Outpatient Adolescent Treatment for Comorbid Substance Use and Internalizing Disorders

NCT00438685 | Completed Phase 1

• 2 other identifiers: 1R21DA017118-01R21DA017118
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Adolescent substance abuse results in significant negative outcomes and extraordinary costs for youths, their families, communities, and society. Moreover, rates of psychiatric comorbidity among substance abusing youth range from 25% up to 82%, and youths with a dual diagnosis have worse outcomes and are more than twice as costly to treat than their counterparts with no comorbidity. This project was a pilot test of a new treatment, OPTION-A, which was adapted from Multisystemic Therapist (MST) and other evidence-based interventions to specifically treat youth presenting for outpatient treatment of comorbid substance use and internalizing disorders. The project was a randomized controlled pilot trial comparing the experimental treatment to usual services in the community.

Conditions

Substance-Related Disorders; Depressive Disorder; Anxiety Disorder

Keywords

Substance-Related Disorders; Depressive Disorder; Anxiety Disorder; Adolescent; Behavior Therapy; Cognitive Therapy; Outpatients; Family Relations; Systems Theory

Outcome Measures

Primary Outcomes (2)

• Urine Drug Screen at 4 weeks, 8 weeks, 12 weeks, 24 weeks

• Score on Depression/Anxiety Scale (RCADS) at 4 weeks, 8 weeks, 12 weeks, 24 weeks

Secondary Outcomes (8)

• Measured at Intake, 3 Months, and 6 Months

• Global assessment of symptoms

• Parenting

• School

• Behavioral

Interventions

Outpatient MST/OPTION-A BEHAVIORAL

Usual Services BEHAVIORAL

Eligibility Criteria

• Age: 12 Years - 17 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Presentation for outpatient treatment
• to 17 years of age
• Youth residing with at least one adult caregiver who serves as a parent figure
• Substance Abuse or Dependence Disorder
• Axis I Internalizing Disorder (Mood Disorder or Anxiety Disorder), based on the Diagnostic Interview Schedule for Children (DISC-IV; Shaffer, Fisher, Lucas, Dulcan, \& Schwab-Stone, 2000)

You may not qualify if:

• Pervasive Developmental Disorder
• Psychotic Disorder
• Severe or profound mental retardation (IQ of 45 or below)
• Families previously receiving Multisystemic Therapy

Sponsors & Collaborators

• Medical University of South Carolina: lead
• National Institute on Drug Abuse (NIDA): collaborator

Study Sites (1)

Medical University of South Carolina, Department of Psychiatry & Behavioral Sciences, Family Services Research Center

Charleston, South Carolina, 29425, United States

Location

MeSH Terms

Conditions

Substance-Related Disorders; Depressive Disorder; Anxiety Disorders

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders; Mental Disorders; Mood Disorders

Study Officials

• Ashli J Sheidow, PhD

  Medical University of South Carolina, Department of Psychiatry & Behavioral Sciences, Family Services Research Center

  PRINCIPAL INVESTIGATOR

• Scott W Henggeler, PhD

  Medical University of South Carolina, Department of Psychiatry & Behavioral Sciences, Family Services Research Center

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 21, 2007
• First Posted: February 22, 2007
• Study Start: October 1, 2004
• Primary Completion: August 1, 2007
• Study Completion: September 1, 2010
• Last Updated: June 14, 2018

Record last verified: 2010-07

Locations

US (1)