Acute Single Meal Effects of Trout on Cardiovascular Risk Markers and Plasma Proteome
1 other identifier
interventional
6
1 country
1
Brief Summary
The acute effects of farmed rainbow trout, fed by various feeds versus a control meal with poultry meat on cardiovascular risk markers and plasma protein expression are investigated. The hypotheses of the study are that if the feed are changed from a marine origin to primarily a vegetable origin the content of long chain n-3 poly unsaturated fatty acids (n-3 PUFA) will decrease in the meat and thus possibly result in a decreased effect on health. Furthermore, the feed of the trouts are also expected to give rise to differences in the human plasma protein profile and fatty acid composition after consumption, which could be associated with physiological effects.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable cardiovascular-diseases
Started Jan 2007
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2007
CompletedFirst Submitted
Initial submission to the registry
February 7, 2007
CompletedFirst Posted
Study publicly available on registry
February 8, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2009
CompletedAugust 13, 2008
August 1, 2008
2 months
February 7, 2007
August 12, 2008
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
plasma protein expression
Blood Pressure
Pulse Wave Analysis
Pulse wave Velocity
Secondary Outcomes (1)
Plasma Triglycerides
Interventions
Eligibility Criteria
You may qualify if:
- Non regular smokers
- Body Mass Index (18.5-30 kg/m2)
- Able to eat fish
You may not qualify if:
- Exercise \>10 h/week
- Chronical diseases (eg. cardiovascular and diabetes)
- Regular medication
- Fish oil supplementation
- Blood donation 2 month prior or during participation
- Above maximum recommended alcohol intake
- Blood pressure \>160/100 mm Hg
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Copenhagenlead
- Danish Institute of Fisheries Researchcollaborator
Study Sites (1)
Institute of Human Nutrition, University of Copenhagen
Frederiksberg C, 1958, Denmark
Related Publications (1)
Rentsch ML, Lametsch R, Bugel S, Jessen F, Lauritzen L. The effects of eating marine- or vegetable-fed farmed trout on the human plasma proteome profiles of healthy men. Br J Nutr. 2015 Feb 28;113(4):699-707. doi: 10.1017/S0007114514004152. Epub 2015 Jan 27.
PMID: 25622825DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Lotte Lauritzen, Ph.D
University of Copenhagen
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
February 7, 2007
First Posted
February 8, 2007
Study Start
January 1, 2007
Primary Completion
March 1, 2007
Study Completion
January 1, 2009
Last Updated
August 13, 2008
Record last verified: 2008-08