The Effects of Trout Fed With a Vegetable Based Feed on Cardiovascular Risk Markers and Plasma Proteome

NCT00445614 | Completed

• 1 other identifier: M187
• Study Type: interventional
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

Fish from the aquaculture sector constitutes an increasing part of the fish consumption in Denmark. The most important farmed fish in Denmark is the rainbow trout. Due to limited access of wild fish for the feed production, alternative feeding regimes of vegetable origin such as vegetable proteins and rapeseed oil are used instead of marine feed. This change in feeding regime may affect flesh quality and health and nutritional properties as the content of long-chain n-3 polyunsaturated fatty acids (n-3 LCPUFA) will presumably decrease in the meat. The objective of the study is to investigate the effect of vegetable based feed versus marine feed of farmed trout and its effect in healthy men on cardiovascular risk markers associated with the development of cardiovascular disease (CVD).

Conditions

Cardiovascular Disease

Keywords

nutrition; cardiovascular risk; inflammation; vascular function

Outcome Measures

Primary Outcomes (7)

• plasma protein expression

• blood pressure

• pulse wave analysis

• pulse wave velocity

• cardiovascular risk markers

• markers of inflammation

• plasma lipids

Study Arms (3)

Marine trout

EXPERIMENTAL

150 g/day of trout fed on marine based feed

Behavioral: Effects of trout on CVD risk markers and plasma proteome

Vegetable trout

EXPERIMENTAL

150 g/d of trout fed on vegetable based feed

Behavioral: Effects of trout on CVD risk markers and plasma proteome

Poultry

OTHER

150 g/d of poultry (for comparison)

Behavioral: Effects of trout on CVD risk markers and plasma proteome

Interventions

Effects of trout on CVD risk markers and plasma proteome BEHAVIORAL

Marine trout; Poultry; Vegetable trout

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 40-70
• Body mass index 18,5 - 30

You may not qualify if:

• Exercise \>10 h/week
• Chronical diseases (eg. cardiovascular and diabetes)
• Regular medication
• Fish oil supplementation
• Blood donation 2 month prior or during participation
• Above maximum recommended alcohol intake
• Blood pressure \>160/100 mm Hg

Sponsors & Collaborators

• University of Copenhagen: lead
• The Ministry of Science, Technology and Innovation, Denmark: collaborator
• Danish Institute of Fisheries Research: collaborator

Study Sites (1)

Department of Human Nutrition, Denmark

Frederiksberg, Frederiksberg, 1958, Denmark

Location

MeSH Terms

Conditions

Cardiovascular Diseases; Inflammation

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Lotte Lauritzen, ph.d.

  University of Copenhagen

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: March 8, 2007
• First Posted: March 9, 2007
• Study Start: March 1, 2007
• Primary Completion: December 1, 2007
• Study Completion: December 1, 2007
• Last Updated: August 14, 2008

Record last verified: 2008-08

Locations

DK (1)