NCT00449215

Brief Summary

The genetic bases of peak bone mass in males, as determinants of an individual's risk of developing osteoporotic fractures in old age and their interaction with dietary and lifestyle factors are still poorly understood. Our objective was to examine the relative contribution of genetic and environmental variables to the regulation of peak bone mass in a population-based cohort of young healthy men, focusing on the BsmI polymorphism of vitamin D receptor (VDR)gene and the AluI polymorphism of calcitonin receptor (CTR)gene.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
301

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Oct 2004

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2004

Completed
2.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2006

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

March 18, 2007

Completed
2 days until next milestone

First Posted

Study publicly available on registry

March 20, 2007

Completed
Last Updated

March 20, 2007

Status Verified

March 1, 2007

First QC Date

March 18, 2007

Last Update Submit

March 18, 2007

Conditions

Osteoporosis

Keywords

Peak Bone Mass; Male; Genetic Polymorphisms

Eligibility Criteria

Age16 Years - 35 Years
Sexmale
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Greek healthy young men

You may not qualify if:

  • Men who were treated with corticosteroids, anticonvulsants, or anticoagulants or who suffered from hypogonadism, kidney, liver, thyroid and gastrointestinal disease or diabetes mellitus were excluded from the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Laboratory for Research of Musculoskeletal System, University of Athens

Athens, 14561, Greece

Location

Related Publications (1)

  • Gunnes M, Berg JP, Halse J, Lehmann EH. Lack of relationship between vitamin D receptor genotype and forearm bone gain in healthy children, adolescents, and young adults. J Clin Endocrinol Metab. 1997 Mar;82(3):851-5. doi: 10.1210/jcem.82.3.3814.

    PMID: 9062495BACKGROUND

MeSH Terms

Conditions

Osteoporosis

Condition Hierarchy (Ancestors)

Bone Diseases, MetabolicBone DiseasesMusculoskeletal DiseasesMetabolic DiseasesNutritional and Metabolic Diseases

Study Officials

  • Ioannis N Charopoulos, M.D

    Laboratory Of Research Of Musculoskeletal System

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
DEFINED POPULATION
Time Perspective
OTHER
Sponsor Type
OTHER

Study Record Dates

First Submitted

March 18, 2007

First Posted

March 20, 2007

Study Start

October 1, 2004

Study Completion

December 1, 2006

Last Updated

March 20, 2007

Record last verified: 2007-03

Locations

GR(1)