NCT00464282

Brief Summary

Objective: L-\[3-18F\]-α-methyltyrosine (FMT) is an amino-acid tracer for PET. We evaluated the diagnostic usefulness of 18F-FMT PET in non-small cell lung cancer (NSCLC) patients. Tumor uptake of 18F-FMT PET was compared with 18F-FDG PET and the correlation with L-type amino acid transporter 1 (LAT1) expression also investigated. Method: Fifty patients with NSCLC were enrolled in this study, and a pair of PET study with 18F-FMT and 18F-FDG was performed. LAT1 expression and Ki-67 labeling index of the resected tumors were analyzed by immunohistochemical study.

Trial Health

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 20, 2007

Completed
3 days until next milestone

First Posted

Study publicly available on registry

April 23, 2007

Completed
Last Updated

April 23, 2007

Status Verified

April 1, 2007

First QC Date

April 20, 2007

Last Update Submit

April 20, 2007

Conditions

Carcinoma, Non-Small-Cell Lung

Keywords

Fluorine-18-α-methyltyrosine,Positron emission tomography,FluorodeoxyglucoseLung cancer,Amino acid transportor 1,Ki-67Proven or suspected non-small cell lung cancer were enrolled in the study

Eligibility Criteria

Age8 Months - 2 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • proven or suspected non-small cell lung cancer

You may not qualify if:

  • uncontrolled diabetes mellitus

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Kaira K, Oriuchi N, Shimizu K, Tominaga H, Yanagitani N, Sunaga N, Ishizuka T, Kanai Y, Mori M, Endo K. 18F-FMT uptake seen within primary cancer on PET helps predict outcome of non-small cell lung cancer. J Nucl Med. 2009 Nov;50(11):1770-6. doi: 10.2967/jnumed.109.066837. Epub 2009 Oct 16.

    PMID: 19837768DERIVED

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell LungLung Neoplasms

Condition Hierarchy (Ancestors)

Carcinoma, BronchogenicBronchial NeoplasmsRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract Diseases

Study Officials

  • kyoichi kaira, MD

    Gunma Unversity Graduate School of Medicine

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
DEFINED POPULATION
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

April 20, 2007

First Posted

April 23, 2007

Last Updated

April 23, 2007

Record last verified: 2007-04