Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane
1 other identifier
interventional
300
2 countries
4
Brief Summary
We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_4
Started Aug 2006
4 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2006
CompletedFirst Submitted
Initial submission to the registry
March 8, 2007
CompletedFirst Posted
Study publicly available on registry
March 12, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2008
CompletedMay 30, 2013
May 1, 2013
1.9 years
March 8, 2007
May 28, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire
recovery room stay
Study Arms (2)
1
ACTIVE COMPARATORPropofol based anaesthetic maintenance with propofol effect-site steered target-controlled infusion, in addition to fentanyl and non-opioid analgesics
2
ACTIVE COMPARATORDesflurane based anaesthetic maintenance with manually controlled administration in 100% oxygen in addition to fentanyl and non-opioid analgesics
Interventions
Eligibility Criteria
You may qualify if:
- Male and female patients
- Age between 18 and 50 years
- Presenting for elective surgery under general anaesthesia
You may not qualify if:
- Inadequate English language comprehension
- Major drug abuse problem
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Melbourne Healthlead
Study Sites (4)
Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
Royal Perth Hospital
Perth, Western Australia, 6000, Australia
King Edward Memorial Hospital for Women
Subiaco, Western Australia, 6008, Australia
Waikato Hospital
Hamilton, New Zealand
Related Publications (2)
Liang Z, Wang Y, Ren Y, Li D, Voss L, Sleigh J, Li X. Detection of burst suppression patterns in EEG using recurrence rate. ScientificWorldJournal. 2014;2014:295070. doi: 10.1155/2014/295070. Epub 2014 Apr 17.
PMID: 24883378DERIVEDLeslie K, Sleigh J, Paech MJ, Voss L, Lim CW, Sleigh C. Dreaming and electroencephalographic changes during anesthesia maintained with propofol or desflurane. Anesthesiology. 2009 Sep;111(3):547-55. doi: 10.1097/ALN.0b013e3181adf768.
PMID: 19672164DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Kate Leslie, MD
Melbourne Health
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- DIAGNOSTIC
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 8, 2007
First Posted
March 12, 2007
Study Start
August 1, 2006
Primary Completion
July 1, 2008
Study Completion
July 1, 2008
Last Updated
May 30, 2013
Record last verified: 2013-05