NCT00446745|Completed
Abdominal Adiposity and Muscle Mitochondrial Functions
Mithycal
Study of Interaction Between Adipose and Muscle Tissues in the Control of Muscle Mitochondrial Functions
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Mithycal
Study of Interaction Between Adipose and Muscle Tissues in the Control of Muscle Mitochondrial Functions
Sponsor study identifier
observational
60
1 country
1
Study Start
April 2006
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2006
Actual (reported)Study Completion
January 2007
Actual (reported)Numerous studies have demonstrated that excess perivisceral adipose tissue is associated with metabolic diseases such as insulin resistance. In skeletal muscle, insulin resistance has been correlated with reduced mitochondrial oxidative functions. According to the actual theory, mitochondrial dysfunctions are proposed to play a causal role in the aetiology of insulin resistance. Mechanisms involve increased intramyocellular lipids storage. Yet, the causes responsible for the decline in muscle mitochondrial functions remain to be elucidated. The investigators hypothesize that these alterations are induced by combined changes in plasma profiles of lipids and adipokines, which originate from perivisceral adipose tissue. The study aims at answering the following questions :
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 2007
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 2006
Date type not reportedThis date has not been verified as actual or estimated.
December 2006
Actual (reported)January 2007
Actual (reported)March 9, 2007
Actual (reported)March 13, 2007
Actual (reported)60 males were recruited according to waist circumference, from lean to obese values
* 60 Male subjects * Age between 35 and 50 * waist circumference (Waist) \> 75 cm 15 men with Waist between 75 and \<87cm, 15 men with Waist between 87 and \<94cm, 15 men with Waist between 94 and \<102cm, and 15 men with Waith equal or higher than 102cm.
Centre ed Recherche en Nutrition Humaine d'Auvergne (CRNH), Unité d'Exploration Nutritionnelle, Laboratoire de Nutrition humaine
Clermont-Ferrand, 63009 cedex 1, France
Chanseaume E, Tardy AL, Salles J, Giraudet C, Rousset P, Tissandier A, Boirie Y, Morio B. Chronological approach of diet-induced alterations in muscle mitochondrial functions in rats. Obesity (Silver Spring). 2007 Jan;15(1):50-9. doi: 10.1038/oby.2007.511.
Chanseaume E, Malpuech-Brugere C, Patrac V, Bielicki G, Rousset P, Couturier K, Salles J, Renou JP, Boirie Y, Morio B. Diets high in sugar, fat, and energy induce muscle type-specific adaptations in mitochondrial functions in rats. J Nutr. 2006 Aug;136(8):2194-200. doi: 10.1093/jn/136.8.2194.
Yves Boirie, PU-PH
UMR1019 INRA - Auvergne University
Beatrice Morio, PhD
UMR 1019 INRA - Auvergne University
60 participants (actual enrollment reported by the registry).
First Submitted
March 9, 2007
First Posted
March 13, 2007
Study Start
April 2006
Date type not reportedThis date has not been verified as actual or estimated.
Contact the study team to confirm eligibility.
Chanseaume E, Barquissau V, Salles J, Aucouturier J, Patrac V, Giraudet C, Gryson C, Duche P, Boirie Y, Chardigny JM, Morio B. Muscle mitochondrial oxidative phosphorylation activity, but not content, is altered with abdominal obesity in sedentary men: synergism with changes in insulin sensitivity. J Clin Endocrinol Metab. 2010 Jun;95(6):2948-56. doi: 10.1210/jc.2009-1938. Epub 2010 Apr 9.
Primary Completion
December 2006
Actual (reported)Study Completion
January 2007
Actual (reported)Last Updated
September 19, 2012
Record last verified: 2012-09
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Source: ClinicalTrials.gov.
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