Abdominal Adiposity and Muscle Mitochondrial Functions

NCT00446745 | Completed

• 1 other identifier: AU628
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Numerous studies have demonstrated that excess perivisceral adipose tissue is associated with metabolic diseases such as insulin resistance. In skeletal muscle, insulin resistance has been correlated with reduced mitochondrial oxidative functions. According to the actual theory, mitochondrial dysfunctions are proposed to play a causal role in the aetiology of insulin resistance. Mechanisms involve increased intramyocellular lipids storage. Yet, the causes responsible for the decline in muscle mitochondrial functions remain to be elucidated. The investigators hypothesize that these alterations are induced by combined changes in plasma profiles of lipids and adipokines, which originate from perivisceral adipose tissue. The study aims at answering the following questions :

• Are muscle mitochondrial functions altered in association with increased perivisceral adipose tissue storage?
• Do changes in the pattern of plasma lipids and adipokines explain this correlation?

Conditions

Mitochondrial Respiratory Chain Deficiencies

Keywords

Nutritional and Metabolic Diseases; Insulin resistance; Energy Metabolisms; Skeletal muscle; Visceral Adipose Tissue

Study Arms (1)

Abdominal obesity

60 males were recruited according to waist circumference, from lean to obese values

Eligibility Criteria

• Age: 35 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

* 60 Male subjects * Age between 35 and 50 * waist circumference (Waist) \> 75 cm 15 men with Waist between 75 and \<87cm, 15 men with Waist between 87 and \<94cm, 15 men with Waist between 94 and \<102cm, and 15 men with Waith equal or higher than 102cm.

You may qualify if:

• Male subjects
• Age between 35 and 50
• waist circumference \> 75 cm
• Baecke score \< 1 (activity score for sedentary subjects)
• Subjects giving written informed consent
• Subjects willing to comply with the study procedures
• Subjects considered as normal after clinical examination and medical questionnaire

You may not qualify if:

• Weight change \> 3 kg within 3 months prior to study
• Patients with type 1 or type 2 diabetes
• Serologic evidence of active hepatitis B or HIV
• History of cancer or significant intestinal, hepatic, renal or cardiovascular disorders within the past 5 years
• History of systemic infections or inflammatory diseases within the past 2 months
• Hypocaloric or special diets (e.g. vegetarian)
• Patients currently known to abuse or to be dependent on any drug, including alcohol (daily consumption \> 20g) and tobacco (daily consumption \> 5 cigarettes)
• CRP \< 5 mg/L
• Blood coagulation disorders
• Allergy to xylocaïne
• for test meal : Food allergy (particularly milk allergy and lactose intolerance)
• for MRI : Claustrophobia

Sponsors & Collaborators

• Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement: lead

Study Sites (1)

Centre ed Recherche en Nutrition Humaine d'Auvergne (CRNH), Unité d'Exploration Nutritionnelle, Laboratoire de Nutrition humaine

Clermont-Ferrand, 63009 cedex 1, France

Location

Related Publications (3)

• Chanseaume E, Tardy AL, Salles J, Giraudet C, Rousset P, Tissandier A, Boirie Y, Morio B. Chronological approach of diet-induced alterations in muscle mitochondrial functions in rats. Obesity (Silver Spring). 2007 Jan;15(1):50-9. doi: 10.1038/oby.2007.511.

  PMID: 17228031 BACKGROUND

• Chanseaume E, Malpuech-Brugere C, Patrac V, Bielicki G, Rousset P, Couturier K, Salles J, Renou JP, Boirie Y, Morio B. Diets high in sugar, fat, and energy induce muscle type-specific adaptations in mitochondrial functions in rats. J Nutr. 2006 Aug;136(8):2194-200. doi: 10.1093/jn/136.8.2194.

  PMID: 16857840 BACKGROUND

• Chanseaume E, Barquissau V, Salles J, Aucouturier J, Patrac V, Giraudet C, Gryson C, Duche P, Boirie Y, Chardigny JM, Morio B. Muscle mitochondrial oxidative phosphorylation activity, but not content, is altered with abdominal obesity in sedentary men: synergism with changes in insulin sensitivity. J Clin Endocrinol Metab. 2010 Jun;95(6):2948-56. doi: 10.1210/jc.2009-1938. Epub 2010 Apr 9.

  PMID: 20382691 DERIVED

MeSH Terms

Conditions

Mitochondrial Diseases; Nutritional and Metabolic Diseases; Insulin Resistance

Condition Hierarchy (Ancestors)

Metabolic Diseases; Hyperinsulinism; Glucose Metabolism Disorders

Study Officials

• Yves Boirie, PU-PH

  UMR1019 INRA - Auvergne University

  PRINCIPAL INVESTIGATOR

• Beatrice Morio, PhD

  UMR 1019 INRA - Auvergne University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: March 9, 2007
• First Posted: March 13, 2007
• Study Start: April 1, 2006
• Primary Completion: December 1, 2006
• Study Completion: January 1, 2007
• Last Updated: September 19, 2012

Record last verified: 2012-09

Locations

FR (1)