partial Double-Blind, Placebo-Controlled Study to Assess the Effect of Anastrozole on the Endometrium in Healthy Volunteers

NCT00467493 | Completed Phase 2

• 1 other identifier: M-001
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 2

Brief Summary

Aromatase inhibitors have been approved for use in postmenopausal women to treat and prevent breast cancer. They act by blocking the action of the enzyme, aromatase, that is necessary for the production of estradiol. This class of drugs, aromatase inhibitors, are very effective in reducing estradiol levels in postmenopausal women and in treating estrogen receptor positive breast cancers. This study is examining the effect of a specific inhibitor, anastrozole, on endometrial thickness in premenopausal women. The endometrium is sensitive to estradiol and also has local aromatase which, if inhibited, may result in reduced endometrial thickness. The main hypothesis is that anastrozole can be administered at any time during the menstrual cycle and reduce endometrial thickness compared to placebo.

Conditions

Menstruation Disorders

Outcome Measures

Primary Outcomes (1)

• Endometrial thickness as measured by transvaginal ultrasound, safety

  Over one menstrual cycle

Study Arms (6)

Anastrozole - A

EXPERIMENTAL

Treatment for 26 consecutive days

Drug: Anastrozole

Anastrozole -B

EXPERIMENTAL

Treatment for 7 consecutive days early in menstrual cycle

Drug: Anastrozole

Anastrozoe - C

EXPERIMENTAL

Treatment for 7 consecutive days mid follicular phase

Drug: Anastrozole

Anastrozole - D

EXPERIMENTAL

Treatment for 7 consecutive days - mid cycle

Drug: Anastrozole

Anastrozole - E

EXPERIMENTAL

Treatment for 7 consecutive days - luteal

Drug: Anastrozole

Anastrozole - F

PLACEBO COMPARATOR

Treatment with placebo for 26 consecutive days

Drug: Anastrozole

Interventions

Anastrozole DRUG

Anastrozoe - C; Anastrozole - A; Anastrozole - D; Anastrozole - E; Anastrozole - F; Anastrozole -B

Eligibility Criteria

• Age: 25 Years - 45 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Between the ages of 25 and 45 and pre-menopausal;
• Non-lactating and not pregnant
• able to follow the schedule of procedures
• able to freely provide informed consent
• have clinically acceptable physical examination and safety laboratory studies

You may not qualify if:

• current use of any form of systemic contraceptive
• have self-reported irregular menstrual cycles
• intercurrent illness(es) detected on the screening physical
• unwilling or unable to use barrier methods of contraception
• have evidence of endometrial polyps or myomata on TVU/SIS that would interfere with endometrial thickness measurement
• detection of ovarian cyst(s) during adnexal examination on screening TVU/SIS measuring greater than 5 cm
• have history of, or current cancer, on any form exclusive of basal cell carcinoma
• BMI \>= 35
• history of alcohol or drug abuse in the past 5 years
• unwilling or unable to undergo study procedures within the necessary time frames
• history or current liver abnormalities as defined by ALT or AST \> 2X ULN
• treated or untreated diabetes defined as fasting blood sugar \>= 126 mg/dL
• untreated hypertension
• impaired renal function by estimated creatinine clearance \< 80mL/min
• have estradiol levels \< 20 pg/ml and FSH levels \> 40 mIU/mL or

Sponsors & Collaborators

• Meditrina Pharmaceuticals: lead

Study Sites (2)

Jasper Research Clinic

Kalamazoo, Michigan, 49007, United States

Location

University Women's Care

Southfield, Michigan, 48034, United States

Location

MeSH Terms

Conditions

Menstruation Disturbances

Interventions

Anastrozole

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Nitriles; Organic Chemicals; Triazoles; Azoles; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY

Study Record Dates

• First Submitted: April 27, 2007
• First Posted: April 30, 2007
• Study Start: March 1, 2007
• Primary Completion: September 1, 2007
• Study Completion: September 1, 2007
• Last Updated: June 3, 2009

Record last verified: 2009-06

Locations

US (2)